{"id":"choline-magnesium-trisalicylate","rwe":[{"pmid":"30000947","year":"2006","title":"Choline Magnesium Salicylate.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"31643296","year":"2012","title":"Trisalicylate.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"27659510","year":"2017","title":"Choline-magnesium trisalicylate modulates acute myelogenous leukemia gene expression during induction chemotherapy.","finding":"","journal":"Leukemia & lymphoma","studyType":"Clinical Study"},{"pmid":"19010875","year":"2008","title":"Nuclear factor-kappaB modulation in patients undergoing induction chemotherapy for acute myelogenous leukemia.","finding":"","journal":"Clinical cancer research : an official journal of the American Association for Cancer Research","studyType":"Clinical Study"},{"pmid":"14680616","year":"2004","title":"Adverse respiratory reactions to aspirin and nonsteroidal anti-inflammatory drugs.","finding":"","journal":"Current allergy and asthma reports","studyType":"Clinical Study"}],"tags":[{"label":"choline magnesium trisalicylate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Oral","category":"route"},{"label":"Liquid","category":"form"},{"label":"Active","category":"status"},{"label":"Fever","category":"indication"},{"label":"Osteoarthritis","category":"indication"},{"label":"Pain","category":"indication"},{"label":"Rheumatoid arthritis","category":"indication"},{"label":"Shoulder Tendonitis","category":"indication"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antifungal Agents","category":"pharmacology"},{"label":"Antimetabolites","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Dermatologic Agents","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"},{"label":"Hypolipidemic Agents","category":"pharmacology"},{"label":"Keratolytic Agents","category":"pharmacology"},{"label":"Lipid Regulating Agents","category":"pharmacology"},{"label":"Lipotropic Agents","category":"pharmacology"},{"label":"Nootropic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"discontinued","safety":{"commonSideEffects":[{"effect":"irreversible hearing loss and/or tinnitus","drugRate":"reported","severity":"unknown"},{"effect":"mental confusion and hallucinations","drugRate":"reported","severity":"unknown"},{"effect":"hepatitis","drugRate":"reported","severity":"unknown"},{"effect":"elevated hepatic transaminases","drugRate":"reported","severity":"unknown"},{"effect":"esophagitis","drugRate":"reported","severity":"unknown"},{"effect":"asthma","drugRate":"reported","severity":"unknown"},{"effect":"erythema multiforme","drugRate":"reported","severity":"unknown"},{"effect":"urticaria","drugRate":"reported","severity":"unknown"},{"effect":"ecchymoses","drugRate":"reported","severity":"unknown"},{"effect":"duodenal ulceration","drugRate":"reported","severity":"unknown"}],"contraindications":["Anemia","Anemia due to enzyme deficiency","Blood coagulation disorder","Body fluid retention","Breastfeeding (mother)","Cardiovascular event risk","Chronic renal failure syndrome","Diabetes mellitus","Disease of liver","Disorder of cardiovascular system","Factor II deficiency","Gastritis","Gastroesophageal reflux disease","Gastrointestinal hemorrhage","Gastrointestinal ulcer","Gout","Hemophilia","Hepatic failure","Hypermagnesemia","Kidney disease","Nasal polyp","Pregnancy, function","Thrombocytopenic disorder","Thrombotic thrombocytopenic purpura","Thyrotoxicosis"],"specialPopulations":{"Pregnancy":"Use in Pregnancy. Pregnancy Category C. Animal reproduction studies have not been conducted with Choline Magnesium Trisalicylate Liquid. It is also not known whether Choline Magnesium Trisalicylate Liquid can cause fetal harm when administered to pregnant woman or can affect reproduction capacity. Choline Magnesium Trisalicylate Liquid should be given to pregnant woman only if clearly needed. Because of the known effect of other salicylate drug products on the fetal cardiovascular system (closur","Geriatric use":"The elderly may be prone to more side effects from salicylates than younger patients due to an age-related decline in renal clearance and/or increased use of concomitant medication. The elderly are more likely than younger patients to be taking number of medications, some of which may affect the plasma protein binding of salicylate and thus increase the amount of free salicylate.","Paediatric use":"In children, Choline Magnesium Trisalicylate Liquid is indicated for conditions requiring anti-inflammatory or analgesic action-such as juvenile rheumatoid arthritis and other appropriate conditions."