{"id":"chondroitin-sulfate","rwe":[{"pmid":"41902922","year":"2026","title":"Impact of Intravesical Chondroitin Sulfate Instillation on Sexual Function in Women with Interstitial Cystitis/Bladder Pain Syndrome.","finding":"","journal":"International urogynecology journal","studyType":"Clinical Study"},{"pmid":"41901230","year":"2026","title":"Influence of Propolis-Containing Nonwoven PLGA Dressings on Dermatan and Chondroitin Sulfate Dynamics During Burn-Wound Healing.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41895487","year":"2026","title":"Delivery growth factors by layer-by-layer assembly in nanofibers for enhancing bone defect repairment along with neurogenesis.","finding":"","journal":"International journal of biological macromolecules","studyType":"Clinical Study"},{"pmid":"41894675","year":"2026","title":"Profiling of the Golgi Apparatus Proteome in Living Cells Using Nanophotosensitizer-Mediated Photocatalytic Proximity Labeling.","finding":"","journal":"Analytical chemistry","studyType":"Clinical Study"},{"pmid":"41892974","year":"2026","title":"Identification of an Unpredicted GAG-PUL in Roseihalotalea indica gen. nov. sp. nov. TK19036(T) and Characterization of Novel GAG-Lyases with Unique Substrate Specificities.","finding":"","journal":"Marine drugs","studyType":"Clinical Study"}],"tags":[{"label":"chondroitin sulfate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M01AX25","category":"atc"},{"label":"Active","category":"status"},{"label":"Operation on lens","category":"indication"},{"label":"Surgical procedure on eye proper","category":"indication"}],"phase":"discontinued","safety":{"contraindications":["Arteriosclerosis obliterans","Diabetes mellitus","Glaucoma","Hypercalcemia","Hyperlipidemia","Hyperphosphatemia","Hypertensive disorder","Hypervitaminosis D","Kidney disease","Kidney stone","Sarcoidosis"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"chondroitin sulphate","offLabel":[],"synonyms":["chondroitin sulfate","chondroitin polysulfate","chondroitin sulphate","chondroitinsulfuric acid"],"timeline":[],"approvals":[],"brandName":"Chondroitin Sulphate","ecosystem":[{"indication":"Operation on lens","otherDrugs":[{"name":"hyaluronic acid","slug":"hyaluronic-acid","company":""}],"globalPrevalence":null},{"indication":"Surgical procedure on eye proper","otherDrugs":[{"name":"hyaluronic acid","slug":"hyaluronic-acid","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"chondroitin sulfate","explanation":"Imagine your body's tissues are like a complex web of fibers. Chondroitin Sulphate helps surgeons navigate and repair this web by interacting with the fibers, making it easier to perform delicate eye surgeries.","oneSentence":"Chondroitin Sulphate works by interacting with proteoglycans in the eye to facilitate surgical procedures.","technicalDetail":"Chondroitin Sulphate is a sulfated glycosaminoglycan that binds to proteoglycans in the extracellular matrix, modulating the viscoelastic properties of the tissue and facilitating surgical procedures."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4103","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CHONDROITIN%20SULFATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHONDROITIN SULFATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:36:17.935215","biosimilars":[],"competitors":[{"drugName":"nabumetone","drugSlug":"nabumetone","fdaApproval":"1991-12-24","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"glucosamine","drugSlug":"glucosamine","fdaApproval":"","relationship":"same-class"},{"drugName":"orgotein","drugSlug":"orgotein","fdaApproval":"","relationship":"same-class"}],"genericName":"chondroitin sulfate","indications":{"approved":[{"name":"Operation on lens","source":"DrugCentral","snomedId":386612009,"regulator":"FDA"},{"name":"Surgical procedure on eye proper","source":"DrugCentral","snomedId":373353005,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nabumetone","brandName":"nabumetone","genericName":"nabumetone","approvalYear":"1991","relationship":"same-class"},{"drugId":"glucosamine","brandName":"glucosamine","genericName":"glucosamine","approvalYear":"","relationship":"same-class"},{"drugId":"orgotein","brandName":"orgotein","genericName":"orgotein","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07495072","phase":"NA","title":"Early vs Delayed Intravesical Blad-Care During BCG Therapy","status":"RECRUITING","sponsor":"BLAD-HYA Group","startDate":"2025-11-03","conditions":["Urinary Bladder Neoplasms","BCG-Induced Cystitis"],"enrollment":56,"completionDate":"2027-06"},{"nctId":"NCT07493239","phase":"NA","title":"A Decentralized Clinical Study Evaluating the Effectiveness of Two Different Doses of MyCondro™ on Physical Mobility and Joint