{"id":"chlorproguanil-dapsone-plus-artesunate","safety":{"commonSideEffects":[{"rate":null,"effect":"Hemolytic anemia (particularly in G6PD-deficient patients)"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL361497","moleculeType":"Small molecule","molecularWeight":"384.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorproguanil and dapsone are antifolate agents that inhibit dihydrofolate reductase, blocking nucleotide synthesis in malaria parasites. Artesunate is an artemisinin derivative that generates reactive oxygen species and damages parasite mitochondria. The combination provides synergistic antimalarial activity and helps overcome resistance to individual components.","oneSentence":"This combination antimalarial drug works by inhibiting parasite dihydrofolate reductase (via chlorproguanil and dapsone) and disrupting mitochondrial function (via artesunate) to kill Plasmodium parasites through multiple pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:43:23.525Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Uncomplicated malaria caused by Plasmodium falciparum"},{"name":"Malaria treatment in areas with drug-resistant parasites"}]},"trialDetails":[{"nctId":"NCT00519467","phase":"PHASE2","title":"Safety and Efficacy Dose of Artesunate Used in Combination With LAPDAP Treatment of Uncomplicated Falciparum Malaria","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2003-06","conditions":"Malaria","enrollment":120},{"nctId":"NCT00393679","phase":"PHASE3","title":"Evaluation of 4 Artemisinin-based Combinations for Treating Uncomplicated Malaria in African Children","status":"COMPLETED","sponsor":"Institute of Tropical Medicine, Belgium","startDate":"2007-07","conditions":"Fever, Malaria","enrollment":4112},{"nctId":"NCT00111163","phase":"NA","title":"Intermittent Preventive Treatment With Antimalarials in Kenyan Infants","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2004-03","conditions":"Malaria, Anemia","enrollment":1516},{"nctId":"NCT00164359","phase":"PHASE4","title":"Amodiaquine Plus Artesunate Versus Lapdap Plus Artesunate in the Treatment of Uncomplicated P. Falciparum Malaria in Malawi","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2005-04","conditions":"Malaria, Falciparum","enrollment":212},{"nctId":"NCT00164710","phase":"PHASE4","title":"Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi","status":"COMPLETED","sponsor":"Centers for Disease Control and Prevention","startDate":"2005-04","conditions":"Malaria, Falciparum","enrollment":365}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"chlorproguanil-dapsone plus artesunate","genericName":"chlorproguanil-dapsone plus artesunate","companyName":"Centers for Disease Control and Prevention","companyId":"centers-for-disease-control-and-prevention","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination antimalarial drug works by inhibiting parasite dihydrofolate reductase (via chlorproguanil and dapsone) and disrupting mitochondrial function (via artesunate) to kill Plasmodium parasites through multiple pathways. Used for Uncomplicated malaria caused by Plasmodium falciparum, Malaria treatment in areas with drug-resistant parasites.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}