{"id":"cicloprolol","rwe":[{"pmid":"28917751","year":"2018","title":"Structural characterization of electrochemically and in vivo generated potential metabolites of selected cardiovascular drugs by EC-UHPLC/ESI-MS using an experimental design approach.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"1360256","year":"1992","title":"Combined invasive and noninvasive study of left ventricular systolic and diastolic function following acute administration of cicloprolol to subjects with normal cardiac function.","finding":"","journal":"Cardiovascular drugs and therapy","studyType":"Clinical Study"},{"pmid":"1347258","year":"1992","title":"An evaluation of the safety of the beta-modulator cicloprolol in chronic heart failure.","finding":"","journal":"Clinical cardiology","studyType":"Clinical Study"},{"pmid":"1681848","year":"1991","title":"Pharmacokinetics and safety of cicloprolol in uraemic patients.","finding":"","journal":"British journal of clinical pharmacology","studyType":"Clinical Study"},{"pmid":"1977438","year":"1990","title":"Pharmacodynamic without pharmacokinetic interaction between cicloprolol, a partial beta 1-adrenoceptor agonist, and digoxin in healthy subjects.","finding":"","journal":"British journal of clinical pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"cicloprolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Beta-1 adrenergic receptor","category":"target"},{"label":"ADRB1","category":"gene"},{"label":"ADRB2","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cycloprolol","offLabel":[],"synonyms":["cicloprolol","cicloprolol hydrochloride","cycloprolol","cicloprolol HCl"],"timeline":[],"approvals":[],"brandName":"Cycloprolol","ecosystem":[],"mechanism":{"target":"Beta-1 adrenergic receptor, Beta-2 adrenergic receptor","targets":[{"gene":"ADRB1","source":"DrugCentral","target":"Beta-1 adrenergic receptor","protein":"Beta-1 adrenergic receptor"},{"gene":"ADRB2","source":"DrugCentral","target":"Beta-2 adrenergic receptor","protein":"Beta-2 adrenergic receptor"}],"modality":"Small Molecule","drugClass":"cicloprolol","explanation":"Imagine your heart is like a racing car engine. The beta-1 adrenergic receptor is like the accelerator pedal. When it's stimulated, the engine revs up and the heart beats faster. Cycloprolol is like a brake that slows down the engine, reducing the heart's workload and slowing down the heart rate.","oneSentence":"Cycloprolol works by blocking the beta-1 adrenergic receptor, which reduces the heart's workload and slows heart rate.","technicalDetail":"Cycloprolol acts as a selective beta-1 adrenergic receptor antagonist, competing with endogenous catecholamines (such as epinephrine and norepinephrine) for binding sites on the receptor, thereby reducing the heart rate and contractility."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/637","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CICLOPROLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:59:56.548405","biosimilars":[],"competitors":[{"drugName":"acebutolol","drugSlug":"acebutolol","fdaApproval":"1984-12-28","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"amiodarone","drugSlug":"amiodarone","fdaApproval":"1985-12-24","patentExpiry":"Mar 13, 2029","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"arbutamine","drugSlug":"arbutamine","fdaApproval":"1997-09-12","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"arformoterol","drugSlug":"arformoterol","fdaApproval":"2006-10-06","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"aripiprazole","drugSlug":"aripiprazole","fdaApproval":"2002-11-15","patentExpiry":"Sep 24, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"asenapine","drugSlug":"asenapine","fdaApproval":"2009-08-13","patentExpiry":"Sep 22, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-target"},{"drugName":"atenolol","drugSlug":"atenolol","fdaApproval":"1981-08-19","genericCount":22,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"betaxolol","drugSlug":"betaxolol","fdaApproval":"1985-08-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"bisoprolol","drugSlug":"bisoprolol","fdaApproval":"1992-07-31","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"cicloprolol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"acebutolol","brandName":"acebutolol","genericName":"acebutolol","approvalYear":"1984","relationship":"same-target"},{"drugId":"amiodarone","brandName":"amiodarone","genericName":"amiodarone","approvalYear":"1985","relationship":"same-target"},{"drugId":"arbutamine","brandName":"arbutamine","genericName":"arbutamine","approvalYear":"1997","relationship":"same-target"},{"drugId":"arformoterol","brandName":"arformoterol","genericName":"arformoterol","approvalYear":"2006","relationship":"same-target"},{"drugId":"aripiprazole","brandName":"aripiprazole","genericName":"aripiprazole","approvalYear":"2002","relationship":"same-target"},{"drugId":"asenapine","brandName":"asenapine","genericName":"asenapine","approvalYear":"2009","relationship":"same-target"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-target"},{"drugId":"atenolol","brandName":"atenolol","genericName":"atenolol","approvalYear":"1981","relationship":"same-target"},{"drugId":"betaxolol","brandName":"betaxolol","genericName":"betaxolol","approvalYear":"1985","relationship":"same-target"},{"drugId":"bisoprolol","brandName":"bisoprolol","genericName":"bisoprolol","approvalYear":"1992","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"1K2ACH4U3R","CHEBI":"CHEBI:135377","INN_ID":"5250","UMLSCUI":"C0055713","ChEMBL_ID":"CHEMBL255015","KEGG_DRUG":"D03490","PUBCHEM_CID":"146294","IUPHAR_LIGAND_ID":"552","SECONDARY_CAS_RN":"63686-79-3","MESH_SUPPLEMENTAL_RECORD_UI":"C053708"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"99%"},"publicationCount":15,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"2018 Jan 1","pmid":"28917751","title":"Structural characterization of electrochemically and in vivo generated potential metabolites of selected cardiovascular drugs by EC-UHPLC/ESI-MS using an experimental design approach.","journal":"Talanta"},{"date":"1992 Oct","pmid":"1360256","title":"Combined invasive and noninvasive study of left ventricular systolic and diastolic function following acute administration of cicloprolol to subjects with normal cardiac function.","journal":"Cardiovascular drugs and therapy"},{"date":"1992 Jan","pmid":"1347258","title":"An evaluation of the safety of the beta-modulator cicloprolol in chronic heart failure.","journal":"Clinical cardiology"},{"date":"1991 Aug","pmid":"1681848","title":"Pharmacokinetics and safety of cicloprolol in uraemic patients.","journal":"British journal of clinical pharmacology"},{"date":"1990 Sep","pmid":"1977438","title":"Pharmacodynamic without pharmacokinetic interaction between cicloprolol, a partial beta 1-adrenoceptor agonist, and digoxin in healthy subjects.","journal":"British journal of clinical pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cycloprolol, also known as CICLOPROLOL, is a small molecule drug that targets the beta-1 adrenergic receptor. It is classified as a cicloprolol, a type of beta-blocker. However, due to the lack of available information, its commercial status, approved indications, and pharmacokinetic properties are unknown. As a result, it is not possible to provide a comprehensive summary of its use and safety considerations. Further research is needed to determine its clinical utility and potential risks.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}