}},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"trilisate","offLabel":[],"synonyms":["trisalicylate choline","choline magnesium trisalicylate","trilisate"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Trilisate","ecosystem":[{"indication":"Fever","otherDrugs":[{"name":"codeine","slug":"codeine","company":"Ani Pharms"},{"name":"dextromethorphan","slug":"dextromethorphan","company":"Ani Pharms"},{"name":"guaifenesin","slug":"guaifenesin","company":"Reckitt Benckiser"},{"name":"ibuprofen","slug":"ibuprofen","company":""}],"globalPrevalence":2000000000},{"indication":"Osteoarthritis","otherDrugs":[{"name":"aceclofenac","slug":"aceclofenac","company":""},{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"celecoxib","slug":"celecoxib","company":"Gd Searle"},{"name":"diclofenac","slug":"diclofenac","company":""}],"globalPrevalence":null},{"indication":"Pain","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"bromfenac","slug":"bromfenac","company":"Bausch And Lomb Inc"},{"name":"butorphanol","slug":"butorphanol","company":""},{"name":"caffeine","slug":"caffeine","company":"Novartis"}],"globalPrevalence":1500000000},{"indication":"Rheumatoid arthritis","otherDrugs":[{"name":"abatacept","slug":"abatacept","company":"Bristol Myers Squibb"},{"name":"aceclofenac","slug":"aceclofenac","company":""},{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"adalimumab","slug":"adalimumab","company":"Abbvie Inc"}],"globalPrevalence":18000000},{"indication":"Shoulder Tendonitis","otherDrugs":[{"name":"indomethacin","slug":"indomethacin","company":""},{"name":"magnesium salicylate","slug":"magnesium-salicylate","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"choline magnesium trisalicylate","explanation":"Imagine your body has a fire alarm system that goes off when there's an injury or infection. Prostaglandins are like the alarm signals that tell your body to send in the pain and inflammation fighters. Trilisate blocks these alarm signals, so your body doesn't send in the pain and inflammation fighters as much, which helps to reduce pain and inflammation.","oneSentence":"Trilisate works by blocking the production of prostaglandins, hormone-like substances that cause pain and inflammation.","technicalDetail":"Trilisate exerts its analgesic and anti-inflammatory effects by inhibiting the enzyme cyclooxygenase (COX), which is responsible for converting arachidonic acid into prostaglandins."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4662","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CHOLINE%20MAGNESIUM%20TRISALICYLATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHOLINE MAGNESIUM TRISALICYLATE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:36:07.531966","biosimilars":[],"competitors":[],"genericName":"choline magnesium trisalicylate","indications":{"approved":[{"name":"Fever","source":"DrugCentral","snomedId":386661006,"regulator":"FDA","eligibility":"Adults and children; no specific age or stage restrictions mentioned","usPrevalence":null,"globalPrevalence":2000000000,"prevalenceMethod":"curated","prevalenceSource":"Common symptom, not a disease"},{"name":"Osteoarthritis","source":"DrugCentral","snomedId":396275006,"regulator":"FDA","eligibility":"Adults and children; no specific age or stage restrictions mentioned"},{"name":"Pain","source":"DrugCentral","snomedId":22253000,"regulator":"FDA","eligibility":"Adults and children; no specific age or stage restrictions mentioned","usPrevalence":51600000,"globalPrevalence":1500000000,"prevalenceMethod":"curated","prevalenceSource":"CDC, 2023"},{"name":"Rheumatoid arthritis","source":"DrugCentral","snomedId":69896004,"regulator":"FDA","usPrevalence":1500000,"globalPrevalence":18000000,"prevalenceMethod":"curated","prevalenceSource":"Lancet Rheumatology, 2023"},{"name":"Shoulder Tendonitis","source":"DrugCentral","snomedId":"","regulator":"FDA","eligibility":"Adults and children; no specific age or stage restrictions mentioned"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT02144675","phase":"PHASE2","title":"Choline Magnesium Trisalicylate and Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia","status":"COMPLETED","sponsor":"Rutgers, The State University of New Jersey","startDate":"2009-01","conditions":["Adult Acute Megakaryoblastic Leukemia (M7)","Adult Acute Minimally Differentiated Myeloid Leukemia (M0)","Adult Acute Monoblastic Leukemia (M5a)","Adult Acute Monocytic Leukemia (M5b)","Adult Acute Myeloblastic Leukemia