Health","status":"RECRUITING","sponsor":"Lesaffre International","startDate":"2026-03","conditions":["Joint Health"],"enrollment":240,"completionDate":"2026-11-02"},{"nctId":"NCT07476508","phase":"NA","title":"\"Intra-articular Hyaluronic Acid Injection for Accelerating Functional Recovery After Knee Arthroscopy\"","status":"COMPLETED","sponsor":"Collegium Medicum w Bydgoszczy","startDate":"2019-10-10","conditions":["Meniscus Lesion","Knee Injuries","Medial Meniscus Tear"],"enrollment":290,"completionDate":"2022-03-31"},{"nctId":"NCT07290673","phase":"NA","title":"Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers","status":"NOT_YET_RECRUITING","sponsor":"Samaritan Biologics","startDate":"2026-04-01","conditions":["Diabetic Foot Ulcer (DFU)"],"enrollment":124,"completionDate":"2027-12-31"},{"nctId":"NCT04702776","phase":"PHASE4","title":"Study to Compare the Efficacy of the Ophthalmic Solution Humylub Ofteno® PF With Hyabak® and Lagricel Ofteno® PF as Treatment for Dry Eye.","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2021-12-09","conditions":["Dry Eye"],"enrollment":182,"completionDate":"2023-05-15"},{"nctId":"NCT06096038","phase":"PHASE1,PHASE2","title":"Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC","status":"RECRUITING","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2024-04-05","conditions":["Head and Neck Cancer","Relapse","Recurrent","Refractory Cancer"],"enrollment":33,"completionDate":"2028-08-01"},{"nctId":"NCT06917287","phase":"NA","title":"A Clinical Study to Evaluate the Efficacy of Native CT-II® in Individuals With Knee Osteoarthritis","status":"RECRUITING","sponsor":"Vedic Lifesciences Pvt. Ltd.","startDate":"2025-04-20","conditions":["Knee Osteoarthritis (OA)"],"enrollment":114,"completionDate":"2026-02-15"},{"nctId":"NCT07237984","phase":"","title":"Colorectal Omics and ofCS Proteoglycans (COCO) in Screening and a Diagnostic Pathway","status":"NOT_YET_RECRUITING","sponsor":"Nordsjaellands Hospital","startDate":"2026-03-01","conditions":["Colorectal Cancer","Colorectal Adenoma","Inflammatory Bowel Disease (IBD)"],"enrollment":2000,"completionDate":"2031-12-31"},{"nctId":"NCT03697876","phase":"PHASE1","title":"Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2018-08-20","conditions":["Dry Eye Syndromes"],"enrollment":32,"completionDate":"2024-06-26"},{"nctId":"NCT07323745","phase":"EARLY_PHASE1","title":"Long-Term Effects of Mobithron Advance on Knee Osteoarthritis Aims to Investigate the Effects of Mobithron Advance on OA Progression","status":"NOT_YET_RECRUITING","sponsor":"Universiti Sains Malaysia","startDate":"2025-12-30","conditions":["Osteoarthritis (OA) of the Knee"],"enrollment":84,"completionDate":"2027-10-31"},{"nctId":"NCT06547424","phase":"PHASE1","title":"Phase I Clinical Study of Chondroitin Sulfate for Treatment of NEC","status":"WITHDRAWN","sponsor":"Indiana University","startDate":"2025-01","conditions":["Necrotizing Enterocolitis","Intestinal Ischemia"],"enrollment":0,"completionDate":"2029-03"},{"nctId":"NCT07119645","phase":"NA","title":"NT-II™ Collagen for Joint Discomfort and Function","status":"NOT_YET_RECRUITING","sponsor":"Hofseth Biocare ASA","startDate":"2025-10-19","conditions":["Activity-Related Knee Discomfort","Joint Discomfort","Functional Joint Pain","Functional Knee Pain","Knee Acute and Chronic Pain"],"enrollment":120,"completionDate":"2026-03-15"},{"nctId":"NCT05687019","phase":"NA","title":"Efficacy of Hyaluronic Acid Injections on Functional Recovery After Surgery for Prostate Adenoma","status":"COMPLETED","sponsor":"GCS Ramsay Santé pour l'Enseignement et la Recherche","startDate":"2023-09-12","conditions":["Prostatic Adenoma"],"enrollment":33,"completionDate":"2025-06-24"},{"nctId":"NCT06623773","phase":"","title":"Study on Structum® in Adult Patients With Osteoarthritis (TRUST)","status":"COMPLETED","sponsor":"Pierre Fabre Medicament","startDate":"2023-06-27","conditions":["Osteoarthritis, Knee"],"enrollment":151,"completionDate":"2024-10-28"},{"nctId":"NCT06032442","phase":"NA","title":"A Study to Assess Efficacy of Supporting Properties and Safety of ARTNEO in Patients With Knee Osteoarthritis","status":"COMPLETED","sponsor":"NPO Petrovax","startDate":"2022-03-21","conditions":["Osteoarthritis","Osteo Arthritis Knee","Osteoarthritis, Knee"],"enrollment":70,"completionDate":"2023-07-18"},{"nctId":"NCT05995626","phase":"EARLY_PHASE1","title":"Hyaluronidase Via LADD Scleroderma-induced Microstomia","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2024-03-01","conditions":["Microstomia","Scleroderma"],"enrollment":3,"completionDate":"2024-09-24"},{"nctId":"NCT06890247","phase":"","title":"Single-Dose Hybrid Hyaluronic Acid and Sodium Chondroitin with Rehabilitation for Sports Adults with Knee