{"id":"chlorthalidone-plus-amiloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperkalemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorthalidone inhibits the Na-Cl cotransporter in the distal convoluted tubule, promoting sodium and water excretion and reducing blood volume and vascular resistance. Amiloride blocks epithelial sodium channels in the collecting duct, preventing potassium loss and counteracting the hypokalemia caused by chlorthalidone. The combination provides synergistic antihypertensive and diuretic effects while maintaining electrolyte balance.","oneSentence":"Chlorthalidone is a thiazide-like diuretic that reduces sodium reabsorption in the distal convoluted tubule, while amiloride is a potassium-sparing diuretic that blocks sodium channels in the collecting duct, together lowering blood pressure and reducing fluid overload.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:05:44.085Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Edema associated with congestive heart failure or renal disease"}]},"trialDetails":[{"nctId":"NCT02847338","phase":"PHASE4","title":"Comparison of Optimal Hypertension Regimens","status":"COMPLETED","sponsor":"Cambridge University Hospitals NHS Foundation Trust","startDate":"2016-11","conditions":"Hypertension","enrollment":940},{"nctId":"NCT01191450","phase":"PHASE3","title":"Safety and Efficacy of Chlorthalidone + Amiloride to Elderly Patients Treatment With Arterial Hypertension","status":"COMPLETED","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2011-08","conditions":"Arterial Hypertension","enrollment":246},{"nctId":"NCT04467931","phase":"","title":"ACEI or ARB and COVID-19 Severity and Mortality in US Veterans","status":"COMPLETED","sponsor":"University of Utah","startDate":"2020-01-19","conditions":"Hypertension, COVID","enrollment":22213},{"nctId":"NCT03928145","phase":"PHASE3","title":"Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension.","status":"UNKNOWN","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2019-11-13","conditions":"Hypertension","enrollment":84},{"nctId":"NCT02896621","phase":"PHASE3","title":"Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2014-12-07","conditions":"Hypertension, Sleep Apnea","enrollment":69},{"nctId":"NCT01896661","phase":"PHASE3","title":"Effect of Antihypertensive Agents Over Sleep Apnea","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2014-12","conditions":"Hypertension, Obstructive Sleep Apnea","enrollment":53},{"nctId":"NCT00971165","phase":"PHASE3","title":"Diuretics and Angiotensin-Receptor Blocker Agents in Patients With Stage I Hypertension","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2010-07","conditions":"Hypertension, Cardiovascular Disease","enrollment":655},{"nctId":"NCT00970931","phase":"PHASE3","title":"Hypertension Prevention in Pre-Hypertensive Individuals","status":"COMPLETED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2010-07","conditions":"Pre-hypertension, Hypertension, Cardiovascular Disease","enrollment":730}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Chlo+Ami","diuretics","diuretic"],"phase":"phase_3","status":"active","brandName":"Chlorthalidone plus amiloride","genericName":"Chlorthalidone plus amiloride","companyName":"Hospital de Clinicas de Porto Alegre","companyId":"hospital-de-clinicas-de-porto-alegre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorthalidone is a thiazide-like diuretic that reduces sodium reabsorption in the distal convoluted tubule, while amiloride is a potassium-sparing diuretic that blocks sodium channels in the collecting duct, together lowering blood pressure and reducing fluid overload. Used for Hypertension, Edema associated with congestive heart failure or renal disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}