With Maturation (M2)","Adult Acute Myeloblastic Leukemia Without Maturation (M1)","Adult Acute Myeloid Leukemia in Remission","Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities","Adult Acute Myeloid Leukemia With Del(5q)","Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)","Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)","Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)","Adult Acute Myelomonocytic Leukemia (M4)","Adult Erythroleukemia (M6a)","Adult Pure Erythroid Leukemia (M6b)","Recurrent Adult Acute Myeloid Leukemia","Untreated Adult Acute Myeloid Leukemia"],"enrollment":27,"completionDate":"2016-04-26"},{"nctId":"NCT01009931","phase":"PHASE2","title":"Phase II Study of TPA Plus Dexamethasone & CMT in Hematologic Malignancies","status":"TERMINATED","sponsor":"Rutgers, The State University of New Jersey","startDate":"2011-03","conditions":["Leukemia"],"enrollment":1,"completionDate":"2014-09"},{"nctId":"NCT00156299","phase":"PHASE1","title":"Gene Expression During Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With Choline Magnesium Trisalicylate","status":"TERMINATED","sponsor":"Rutgers, The State University of New Jersey","startDate":"2003-03","conditions":["Leukemia"],"enrollment":15,"completionDate":"2008-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Oral","formulation":"Liquid","formulations":[{"form":"LIQUID","route":"ORAL","productName":"CHOLINE MAGNESIUM TRISALICYLATE"}]},"crossReferences":{"MMSL":"4382","NDDF":"001951","UNII":"DJJ95FJP1H","CHEBI":"CHEBI:15354","VANDF":"4017699","RXNORM":"215799","UMLSCUI":"C0719064","ChEMBL_ID":"CHEMBL4297727","DRUGBANK_ID":"DB01401","PDB_CHEM_ID":" SAL","PUBCHEM_CID":"54682045","SNOMEDCT_US":"111156002","MESH_DESCRIPTOR_UI":"D002794","MESH_SUPPLEMENTAL_RECORD_UI":"C017959"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":38,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"2006","pmid":"30000947","title":"Choline Magnesium Salicylate.","journal":""},{"date":"2012","pmid":"31643296","title":"Trisalicylate.","journal":""},{"date":"2017 May","pmid":"27659510","title":"Choline-magnesium trisalicylate modulates acute myelogenous leukemia gene expression during induction chemotherapy.","journal":"Leukemia & lymphoma"},{"date":"2008 Nov 15","pmid":"19010875","title":"Nuclear factor-kappaB modulation in patients undergoing induction chemotherapy for acute myelogenous leukemia.","journal":"Clinical cancer research : an official journal of the American Association for Cancer Research"},{"date":"2004 Jan","pmid":"14680616","title":"Adverse respiratory reactions to aspirin and nonsteroidal anti-inflammatory drugs.","journal":"Current allergy and asthma reports"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"discontinued","companyName":"","companyId":"","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Trilisate, also known as choline magnesium trisalicylate, is a small molecule drug in the salicylate class. It is used to treat various conditions including fever, osteoarthritis, pain, rheumatoid arthritis, and shoulder tendonitis. The commercial status of Trilisate is unknown, but it is likely available as a generic medication. Key safety considerations include potential gastrointestinal side effects and interactions with other medications. As a salicylate, Trilisate works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation.","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"SA","regulator":"SFDA","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":null},{"country_code":"BR","regulator":"ANVISA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MX","regulator":"COFEPRIS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AR","regulator":"ANMAT","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TR","regulator":"TITCK","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IN","regulator":"CDSCO","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TH","regulator":"FDA-TH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MY","regulator":"NPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"PH","regulator":"FDA-PH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CO","regulator":"INVIMA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"ZA","regulator":"SAHPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TW","regulator":"TFDA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"HK","regulator":"DH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CA","regulator":"Health Canada","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}