{"id":"cholestyramine-powder","safety":{"commonSideEffects":[{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Bloating"},{"rate":null,"effect":"Flatulence"}]},"_chembl":{"chemblId":"CHEMBL1201625","moleculeType":"Unknown"},"_dailymed":{"setId":"408ad775-9a1b-43cc-b122-226ade73e0c2","title":"CHOLESTYRAMINE POWDER FOR SUSPENSION POWDER, FOR SUSPENSION [BRYANT RANCH PREPACK]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By binding bile acids in the gastrointestinal tract, cholestyramine prevents their enterohepatic circulation and reabsorption. This forces the liver to synthesize new bile acids from cholesterol, thereby reducing serum cholesterol levels. The drug also reduces LDL cholesterol and can lower triglycerides in some patients.","oneSentence":"Cholestyramine is an anion exchange resin that binds bile acids in the intestine, preventing their reabsorption and increasing fecal excretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T06:00:06.007Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypercholesterolemia"},{"name":"Pruritus associated with biliary obstruction"}]},"trialDetails":[{"nctId":"NCT05966727","phase":"NA","title":"Exploratory Evaluation of the Effect of Cholestyramine on Serum Levels of POPs in Obese Female Patients","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire de Nice","startDate":"2025-03-19","conditions":"Obesity, Abdominal, Diabetes, Bariatric Surgery Candidate","enrollment":20},{"nctId":"NCT04235205","phase":"PHASE2","title":"Efficacy and Safety of Elobixibat in Combination With Cholestyramine for Nonalcoholic Fatty Liver Disease","status":"COMPLETED","sponsor":"Yokohama City University","startDate":"2020-01-29","conditions":"Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis","enrollment":102},{"nctId":"NCT03303053","phase":"PHASE3","title":"Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism","status":"UNKNOWN","sponsor":"Clinical Research Centre, Malaysia","startDate":"2017-05-11","conditions":"Hyperthyroidism, Graves Disease","enrollment":135},{"nctId":"NCT01122108","phase":"PHASE4","title":"Comparison of Colesevelam Hydrogen Chloride (HCl) Powder For Oral Suspension Versus Generic Cholestyramine Through Use of the Bile Acid Sequestrant Acceptability (BASA) Scale","status":"COMPLETED","sponsor":"Louisville Metabolic and Atherosclerosis Research Center","startDate":"2010-04","conditions":"Healthy","enrollment":42},{"nctId":"NCT00677469","phase":"NA","title":"Low Doses of Cholestyramine in the Treatment of Hyperthyroidism","status":"COMPLETED","sponsor":"Shiraz University of Medical Sciences","startDate":"2007-07","conditions":"Graves Disease","enrollment":45}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[{"date":"20211019","type":"ORIG","sponsor":"ALKEM LABS LTD","applicationNumber":"ANDA211856"}],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Questran"],"phase":"marketed","status":"active","brandName":"Cholestyramine Powder","genericName":"Cholestyramine Powder","companyName":"Centre Hospitalier Universitaire de Nice","companyId":"centre-hospitalier-universitaire-de-nice","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cholestyramine is an anion exchange resin that binds bile acids in the intestine, preventing their reabsorption and increasing fecal excretion. Used for Hypercholesterolemia, Pruritus associated with biliary obstruction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}