{"id":"ciclesonide-levocetirizine","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Pharyngitis"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Somnolence"},{"rate":null,"effect":"Dysphonia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ciclesonide works by binding to glucocorticoid receptors in the lungs, suppressing inflammatory cytokine production and reducing airway edema and mucus secretion. Levocetirizine competitively blocks H1 histamine receptors on mast cells and other immune cells, preventing histamine-induced allergic symptoms such as itching, sneezing, and rhinitis. Together, they provide dual anti-inflammatory and antihistamine effects for allergic airway disease.","oneSentence":"Ciclesonide is an inhaled corticosteroid that reduces airway inflammation, while levocetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:30:08.936Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis with asthma or allergic airway disease"}]},"trialDetails":[{"nctId":"NCT01430260","phase":"PHASE4","title":"Omnaris Versus Levocetirizine Phase 4 Study","status":"COMPLETED","sponsor":"Handok Inc.","startDate":"2011-01","conditions":"Allergic Rhinitis","enrollment":349}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Omnaris nasal spray","XYZAL"],"phase":"marketed","status":"active","brandName":"Ciclesonide & Levocetirizine","genericName":"Ciclesonide & Levocetirizine","companyName":"Handok Inc.","companyId":"handok-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ciclesonide is a glucocorticoid receptor agonist, classified as a small molecule, and is used to treat Allergic Rhinitis. When combined with Levocetirizine, a medication used to treat Allergic Rhinitis, Ciclesonide may be used to treat the condition as well.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}