{"id":"chlorthalidone-with-potassium-chloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorthalidone blocks the sodium-chloride cotransporter in the kidney's distal convoluted tubule, promoting urinary sodium and water excretion to reduce blood volume and blood pressure. The combination with potassium chloride mitigates hypokalemia, a common adverse effect of thiazide diuretics, by replacing potassium lost in urine.","oneSentence":"Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule, while potassium chloride supplementation replaces electrolytes lost during diuresis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:02.954Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Edema associated with congestive heart failure or renal disease"}]},"trialDetails":[{"nctId":"NCT07238400","phase":"PHASE2","title":"Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia","status":"NOT_YET_RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-12-01","conditions":"Hypertension","enrollment":90},{"nctId":"NCT04519164","phase":"PHASE4","title":"Aldosterone, the Mineralocorticoid Receptor, and 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LV Mass in Patients With CKD","status":"UNKNOWN","sponsor":"University Hospital Birmingham","startDate":"2014-06","conditions":"Renal Insufficiency, Chronic, Cardio-Renal Syndrome","enrollment":154},{"nctId":"NCT00670787","phase":"PHASE3","title":"Combination Pill of Losartan Potassium and Hydrochlorothiazide for Improvement of Medication Compliance Trial","status":"COMPLETED","sponsor":"Kyushu University","startDate":"2008-06","conditions":"Hypertension","enrollment":207}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["hygroton"],"phase":"marketed","status":"active","brandName":"Chlorthalidone with potassium chloride","genericName":"Chlorthalidone with potassium chloride","companyName":"Brigham and Women's Hospital","companyId":"brigham-and-women-s-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule, while potassium chloride supplementation replaces electrolytes lost during diuresis. Used for Hypertension, Edema associated with congestive heart failure or renal disease.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}