{"id":"chlorthenoxazine","rwe":[{"pmid":"2284308","year":"1990","title":"[Synthesis, structure elucidation and biological activity of thio- analogs of drugs with the examples of chlorthenoxazine and amobarbital].","finding":"","journal":"Die Pharmazie","studyType":"Clinical Study"},{"pmid":"7159513","year":"1982","title":"[Determination of aminophenazone and chlorthenoxazine in a dosage form using HPLC].","finding":"","journal":"Bollettino chimico farmaceutico","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Poly [ADP-ribose] polymerase 1","category":"target"},{"label":"PARP1","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"apirazin","offLabel":[],"synonyms":["chlorthenoxazine","apirazin","chlorethylbenzmethoxazone","ossapirina","ossazone","piroxina","reumagrip","valmorin"],"timeline":[],"aiSummary":"Apirazin is a small molecule with the synonyms AP 67, AP-67, APIRAZIN, CHLORTHENOXAZIN(E), CHLORTHENOXAZINE, and CLORTENOXAZINA.","approvals":[],"brandName":"Apirazin","ecosystem":[],"mechanism":{"target":"Poly [ADP-ribose] polymerase 1","targets":[{"gene":"PARP1","source":"DrugCentral","target":"Poly [ADP-ribose] polymerase 1","protein":"Poly [ADP-ribose] polymerase 1"}],"modality":"Small Molecule","explanation":"Think of PARP1 like a repair crew that fixes damaged DNA. When PARP1 is inhibited, the repair crew can't fix the damage, which can lead to cell death. This can be beneficial in treating certain types of cancer, but it also means that healthy cells may be more susceptible to damage.","oneSentence":"Apirazin works by inhibiting the activity of PARP1, a protein that plays a key role in DNA repair and cell death.","technicalDetail":"Apirazin binds to the PARP1 active site, preventing the enzyme from catalyzing the transfer of ADP-ribose units to target proteins, thereby inhibiting PARP1-mediated DNA repair and cell death pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3707","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHLORTHENOXAZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:35:38.896015","biosimilars":[],"competitors":[{"drugName":"ciclopirox","drugSlug":"ciclopirox","fdaApproval":"1982-12-30","genericCount":17,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"niraparib","drugSlug":"niraparib","fdaApproval":"2017-03-27","patentExpiry":"Mar 27, 2038","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"olaparib","drugSlug":"olaparib","fdaApproval":"2014-12-19","patentExpiry":"Sep 8, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"rucaparib","drugSlug":"rucaparib","fdaApproval":"2016-12-19","patentExpiry":"Feb 10, 2031","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"talazoparib tosylate","drugSlug":"talazoparib-tosylate","fdaApproval":"2018-10-16","patentExpiry":"Oct 20, 2031","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"chlorthenoxazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"ciclopirox","brandName":"ciclopirox","genericName":"ciclopirox","approvalYear":"1982","relationship":"same-target"},{"drugId":"niraparib","brandName":"niraparib","genericName":"niraparib","approvalYear":"2017","relationship":"same-target"},{"drugId":"olaparib","brandName":"olaparib","genericName":"olaparib","approvalYear":"2014","relationship":"same-target"},{"drugId":"rucaparib","brandName":"rucaparib","genericName":"rucaparib","approvalYear":"2016","relationship":"same-target"},{"drugId":"talazoparib-tosylate","brandName":"talazoparib tosylate","genericName":"talazoparib tosylate","approvalYear":"2018","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"004336","UNII":"KA0B657LV3","CHEBI":"CHEBI:134882","INN_ID":"962","RXNORM":"20891","UMLSCUI":"C0055478","ChEMBL_ID":"CHEMBL124815","PUBCHEM_CID":"8602"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"recentPublications":[{"date":"1990 Sep","pmid":"2284308","title":"[Synthesis, structure elucidation and biological activity of thio- analogs of drugs with the examples of chlorthenoxazine and amobarbital].","journal":"Die Pharmazie"},{"date":"1982 Sep","pmid":"7159513","title":"[Determination of aminophenazone and chlorthenoxazine in a dosage form using HPLC].","journal":"Bollettino chimico farmaceutico"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}