Osteoarthritis","status":"NOT_YET_RECRUITING","sponsor":"University of Palermo","startDate":"2025-05","conditions":["Osteoarthritis, Knee"],"enrollment":100,"completionDate":"2026-01"},{"nctId":"NCT04095572","phase":"PHASE4","title":"Alternative Prophylaxis in Female Recurrent Urinary Tract Infections","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2020-10-27","conditions":["Urinary Tract Infections","Urinary Tract Infection (UTI)"],"enrollment":50,"completionDate":"2026-06"},{"nctId":"NCT06798428","phase":"NA","title":"For Grade I and II Knee Meniscal Injuries Patients ,Glucosamine, Chondroitin and Some Herbs Extract Phonophoresis Will Be Used (A) Versus Placebo(B)","status":"COMPLETED","sponsor":"Eslam Elsayed Ali Shohda","startDate":"2022-10-01","conditions":["Grade I and II Knee Meniscal Injuries"],"enrollment":45,"completionDate":"2024-03-01"},{"nctId":"NCT06287671","phase":"","title":"Colorectal Omics and OfCS Proteoglycans","status":"RECRUITING","sponsor":"Claus Anders Bertelsen, PhD, MD","startDate":"2024-10-08","conditions":["Colorectal Cancer","Diverticulitis, Colonic","Inflammatory Bowel Diseases","Stoma Colostomy"],"enrollment":1000,"completionDate":"2032-12-31"},{"nctId":"NCT06659016","phase":"PHASE4","title":"Efficacy of Collagen, Propolis Plus Quercetin (Proqutin®), Bacillus Coagulans, Hyaluronic Acid and Chondroitin Sulphate and D-Mannose to Avoid Symptoms and Prevents Recurrence in Women With Recurrent Urinary Tract Infections","status":"COMPLETED","sponsor":"University of Campania Luigi Vanvitelli","startDate":"2023-02-01","conditions":["Urinary Tract Infection (Diagnosis)"],"enrollment":148,"completionDate":"2024-09-30"},{"nctId":"NCT06573606","phase":"","title":"Ophthalmic Solution in Diabetic Corneal Alteration","status":"COMPLETED","sponsor":"D&V FARMA srl","startDate":"2021-09-01","conditions":["Dry Eye Disease (DED)"],"enrollment":20,"completionDate":"2022-09-01"},{"nctId":"NCT05613660","phase":"NA","title":"A Proof of Science, Dose-Response Study to Evaluate the Safety, Efficacy of Different Dosages of Test Treatments","status":"COMPLETED","sponsor":"NovoBliss Research Pvt Ltd","startDate":"2023-01-11","conditions":["Mild to Moderate Acne","Stiffness of Joint, Nec, Involving Ankle and Foot in MDR24_1","Other Specified Diseases of Hair and Hair Follicles","Brittle Nails","Osteoarthritis, Knee","Healthy"],"enrollment":264,"completionDate":"2023-06-30"},{"nctId":"NCT06101992","phase":"NA","title":"Mesoglycan for Acute Hemorrhoidal Disease","status":"UNKNOWN","sponsor":"Societa Italiana di Chirurgia ColoRettale","startDate":"2024-01-01","conditions":["Hemorrhoids"],"enrollment":50,"completionDate":"2024-09-01"},{"nctId":"NCT05632783","phase":"PHASE3","title":"TreatMent Of Knee osTeoarthritis wIth chONdroitin Sulfate - the OA MOTION Study","status":"WITHDRAWN","sponsor":"IBSA Institut Biochimique SA","startDate":"2023-12","conditions":["Knee Osteoarthritis"],"enrollment":0,"completionDate":"2026-07"},{"nctId":"NCT05474586","phase":"NA","title":"To Evaluate the Efficacy and Safety of Collavant n2 in Individuals With Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"Vedic Lifesciences Pvt. Ltd.","startDate":"2022-08-08","conditions":["Osteoarthritis, Knee"],"enrollment":236,"completionDate":"2023-07-04"},{"nctId":"NCT00150488","phase":"NA","title":"URACYST® For the Treatment of GAG Deficient Interstitial Cystitis","status":"COMPLETED","sponsor":"Dr. J. Curtis Nickel","startDate":"2005-09","conditions":["Painful Bladder Syndrome","Interstitial Cystitis"],"enrollment":53,"completionDate":"2008-02"},{"nctId":"NCT05926713","phase":"NA","title":"Evaluate the Effect of Dietary Supplement Combined Exercise Among Patients With Sarcopenia Comorbid With Lung Disease","status":"RECRUITING","sponsor":"Orient Europharma Co., Ltd.","startDate":"2023-03-01","conditions":["Sarcopenia","COPD","ILD"],"enrollment":100,"completionDate":"2032-10-31"},{"nctId":"NCT05400291","phase":"","title":"Gag-layer in the Urothelium of the Human Upper Urinary Tract","status":"COMPLETED","sponsor":"Aarhus University Hospital","startDate":"2021-12-01","conditions":["Bladder Cancer","Renal Cancer"],"enrollment":16,"completionDate":"2022-12-31"},{"nctId":"NCT04202692","phase":"NA","title":"Effect of a Combination Oral Formulation of Hyaluronic Acid, Chondroitin Sulphate and Magnesium Trisilicate in Patients With Gastro-Esophageal Reflux Disease Not Fully Satisfied With Their Treatment","status":"COMPLETED","sponsor":"SOFAR S.p.A.","startDate":"2019-11-05","conditions":["Gastro Esophageal Reflux"],"enrollment":40,"completionDate":"2022-11-23"},{"nctId":"NCT05799456","phase":"","title":"Glycosaminoglycan Scores as Early Detection Biomarkers in Bladder Urothelial Carcinoma","status":"COMPLETED","sponsor":"Jens