{"id":"cimicifuga-hiperico","safety":{"commonSideEffects":[{"rate":null,"effect":"Photosensitivity (from Hypericum)"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Drug-drug interactions (Hypericum is a CYP3A4 inducer)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cimicifuga contains triterpene glycosides and other phytochemicals that may act on serotonin receptors and estrogen pathways to reduce hot flashes and night sweats. Hypericum perforatum (St. John's Wort) is a known monoamine oxidase inhibitor and serotonin reuptake modulator that may improve mood and anxiety associated with menopause. The combination targets both vasomotor and psychological symptoms of the menopausal transition.","oneSentence":"This herbal combination product uses Cimicifuga (black cohosh) and Hypericum (St. John's Wort) to modulate serotonergic and hormonal pathways, potentially alleviating menopausal symptoms and mood disturbances.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:45:01.063Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal symptoms (hot flashes, night sweats, mood disturbances)"}]},"trialDetails":[{"nctId":"NCT01481025","phase":"PHASE3","title":"Efficacy and Safety for Cimicifuga/Hypericum Product","status":"UNKNOWN","sponsor":"Phytopharm Consulting Brazil","startDate":"2011-11","conditions":"Perimenopausal Disorder","enrollment":210}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Cimicifuga + Hiperico","genericName":"Cimicifuga + Hiperico","companyName":"Phytopharm Consulting Brazil","companyId":"phytopharm-consulting-brazil","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This herbal combination product uses Cimicifuga (black cohosh) and Hypericum (St. John's Wort) to modulate serotonergic and hormonal pathways, potentially alleviating menopausal symptoms and mood disturbances. Used for Menopausal symptoms (hot flashes, night sweats, mood disturbances).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}