{"id":"ciclesonide-xrp1526","safety":{"commonSideEffects":[{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"},{"rate":null,"effect":"Nervousness"},{"rate":null,"effect":"Throat irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ciclesonide is a prodrug that is converted to its active metabolite in the lungs, where it binds to glucocorticoid receptors and suppresses inflammatory gene expression. This reduces the production of inflammatory mediators and recruitment of immune cells to the airways, thereby decreasing airway inflammation and improving airflow obstruction in respiratory diseases.","oneSentence":"Ciclesonide is an inhaled corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors in lung tissue.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:05:51.167Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Asthma (maintenance therapy)"},{"name":"Chronic obstructive pulmonary disease (COPD)"}]},"trialDetails":[{"nctId":"NCT00254956","phase":"PHASE3","title":"Effects Of Ciclesonide And Beclomethasone On Lens Opacification In Adult Subjects With Moderate To Severe Persistent Asthma","status":"COMPLETED","sponsor":"Sanofi","startDate":"2004-01","conditions":"Respiratory Tract Diseases, Respiratory Hypersensitivity, Asthma","enrollment":1568},{"nctId":"NCT00174720","phase":"PHASE3","title":"Efficacy of Ciclesonide vs Placebo Administered as Once Daily or Twice Daily in Patients Not Treated With Inhaled Corticosteroid.","status":"COMPLETED","sponsor":"Sanofi","startDate":"2005-09","conditions":"Asthma","enrollment":708},{"nctId":"NCT00174733","phase":"PHASE3","title":"Efficacy of Ciclesonide Versus Placebo Administered Either as Once Daily or Twice Daily in Patients Treated Previously With an Inhaled Corticosteroid","status":"COMPLETED","sponsor":"Sanofi","startDate":"2005-07","conditions":"Asthma","enrollment":456}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Ciclesonide (XRP1526)","genericName":"Ciclesonide (XRP1526)","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ciclesonide is an inhaled corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors in lung tissue. Used for Asthma (maintenance therapy), Chronic obstructive pulmonary disease (COPD).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}