Nielsen","startDate":"2018-10-01","conditions":["Bladder Cancer"],"enrollment":106,"completionDate":"2023-02-28"},{"nctId":"NCT05323370","phase":"","title":"Lymphangioleiomyomatosis, a Study on Cathepsin K","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2022-05-31","conditions":["Lymphangioleiomyomatosis","Tuberous Sclerosis Complex"],"enrollment":19,"completionDate":"2022-10-30"},{"nctId":"NCT03077087","phase":"NA","title":"Single-Stage Integra Reconstruction in Burns","status":"TERMINATED","sponsor":"HealthPartners Institute","startDate":"2017-04-10","conditions":["Thermal Burn"],"enrollment":2,"completionDate":"2019-07-24"},{"nctId":"NCT00955552","phase":"PHASE3","title":"Efficacy and Safety Study of Glucosamine/Chondroitin Sulfate to Patients Treatment With Osteoarthrosis of the Knee","status":"COMPLETED","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2010-08","conditions":["Osteoarthritis of the Knee"],"enrollment":100,"completionDate":"2011-06"},{"nctId":"NCT05322148","phase":"PHASE3","title":"Cyclosporine 0.1% / Loteprednol 0.2% Effect on Anterior Segment Normalization","status":"COMPLETED","sponsor":"Research Insight LLC","startDate":"2022-06-03","conditions":["Dry Eye"],"enrollment":59,"completionDate":"2022-11-21"},{"nctId":"NCT04661267","phase":"NA","title":"Randomized Trial of Regenexx Stem Cell Support Formula","status":"COMPLETED","sponsor":"Regenexx, LLC","startDate":"2021-02-03","conditions":["Knee Osteoarthritis"],"enrollment":80,"completionDate":"2022-10-31"},{"nctId":"NCT05212259","phase":"NA","title":"Clinical Study to Evaluate the Effect of Different Doses of UC-II® Supplementation on the Range of Motion & Joint Discomfort in Healthy Subjects","status":"UNKNOWN","sponsor":"Vedic Lifesciences Pvt. Ltd.","startDate":"2022-10-10","conditions":["Joint Pain"],"enrollment":375,"completionDate":"2023-09-15"},{"nctId":"NCT00691678","phase":"PHASE2","title":"Glucosamine and Chondroitin for Aromatase Inhibitor Induced Joint Symptoms in Women With Breast Cancer","status":"COMPLETED","sponsor":"Dawn L. Hershman","startDate":"2008-10","conditions":["Breast Cancer","Joint Pain"],"enrollment":53,"completionDate":"2012-09"},{"nctId":"NCT03463499","phase":"NA","title":"The Efficacy and Safety of Intravesical Hyaluronic Acid and Chondroitin Sulfate After Transurethral Resection of Hunner Lesion in Interstitial Cystitis/Bladder Pain Syndrome Patients","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2017-09-22","conditions":["Interstitial Cystitis"],"enrollment":62,"completionDate":"2021-12-31"},{"nctId":"NCT05489107","phase":"","title":"New Local Treatment of Radiation-induced Proctitis","status":"UNKNOWN","sponsor":"Barmherzige Brüder Vienna","startDate":"2022-07-01","conditions":["Radiation Proctitis"],"enrollment":50,"completionDate":"2023-07-31"},{"nctId":"NCT05464953","phase":"NA","title":"Suprachoroidal Triamcinolone Versus Posterior Subtenon Triamcinolone Alone or Formulated in the Management of Diabetic Macular Edema.","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2020-01-20","conditions":["Diabetic Macular Edema of Left Eye"],"enrollment":75,"completionDate":"2022-04-30"},{"nctId":"NCT05429229","phase":"PHASE2","title":"Effect of Topical Antioxidants in Dry Eye Disease and Diabetic Retinopathy","status":"UNKNOWN","sponsor":"Adolfo Daniel Rodriguez-Carrizalez","startDate":"2021-11-01","conditions":["Dry Eye Syndromes","Diabetic Retinopathy","Oxidative Stress","Tear Film Deficiency"],"enrollment":78,"completionDate":"2024-01-31"},{"nctId":"NCT05385562","phase":"NA","title":"Formulated PSTA Injection Versus PATA Alone in the Management of Macular Edema Secondary to Non-ischemic Retinal Vein Occlusions","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2020-01-02","conditions":["Macula Edema"],"enrollment":78,"completionDate":"2022-05-10"},{"nctId":"NCT03883074","phase":"NA","title":"Effect of a Combination of Hyaluronic Acid, Chondroitin Sulphate and Magnesium Trisilicate on Subjects With GastroEsophageal Reflux Disease","status":"COMPLETED","sponsor":"SOFAR S.p.A.","startDate":"2018-12-20","conditions":["Gastro Esophageal Reflux"],"enrollment":21,"completionDate":"2021-09-16"},{"nctId":"NCT05345808","phase":"NA","title":"Efficacy of Formulated Posterior Sub Tenon Triamcinolone in Macular Edema Secondary to Non-Ischemic Retinal Vein Occlusions","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2021-03-01","conditions":["Retinal Vein Occlusion"],"enrollment":46,"completionDate":"2022-03-30"},{"nctId":"NCT01657500","phase":"PHASE3","title":"Life 4°C Versus Optisol in Corneal Storage Media","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2011-06","conditions":["Complications of Corneal