{"id":"ciclopirox-nl","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ciclopirox works by forming a complex with iron and other metal ions essential for fungal cytochrome P450 enzyme function. This disrupts multiple metabolic pathways including energy production, nucleic acid synthesis, and cell wall integrity, making it effective against a wide range of fungi and some bacteria. The mechanism allows it to be used topically for superficial fungal infections with minimal systemic absorption.","oneSentence":"Ciclopirox is a broad-spectrum antifungal agent that inhibits fungal enzyme systems by chelating polyvalent cations, disrupting cellular respiration and biosynthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:08.930Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Onychomycosis (fungal nail infection)"},{"name":"Tinea pedis (athlete's foot)"},{"name":"Tinea corporis (ringworm)"},{"name":"Tinea cruris (jock itch)"},{"name":"Candidiasis (yeast infections)"},{"name":"Pityriasis versicolor"}]},"trialDetails":[{"nctId":"NCT02679911","phase":"PHASE4","title":"Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2015-09","conditions":"Foot Dermatoses","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ciclopirox Nail Lacquer"],"phase":"marketed","status":"active","brandName":"Ciclopirox NL","genericName":"Ciclopirox NL","companyName":"Galderma R&D","companyId":"galderma-r-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ciclopirox is a broad-spectrum antifungal agent that inhibits fungal enzyme systems by chelating polyvalent cations, disrupting cellular respiration and biosynthesis. Used for Onychomycosis (fungal nail infection), Tinea pedis (athlete's foot), Tinea corporis (ringworm).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}