{"id":"chlorure-de-sodium-0-9","brandName":"Chlorure de sodium 0.9%","genericName":"Chlorure de sodium 0.9%","companyId":"centre-hospitalier-universitaire-dijon","companyName":"Centre Hospitalier Universitaire Dijon","phase":"marketed","status":"active","modality":"Small molecule","aliases":[],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Chlorure de sodium 0.9%, commonly known as normal saline, is a sterile, isotonic solution of sodium chloride in water used primarily for hydration and to maintain fluid balance. It is widely used in hospitals and clinics for intravenous administration. The solution helps to restore electrolyte balance and is often used in emergency settings to treat dehydration or hypovolemia. Despite its widespread use, it is important to monitor patients for potential side effects such as fluid overload and electrolyte imbalances.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This solution contains sodium and chloride ions in physiologic concentrations (0.9% w/v), matching the osmolarity of blood plasma. It is used intravenously or topically to restore intravascular volume, maintain electrolyte balance, and serve as a vehicle for drug delivery or wound irrigation. The isotonic nature prevents cell lysis or crenation.","oneSentence":"Sodium chloride 0.9% is an isotonic saline solution that replaces fluid and electrolytes in the body.","_ai_confidence":"high"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Hypernatremia (with excessive use)"},{"rate":null,"effect":"Fluid overload"},{"rate":null,"effect":"Phlebitis (at infusion site)"}]},"trials":[],"indications":{"approved":[{"name":"Hypovolemia and dehydration"},{"name":"Electrolyte replacement"},{"name":"Vehicle for intravenous drug administration"},{"name":"Wound irrigation and saline dressing"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}