Transplant"],"enrollment":64,"completionDate":"2012-10"},{"nctId":"NCT03936192","phase":"PHASE3","title":"A Parallel-group Active Comparator, Double-blind, Multicenter, Randomized, Double-blind, Phase III Clinical Study","status":"WITHDRAWN","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2019-01","conditions":["Knee Osteoarthritis"],"enrollment":0,"completionDate":"2021-02"},{"nctId":"NCT05321836","phase":"NA","title":"GLUCOSAMINE/CHONDROITIN and PHYSICAL THERAPY EFFECTS ON OLDER POPULATION WITH KNEE OSTEOARTHRITIS","status":"COMPLETED","sponsor":"Muhammad salman, PT","startDate":"2021-07-26","conditions":["Knee Osteoarthritis"],"enrollment":30,"completionDate":"2022-03-25"},{"nctId":"NCT05223946","phase":"NA","title":"Treatment and Companion Diagnostics of Lower Back Pain Using SCENAR and Passive Medical Radiometry (MWR)","status":"COMPLETED","sponsor":"Kyrgyz State Medical Academy","startDate":"2020-09-01","conditions":["Low Back Pain, Recurrent"],"enrollment":55,"completionDate":"2021-08-04"},{"nctId":"NCT03861260","phase":"NA","title":"GAG Replacement vs URethral DIlAtatioN","status":"WITHDRAWN","sponsor":"Hampshire Hospitals NHS Foundation Trust","startDate":"2019-04-30","conditions":["Recurrent Urinary Tract Infection"],"enrollment":0,"completionDate":"2019-10-28"},{"nctId":"NCT04070677","phase":"NA","title":"Clinical Study Assessing the Effect of ZIVEREL® in Cancer Patients","status":"UNKNOWN","sponsor":"Grupo de Investigación Clínica en Oncología Radioterapia","startDate":"2019-06-15","conditions":["Acute Esophagitis"],"enrollment":200,"completionDate":"2023-06-30"},{"nctId":"NCT01415427","phase":"PHASE3","title":"Long-Term Efficacy and Safety Extension Study of BMN 110 in Patients With Mucopolysaccharidosis IVA (Morquio A Syndrome)","status":"COMPLETED","sponsor":"BioMarin Pharmaceutical","startDate":"2011-07","conditions":["Mucopolysaccharidosis IV A","Morquio A Syndrome","MPS IVA"],"enrollment":173,"completionDate":"2016-06-16"},{"nctId":"NCT03945110","phase":"PHASE1,PHASE2","title":"Intravesical Glycosaminoglycan Instillation and Urinary Tract Infection in Acute Spinal Cord Injury","status":"COMPLETED","sponsor":"The University of Western Australia","startDate":"2019-09-18","conditions":["Spinal Cord Injuries"],"enrollment":10,"completionDate":"2021-03-18"},{"nctId":"NCT04470336","phase":"NA","title":"To Assess the Efficacy of Collagen Supplement in Osteoarthritis","status":"COMPLETED","sponsor":"Vedic Lifesciences Pvt. Ltd.","startDate":"2020-07-09","conditions":["Knee Osteoarthritis"],"enrollment":102,"completionDate":"2021-04-12"},{"nctId":"NCT03762408","phase":"NA","title":"Efficacy and Safety of a Intra-articular Injection, ENKO1, in Patients With Symptomatic Knee Osteoarthritis.","status":"COMPLETED","sponsor":"OPKO Health, Inc.","startDate":"2017-12-15","conditions":["Osteoarthritis, Knee"],"enrollment":175,"completionDate":"2020-05-29"},{"nctId":"NCT04063644","phase":"NA","title":"Quality of Life and Visual Acuity of Visglyc Eye Drops on Dry Eye Patients","status":"COMPLETED","sponsor":"OPKO Health, Inc.","startDate":"2019-05-30","conditions":["Dry Eye Syndromes","Cataract"],"enrollment":100,"completionDate":"2020-12-22"},{"nctId":"NCT00291499","phase":"PHASE3","title":"Efficacy Study of Condrosulf in the Treatment of Symptomatic OA of the Hand","status":"COMPLETED","sponsor":"IBSA Institut Biochimique SA","startDate":"2005-06","conditions":["Osteoarthrosis"],"enrollment":163,"completionDate":"2010-08"},{"nctId":"NCT04665804","phase":"NA","title":"Effects of Creatine Supplementation as Compared to Glucosamine/Chondroitin Sulfate Supplementation in Addition to Exercise and Physical Therapy in the Management of Knee Osteoarthritis.","status":"COMPLETED","sponsor":"Foundation University Islamabad","startDate":"2020-06-10","conditions":["Knee Osteoarthritis"],"enrollment":24,"completionDate":"2020-12-06"},{"nctId":"NCT04664712","phase":"NA","title":"Efficacy of Focused Shock Waves Combined With Adjuvant Therapy With Tendon Supplement","status":"COMPLETED","sponsor":"Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari","startDate":"2019-09-11","conditions":["Fasciitis, Plantar"],"enrollment":44,"completionDate":"2020-11-20"},{"nctId":"NCT04654871","phase":"NA","title":"Effects of Glucosamine and Chondroitin Sulfate Supplementation in Addition to Resistance Exercise Training and Manual Therapy in Patients With Knee Osteoarthritis","status":"COMPLETED","sponsor":"Foundation University Islamabad","startDate":"2020-01-01","conditions":["Osteoarthritis","Osteoarthritis, Knee"],"enrollment":24,"completionDate":"2020-11-01"},{"nctId":"NCT03713112","phase":"NA","title":"Efficacy and Feasibility of De-prescribing Rounds in a Singapore Rehabilitative Hospital- a Pilot Randomized Controlled Trial","status":"UNKNOWN","sponsor":"Bright