{"id":"cimetropium","rwe":[{"pmid":"41866875","year":"2025","title":"Expert Opinion on the Efficacy and Safety of Antispasmodics with a Focus on Irritable Bowel Syndrome.","finding":"","journal":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","studyType":"Clinical Study"},{"pmid":"36277191","year":"2022","title":"Acupuncture vs. antispasmodics in the treatment of irritable bowel syndrome: An adjusted indirect treatment comparison meta-analysis.","finding":"","journal":"Frontiers in physiology","studyType":"Clinical Study"},{"pmid":"35319761","year":"2022","title":"Assessment of Cimetropium Bromide Use for the Detection of Gastric Neoplasms During Esophagogastroduodenoscopy.","finding":"","journal":"JAMA network open","studyType":"Clinical Study"},{"pmid":"35281934","year":"2022","title":"Eluxadoline Versus Antispasmodics in the Treatment of Irritable Bowel Syndrome: An Adjusted Indirect Treatment Comparison Meta-analysis.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"},{"pmid":"33725813","year":"2021","title":"Xiaoyao-san, a traditional Chinese herbal formula, for the treatment of irritable bowel syndrome: A protocol for a systematic review and meta-analysis.","finding":"","journal":"Medicine","studyType":"Clinical Study"}],"tags":[{"label":"cimetropium","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A03BB05","category":"atc"},{"label":"Active","category":"status"},{"label":"Parasympatholytics","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cyclopropylmethylscopolamine bromide","offLabel":[],"synonyms":["cimetropium bromide","cyclopropylmethylscopolamine bromide","cimetropium"],"timeline":[],"approvals":[],"brandName":"Cyclopropylmethylscopolamine Bromide","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"cimetropium","explanation":"Imagine your body's nervous system as a complex network of messengers. CIMETROPIUM helps to slow down or block some of these messengers, which can help to reduce symptoms in certain conditions. This can lead to a range of effects, including relaxation of smooth muscle and decreased secretions.","oneSentence":"CIMETROPIUM works by blocking muscarinic receptors in the body, which are involved in various physiological processes.","technicalDetail":"CIMETROPIUM acts as a competitive antagonist at muscarinic acetylcholine receptors, specifically M1-M5 subtypes, which are involved in various physiological processes including smooth muscle contraction, glandular secretion, and neurotransmission."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/646","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CIMETROPIUM","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CIMETROPIUM","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T10:02:44.105181","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:42:45.403175+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"methscopolamine","drugSlug":"methscopolamine","fdaApproval":"1953-04-09","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methylhomatropine","drugSlug":"methylhomatropine","fdaApproval":"1943-03-23","relationship":"same-class"}],"genericName":"cimetropium","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"methscopolamine","brandName":"methscopolamine","genericName":"methscopolamine","approvalYear":"1953","relationship":"same-class"},{"drugId":"methylhomatropine","brandName":"methylhomatropine","genericName":"methylhomatropine","approvalYear":"1943","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT01842932","phase":"PHASE4","title":"Usefulness Of Flospan As A Premedication For Colonoscopy","status":"UNKNOWN","sponsor":"Ajou University School of Medicine","startDate":"2009-12","conditions":["Colonoscopy"],"enrollment":260,"completionDate":"2015-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"010897","UNII":"1N3H74AYTK","CHEBI":"CHEBI:135516","INN_ID":"5478","UMLSCUI":"C0141757","ChEMBL_ID":"CHEMBL2110773","KEGG_DRUG":"D07099","DRUGBANK_ID":"DB09271","PUBCHEM_CID":"20054871","SECONDARY_CAS_RN":"150521-16-7","MESH_SUPPLEMENTAL_RECORD_UI":"C016859"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"0.83 hours","clearance":"25.0 mL/min/kg","bioavailability":"2%","volumeOfDistribution":"1.12 L/kg"},"publicationCount":57,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"A03BB05","allCodes":["A03BB05"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Nov 25","pmid":"41866875","title":"Expert Opinion on the Efficacy and Safety of Antispasmodics with a Focus on Irritable Bowel Syndrome.","journal":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology"},{"date":"2022","pmid":"36277191","title":"Acupuncture vs. antispasmodics in the treatment of irritable bowel syndrome: An adjusted indirect treatment comparison meta-analysis.","journal":"Frontiers in physiology"},{"date":"2022 Mar 1","pmid":"35319761","title":"Assessment of Cimetropium Bromide Use for the Detection of Gastric Neoplasms During Esophagogastroduodenoscopy.","journal":"JAMA network open"},{"date":"2022","pmid":"35281934","title":"Eluxadoline Versus Antispasmodics in the Treatment of Irritable Bowel Syndrome: An Adjusted Indirect Treatment Comparison Meta-analysis.","journal":"Frontiers in pharmacology"},{"date":"2021 Mar 12","pmid":"33725813","title":"Xiaoyao-san, a traditional Chinese herbal formula, for the treatment of irritable bowel syndrome: A protocol for a systematic review and meta-analysis.","journal":"Medicine"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cyclopropylmethylscopolamine Bromide is a small molecule with synonyms CIMETROPIUM CATION and CIMETROPIUM ION.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:42:45.403175+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}