{"id":"ci-581a","safety":{"commonSideEffects":[{"rate":null,"effect":"Dissociative/psychotomimetic effects"},{"rate":null,"effect":"Emergence reactions"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Nausea/vomiting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"CI-581a (ketamine) blocks N-methyl-D-aspartate (NMDA) glutamate receptors, leading to dissociative anesthesia characterized by analgesia, amnesia, and unconsciousness while preserving airway reflexes and respiratory drive. The drug produces its effects through non-competitive antagonism at the phencyclidine binding site within the NMDA receptor ion channel.","oneSentence":"CI-581a is a dissociative anesthetic that acts as an NMDA receptor antagonist to produce rapid-onset anesthesia and analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:05:49.227Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of anesthesia"},{"name":"Analgesia and sedation"}]},"trialDetails":[{"nctId":"NCT05690503","phase":"PHASE2","title":"Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"New York State Psychiatric Institute","startDate":"2023-03-20","conditions":"Post-acute Sequelae of COVID-19, Depressive Symptoms, Cognitive Dysfunction","enrollment":12},{"nctId":"NCT03344419","phase":"PHASE3","title":"Glutamatergic Modulation to Facilitate the Behavioral Treatment of Cocaine Use Disorders","status":"SUSPENDED","sponsor":"New York State Psychiatric Institute","startDate":"2017-10-01","conditions":"Cocaine Use Disorder","enrollment":150},{"nctId":"NCT03345173","phase":"PHASE3","title":"Facilitating Rapid Naltrexone Initiation","status":"ACTIVE_NOT_RECRUITING","sponsor":"New York State Psychiatric Institute","startDate":"2017-11-25","conditions":"Opioid Dependence","enrollment":100},{"nctId":"NCT04084860","phase":"PHASE2","title":"The Role of Brief Potent Glutamatergic Modulation in Addressing Problem Drinking","status":"UNKNOWN","sponsor":"New York State Psychiatric Institute","startDate":"2019-11-08","conditions":"Alcohol Use Disorder","enrollment":120},{"nctId":"NCT02946489","phase":"PHASE1","title":"Facilitating the Behavioral Treatment of Cannabis Use Disorder","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2016-10","conditions":"Cannabis Dependence","enrollment":8},{"nctId":"NCT02539511","phase":"PHASE2, PHASE3","title":"Glutamatergic Modulation of Disordered Alcohol Use","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2015-07","conditions":"Alcohol Dependence","enrollment":50},{"nctId":"NCT02596022","phase":"PHASE2","title":"The Effect of Glutamatergic Modulation on Cocaine Self-administration","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2013-06","conditions":"Cocaine Dependence","enrollment":18}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"CI-581a","genericName":"CI-581a","companyName":"New York State Psychiatric Institute","companyId":"new-york-state-psychiatric-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CI-581a is a dissociative anesthetic that acts as an NMDA receptor antagonist to produce rapid-onset anesthesia and analgesia. Used for Induction and maintenance of anesthesia, Analgesia and sedation.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}