Vision Hospital","startDate":"2018-11-28","conditions":["Deprescribing","Multi-disciplinary","Rounds"],"enrollment":260,"completionDate":"2020-06-30"},{"nctId":"NCT04358120","phase":"NA","title":"A Multicentre Clinical Investigation to Assess Efficacy and Safety of Intra-articular Injections of Hyaluronic Acid Combined With Chondroitin Sulfate in Knee Osteoarthritis","status":"COMPLETED","sponsor":"Fidia Farmaceutici s.p.a.","startDate":"2017-11-28","conditions":["Osteo Arthritis Knee"],"enrollment":74,"completionDate":"2018-09-18"},{"nctId":"NCT04352322","phase":"NA","title":"Effectiveness of Oral Hyaluronic Acid in Knee Osteoarthritis","status":"COMPLETED","sponsor":"China Medical University Hospital","startDate":"2012-01","conditions":["Knee Osteoarthritis"],"enrollment":47,"completionDate":"2016-07"},{"nctId":"NCT03793556","phase":"NA","title":"Evaluation of GERDOFF Efficacy in Combination With Proton Pump Inhibitor","status":"COMPLETED","sponsor":"SOFAR S.p.A.","startDate":"2017-05-05","conditions":["Gastro-oesophageal Reflux Disease"],"enrollment":72,"completionDate":"2018-12-11"},{"nctId":"NCT04268810","phase":"PHASE4","title":"Prospective Trial Comparing Intravesical Chondroitin Sulphate 2% and DMSO in the Treatment of PBS/Interstitial Cystitis","status":"TERMINATED","sponsor":"National Multiple Sclerosis Center","startDate":"2010-03","conditions":["Painful Bladder Syndrome","Interstitial Cystitis"],"enrollment":36,"completionDate":"2013-12-31"},{"nctId":"NCT03725098","phase":"NA","title":"Clinical Study Evaluating the Performance of HEMOBLAST Bellows Compared to FLOSEAL Hemostatic Matrix in Cardiothoracic Operations","status":"COMPLETED","sponsor":"Biom'Up France SAS","startDate":"2019-03-01","conditions":["Cardiothoracic Surgery"],"enrollment":105,"completionDate":"2019-06-28"},{"nctId":"NCT02366676","phase":"PHASE4","title":"Efficacy of IARULIL® in the Treatment of Recurrent Cystitis Refractory to Escherichia Coli Extract","status":"COMPLETED","sponsor":"Samsung Medical Center","startDate":"2014-01","conditions":["Recurrent Cystitis"],"enrollment":105,"completionDate":"2019-10-30"},{"nctId":"NCT03223909","phase":"PHASE4","title":"Efficacy and Safety of the Ophthalmic Solution PRO-087 Versus Systane ® Ultra and Ultra Preservative Free (087LATAMFIV)","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2016-10-13","conditions":["Dry Eye Syndrome"],"enrollment":326,"completionDate":"2018-12-16"},{"nctId":"NCT03633994","phase":"PHASE2","title":"Heparin Intraoperative Instillation for Lower Urinary Tract Symptoms After Benign Hysterectomy","status":"UNKNOWN","sponsor":"The Christ Hospital","startDate":"2018-08-20","conditions":["Lower Urinary Tract Symptoms","Postoperative Urinary Tract Infection"],"enrollment":104,"completionDate":"2020-03-01"},{"nctId":"NCT02830919","phase":"PHASE3","title":"Clinical Study of Non-inferiority With Participants Diagnosed With Primary Knee OA (GLACIAL)","status":"COMPLETED","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2016-12-05","conditions":["Osteoarthritis of Knee"],"enrollment":627,"completionDate":"2019-05-10"},{"nctId":"NCT01966029","phase":"PHASE3","title":"BMN 110 Phase 3B in Australian Patients","status":"COMPLETED","sponsor":"BioMarin Pharmaceutical","startDate":"2013-07","conditions":["Mucopolysaccharidosis IVA (Morquio A Syndrome)"],"enrollment":13,"completionDate":"2016-12"},{"nctId":"NCT03524157","phase":"PHASE1","title":"Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2017-07-17","conditions":["Dry Eye Syndromes","Lubricant Allergy","Tear Disorder"],"enrollment":30,"completionDate":"2018-03-27"},{"nctId":"NCT01813565","phase":"NA","title":"The Efficacy of Additional Intravesical Instillation of Hyaluronic Acid/Chondroitin Sulfate to Transurethral Resection of Bladder Ulcer in Patients With Interstitial Cystitis/Bladder Pain Syndrome.","status":"TERMINATED","sponsor":"Asan Medical Center","startDate":"2013-03-20","conditions":["Interstitial Cystitis"],"enrollment":15,"completionDate":"2016-12-01"},{"nctId":"NCT03971968","phase":"","title":"Observational Study for the Long-Term Effects of a Dermal Substitute on Patients With Facial Burns.","status":"COMPLETED","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2019-01-31","conditions":["Cicatrix"],"enrollment":8,"completionDate":"2019-02-14"},{"nctId":"NCT03963323","phase":"PHASE1","title":"Glucosamine and Chondroitin in Gut in Preventing People From Inflammation","status":"COMPLETED","sponsor":"Fred Hutchinson Cancer Center","startDate":"2018-05-11","conditions":["Healthy Subject"],"enrollment":9,"completionDate":"2019-03-31"},{"nctId":"NCT03924544","phase":"PHASE1","title":"Decorin in Sub Scleral Trabeculectomy","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2019-09-01","conditions":["Primary