{"id":"ciclesonide-nasal-spray-placebo-azelastine","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Epistaxis (nosebleed)"},{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Pharyngitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ciclesonide is a prodrug that is converted to its active metabolite in the nasal mucosa, where it binds to glucocorticoid receptors and suppresses inflammatory cytokine production, reducing nasal congestion, rhinorrhea, and sneezing associated with allergic rhinitis. This formulation combines ciclesonide nasal spray with placebo azelastine (a histamine H1-receptor antagonist), allowing evaluation of ciclesonide monotherapy efficacy.","oneSentence":"Ciclesonide is an intranasal corticosteroid that reduces airway inflammation and mucus production to relieve nasal allergy symptoms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:08.941Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis (seasonal and perennial)"}]},"trialDetails":[{"nctId":"NCT00806754","phase":"PHASE4","title":"Investigation of the Efficacy and Safety of Concomitant Administration of Ciclesonide Nasal Spray and Azelastine Nasal Spray in Patients (18 Years or Older) With Perennial Allergic Rhinitis (PAR) Not Adequately Controlled on an Intranasal Corticosteroid or Antihistamine Monotherapy (BY9010/M1-490)","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2006-11","conditions":"Rhinitis, Allergic, Perennial","enrollment":340}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ciclesonide nasal spray + placebo Azelastine","genericName":"Ciclesonide nasal spray + placebo Azelastine","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ciclesonide is an intranasal corticosteroid that reduces airway inflammation and mucus production to relieve nasal allergy symptoms. Used for Allergic rhinitis (seasonal and perennial).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}