{"id":"cholestagel-colesevelam","safety":{"commonSideEffects":[{"rate":"11–12%","effect":"Constipation"},{"rate":"8–10%","effect":"Dyspepsia"},{"rate":"5–8%","effect":"Nausea"},{"rate":"5–7%","effect":"Abdominal pain"},{"rate":"4–6%","effect":"Flatulence"}]},"_chembl":{"chemblId":"CHEMBL1201473","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By binding bile acids in the gastrointestinal tract, colesevelam reduces the enterohepatic circulation of bile acids. This triggers increased hepatic conversion of cholesterol to bile acids to replenish the bile acid pool, thereby lowering serum LDL cholesterol levels. The drug may also improve glycemic control through mechanisms involving altered bile acid signaling and gut microbiota changes.","oneSentence":"Colesevelam is a bile acid sequestrant that binds bile acids in the intestine, preventing their reabsorption and increasing their fecal excretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:24:32.793Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypercholesterolemia (elevated LDL cholesterol)"},{"name":"Type 2 diabetes mellitus (adjunctive therapy for glycemic control)"}]},"trialDetails":[{"nctId":"NCT03009916","phase":"PHASE4","title":"Bileacid Malabsorption and GLP-1 Secretion","status":"COMPLETED","sponsor":"University Hospital, Gentofte, Copenhagen","startDate":"2016-03","conditions":"Bileacid Malabsorption","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"\"cholestagel®\" (Colesevelam)","genericName":"\"cholestagel®\" (Colesevelam)","companyName":"University Hospital, Gentofte, Copenhagen","companyId":"university-hospital-gentofte-copenhagen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Colesevelam is a bile acid sequestrant that binds bile acids in the intestine, preventing their reabsorption and increasing their fecal excretion. Used for Hypercholesterolemia (elevated LDL cholesterol), Type 2 diabetes mellitus (as adjunctive therapy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}