{"id":"cimicifuga-herbarium","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Rash"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cimicifuga contains triterpene glycosides and other phytochemicals that interact with estrogen receptors and serotonin pathways, reducing hot flashes and night sweats associated with menopause. The mechanism involves both direct estrogenic effects and modulation of thermoregulatory centers in the hypothalamus.","oneSentence":"Cimicifuga (black cohosh) herbarium extract modulates estrogen receptor signaling and reduces vasomotor symptoms through phytoestrogen activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:05:54.365Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Menopausal vasomotor symptoms (hot flashes, night sweats)"}]},"trialDetails":[{"nctId":"NCT01481025","phase":"PHASE3","title":"Efficacy and Safety for Cimicifuga/Hypericum Product","status":"UNKNOWN","sponsor":"Phytopharm Consulting Brazil","startDate":"2011-11","conditions":"Perimenopausal Disorder","enrollment":210}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Cimicifuga Herbarium","genericName":"Cimicifuga Herbarium","companyName":"Phytopharm Consulting Brazil","companyId":"phytopharm-consulting-brazil","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cimicifuga (black cohosh) herbarium extract modulates estrogen receptor signaling and reduces vasomotor symptoms through phytoestrogen activity. Used for Menopausal vasomotor symptoms (hot flashes, night sweats).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}