{"id":"chondrocelect-implantation","safety":{"commonSideEffects":[{"rate":null,"effect":"Graft failure or hypertrophy"},{"rate":null,"effect":"Joint effusion"},{"rate":null,"effect":"Infection at biopsy or implantation site"},{"rate":null,"effect":"Pain or swelling"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The therapy involves harvesting healthy cartilage cells from the patient's own knee, expanding them in culture over several weeks, and then implanting them back into the cartilage defect under a periosteal flap. This allows the patient's own chondrocytes to regenerate functional hyaline cartilage tissue, restoring the damaged joint surface and potentially halting or slowing osteoarthritis progression.","oneSentence":"ChondroCelect is an autologous cultured chondrocyte implant that replaces damaged cartilage by transplanting the patient's own expanded cartilage cells into the defect site.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:05:46.097Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Symptomatic cartilage defects of the knee (Grade III-IV, ICRS classification)"}]},"trialDetails":[{"nctId":"NCT00414700","phase":"PHASE3","title":"RCT of ChondroCelect® (in an ACI Procedure) vs Microfracture in the Repair of Cartilage Defects of the Knee","status":"COMPLETED","sponsor":"TiGenix n.v.","startDate":"2002-02","conditions":"Articular Cartilage Lesion of the Femoral Condyle","enrollment":118}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CCI"],"phase":"phase_3","status":"active","brandName":"ChondroCelect implantation","genericName":"ChondroCelect implantation","companyName":"TiGenix n.v.","companyId":"tigenix-n-v","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ChondroCelect implantation is a treatment for articular cartilage lesions of the femoral condyle, involving the implantation of autologous cartilage cells that have been expanded ex vivo. This treatment modality falls under somatic cell supplemental therapy, where autologous cells are used to repair damaged cartilage.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}