Open-angle Glaucoma"],"enrollment":52,"completionDate":"2022-01-01"},{"nctId":"NCT03913052","phase":"NA","title":"Intra-articular Viscosupplement Application in Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Istanbul Bilgi University","startDate":"2018-11-02","conditions":["Knee Osteoarthritis"],"enrollment":15,"completionDate":"2019-04-10"},{"nctId":"NCT03827161","phase":"PHASE1","title":"Glucosamine and Chondroitin in Preventing Inflammation in Overweight Patients","status":"COMPLETED","sponsor":"Fred Hutchinson Cancer Center","startDate":"2017-08-01","conditions":["Healthy Subject","Overweight"],"enrollment":2,"completionDate":"2018-12-01"},{"nctId":"NCT03770195","phase":"","title":"Registry Study for the Use of HEMOBLAST™ Bellows in Abdominoplasty","status":"WITHDRAWN","sponsor":"Biom'Up France SAS","startDate":"2018-11-13","conditions":["Abdominoplasty"],"enrollment":0,"completionDate":"2018-12-12"},{"nctId":"NCT03772912","phase":"","title":"Registry for the Use of HEMOBLAST Bellows in Total Knee Arthroplasty","status":"WITHDRAWN","sponsor":"Biom'Up France SAS","startDate":"2018-12","conditions":["Arthroplasty, Replacement, Knee"],"enrollment":0,"completionDate":"2019-12"},{"nctId":"NCT03731793","phase":"PHASE4","title":"Efficacy of Non-animal Chondroitin Sulphate for Overweight Subjects With Knee Ostoarthritis.","status":"COMPLETED","sponsor":"Azienda di Servizi alla Persona di Pavia","startDate":"2017-01-01","conditions":["Knee Osteoarthritis"],"enrollment":60,"completionDate":"2018-10-20"},{"nctId":"NCT02178137","phase":"PHASE4","title":"Effect of Interventions on the Progression of Knee Osteoarthritis","status":"COMPLETED","sponsor":"Indus Hospital and Health Network","startDate":"2014-06","conditions":["Osteo Arthritis of the Knees"],"enrollment":322,"completionDate":"2017-10"},{"nctId":"NCT01657253","phase":"PHASE3","title":"Efficacy and Safety of PRO-148 Versus Systane®, in Patients With Mild to Moderate Dry Eye","status":"COMPLETED","sponsor":"Laboratorios Sophia S.A de C.V.","startDate":"2013-11","conditions":["Dry Eye"],"enrollment":183,"completionDate":"2015-04"},{"nctId":"NCT03355651","phase":"NA","title":"Efficacy and Tolerability of a Nutritional Supplement, Plactive Progen, in ACL Reconstruction","status":"COMPLETED","sponsor":"OPKO Health, Inc.","startDate":"2015-03-09","conditions":["ACL Reconstruction"],"enrollment":80,"completionDate":"2017-03-03"},{"nctId":"NCT01515956","phase":"PHASE2","title":"Study of BMN 110 in Pediatric Patients < 5 Years of Age With Mucopolysaccharidosis IVA (Morquio A Syndrome)","status":"COMPLETED","sponsor":"BioMarin Pharmaceutical","startDate":"2011-10","conditions":["Mucopolysaccharidosis IVA","Morquio A Syndrome","MPS IVA"],"enrollment":15,"completionDate":"2016-02"},{"nctId":"NCT01893905","phase":"PHASE3","title":"Efficacy and Safety of a New Formulation of Chondroitin Sulfate and Glucosamine Sulfate to Treat Knee Osteoarthritis","status":"COMPLETED","sponsor":"Tedec-Meiji Farma, S.A.","startDate":"2013-06","conditions":["Knee Osteoarthritis"],"enrollment":158,"completionDate":"2014-08"},{"nctId":"NCT03209895","phase":"NA","title":"Study to Evaluate the Safety and Efficacy of a Proprietary \"Joint Health\" Dietary Supplement in Subjects With Joint and Connective Tissue Pain","status":"COMPLETED","sponsor":"U.S. Nutraceuticals, LLC","startDate":"2010-10-08","conditions":["Joint Pain"],"enrollment":135,"completionDate":"2011-06-13"},{"nctId":"NCT02079727","phase":"PHASE3","title":"Condrosulf vs Celebrex vs Placebo in the Treatment of Knee OA","status":"COMPLETED","sponsor":"IBSA Institut Biochimique SA","startDate":"2014-06-12","conditions":["Knee Osteoarthritis"],"enrollment":604,"completionDate":"2016-06-16"},{"nctId":"NCT01689363","phase":"PHASE2","title":"Evaluation of the Allergenicity of AMPHADASE INJECTION (Hyaluronidase Injection USP)","status":"COMPLETED","sponsor":"Amphastar Pharmaceuticals, Inc.","startDate":"2012-09","conditions":["Allergic Skin Reaction"],"enrollment":253,"completionDate":"2012-12"},{"nctId":"NCT02304861","phase":"NA","title":"Viscoat Versus Visthesia. A Comparative Study of Post-cataract Endothelial Cell Loss","status":"COMPLETED","sponsor":"Democritus University of Thrace","startDate":"2014-01","conditions":["Cataract"],"enrollment":80,"completionDate":"2014-11"},{"nctId":"NCT02823548","phase":"PHASE4","title":"Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis","status":"UNKNOWN","sponsor":"Bioiberica","startDate":"2016-08","conditions":["Hand Osteoarthritis"],"enrollment":330,"completionDate":"2017-07"},{"nctId":"NCT01354145","phase":"PHASE3","title":"Study of the Effect of Chondroitin Sulfate on Structural Changes in Knee Osteoarthritis