{"id":"ciclopirox-8","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":{"setId":"87480bb9-e7a7-5ef1-e053-2995a90a0e40","title":"CICLOPIROX 8% / FLUCONAZOLE 1% / TERBINAFINE HCL 1% SOLUTION [SINCERUS FLORIDA, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ciclopirox works by forming a complex with trivalent cations (iron and aluminum) that are essential cofactors for fungal cytochrome P450 enzymes and other metalloenzymes. This inhibition disrupts multiple metabolic pathways including energy production, nucleic acid synthesis, and cell wall integrity. The 8% formulation is typically used as a topical treatment for fungal infections of the skin and nails.","oneSentence":"Ciclopirox is a broad-spectrum antifungal agent that inhibits fungal enzyme systems by chelating polyvalent cations, disrupting cellular respiration and biosynthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:05:52.094Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Onychomycosis (fungal nail infection)"},{"name":"Tinea pedis, tinea corporis, and other dermatophyte infections"},{"name":"Candida and other fungal skin infections"}]},"trialDetails":[{"nctId":"NCT06485050","phase":"NA","title":"Photodynamic Therapy and Topical Antifungal for Onychomycosis in Patients With Diabetes.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Universidad Complutense de Madrid","startDate":"2024-04-17","conditions":"Dermatologic Disease, Onychomycosis of Toenail, Diabetic Foot","enrollment":10},{"nctId":"NCT05809297","phase":"PHASE4","title":"Diode Laser and Photodynamic Therapy Vs. Ciclopirox.","status":"UNKNOWN","sponsor":"Universidad Complutense de Madrid","startDate":"2023-09-01","conditions":"Onychomycosis","enrollment":26},{"nctId":"NCT02679911","phase":"PHASE4","title":"Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2015-09","conditions":"Foot Dermatoses","enrollment":20},{"nctId":"NCT02961634","phase":"PHASE3","title":"Study Efficacy and Safety in Comparative Use of Investigational Product Adjuvant Treatment in Onychomycosis","status":"UNKNOWN","sponsor":"MIP Brasil Indústria e Comércio de Produtos Farmacêuticos LTDA","startDate":"2017-04","conditions":"Onychomycosis","enrollment":46},{"nctId":"NCT01014637","phase":"PHASE4","title":"Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis","status":"UNKNOWN","sponsor":"Pierre Fabre Dermo Cosmetique","startDate":"2009-08","conditions":"Onychomycosis","enrollment":260}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":38,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ciclopirox 8%","genericName":"Ciclopirox 8%","companyName":"MIP Brasil Indústria e Comércio de Produtos Farmacêuticos LTDA","companyId":"mip-brasil-ind-stria-e-com-rcio-de-produtos-farmac-uticos-ltda","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ciclopirox is a broad-spectrum antifungal agent that inhibits fungal enzyme systems by chelating polyvalent cations, disrupting cellular respiration and biosynthesis. Used for Onychomycosis (fungal nail infection), Tinea pedis, tinea corporis, and other dermatophyte infections, Candida and other fungal skin infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}