Patients Assessed by MRI","status":"COMPLETED","sponsor":"Bioiberica","startDate":"2011-06","conditions":["Knee Osteoarthritis"],"enrollment":194,"completionDate":"2014-10"},{"nctId":"NCT02865031","phase":"PHASE1,PHASE2","title":"Dacorin for Proliferative Vitreoretinopathy","status":"COMPLETED","sponsor":"Cairo University","startDate":"2015-08","conditions":["PVR"],"enrollment":15,"completionDate":"2016-08"},{"nctId":"NCT02821468","phase":"PHASE4","title":"Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN","status":"UNKNOWN","sponsor":"Bioiberica","startDate":"2016-06","conditions":["Osteoarthritis, Knee"],"enrollment":20,"completionDate":"2018-06"},{"nctId":"NCT02562833","phase":"NA","title":"The PLE²NO Self-management and Exercise Program for Knee Osteoarthritis","status":"COMPLETED","sponsor":"Technical University of Lisbon","startDate":"2015-02","conditions":["Osteoarthritis"],"enrollment":80,"completionDate":"2015-10"},{"nctId":"NCT01425853","phase":"PHASE4","title":"Study on Efficacy and Safety of Chondroitin Sulfate + Glucosamine Hydrochloride Versus Celecoxib in Knee Osteoarthritis","status":"COMPLETED","sponsor":"Bioiberica","startDate":"2011-09","conditions":["Knee Osteoarthritis"],"enrollment":606,"completionDate":"2013-05"},{"nctId":"NCT01609062","phase":"PHASE2","title":"Safety and Exercise Study of Two Doses of BMN 110 for Morquio A Syndrome","status":"TERMINATED","sponsor":"BioMarin Pharmaceutical","startDate":"2012-04","conditions":["Mucopolysaccharidosis IVA","Morquio A Syndrome","MPS IVA"],"enrollment":25,"completionDate":"2014-11"},{"nctId":"NCT01697319","phase":"PHASE2","title":"Efficacy and Safety Study of BMN 110 for Morquio A Syndrome Patients Who Have Limited Ambulation","status":"TERMINATED","sponsor":"BioMarin Pharmaceutical","startDate":"2012-08","conditions":["Mucopolysaccharidosis IVA","Morquio A Syndrome","MPS IVA"],"enrollment":16,"completionDate":"2014-10"},{"nctId":"NCT01275066","phase":"PHASE3","title":"A Double-Blind Study to Evaluate the Efficacy and Safety of BMN 110 in Patients With Mucopolysaccharidosis IVA (Morquio A Syndrome)","status":"COMPLETED","sponsor":"BioMarin Pharmaceutical","startDate":"2011-02","conditions":["MPS IV A"],"enrollment":177,"completionDate":"2012-08"},{"nctId":"NCT01682694","phase":"NA","title":"Glucosamine and Chondroitin Effects","status":"COMPLETED","sponsor":"Fred Hutchinson Cancer Center","startDate":"2012-09","conditions":["Inflammation"],"enrollment":20,"completionDate":"2013-08"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000148837","MMSL":"20864","VUID":"4021426","CHEBI":"CHEBI:37397","VANDF":"4021426","RXNORM":"2473","UMLSCUI":"C0008466","ChEMBL_ID":"CHEMBL2108922","DRUGBANK_ID":"DB09301","PUBCHEM_CID":"24766","SNOMEDCT_US":"4104007"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":11615,"therapeuticAreas":["Ophthalmology"],"atcClassification":{"source":"DrugCentral","atcCode":"M01AX25","allCodes":["M01AX25"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 28","pmid":"41902922","title":"Impact of Intravesical Chondroitin Sulfate Instillation on Sexual Function in Women with Interstitial Cystitis/Bladder Pain Syndrome.","journal":"International urogynecology journal"},{"date":"2026 Feb 27","pmid":"41901230","title":"Influence of Propolis-Containing Nonwoven PLGA Dressings on Dermatan and Chondroitin Sulfate Dynamics During Burn-Wound Healing.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2026 Mar 25","pmid":"41895487","title":"Delivery growth factors by layer-by-layer assembly in nanofibers for enhancing bone defect repairment along with neurogenesis.","journal":"International journal of biological macromolecules"},{"date":"2026 Mar 27","pmid":"41894675","title":"Profiling of the Golgi Apparatus Proteome in Living Cells Using Nanophotosensitizer-Mediated Photocatalytic Proximity Labeling.","journal":"Analytical chemistry"},{"date":"2026 Mar 20","pmid":"41892974","title":"Identification of an Unpredicted GAG-PUL in Roseihalotalea indica gen. nov. sp. nov. TK19036(T) and Characterization of Novel GAG-Lyases with Unique Substrate Specificities.","journal":"Marine drugs"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"discontinued","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chondroitin Sulphate is a small molecule drug in the chondroitin sulfate class, originally developed by an unknown entity. It is currently used for surgical procedures on the eye, such as operation on the lens. The commercial status of Chondroitin Sulphate is unclear, with unknown patent status and generic manufacturers. Key safety considerations are not well-documented. Further research is needed to fully understand its pharmacology and clinical applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}