{"id":"chlorphenoxamine","rwe":[{"pmid":"41253499","year":"2025","title":"Markovnikov-Selective Hydroboration of Aryl Alkenes Catalyzed by Quaternary Ammonium Salts.","finding":"","journal":"Journal of the American Chemical Society","studyType":"Clinical Study"},{"pmid":"40974210","year":"2026","title":"The Tianma Anshen Dingxuan Formula Regulates Gut Microbiota and Metabolites in a Rat Model of Vertigo With Liver Yang Hyperactivity.","finding":"","journal":"Phytochemical analysis : PCA","studyType":"Clinical Study"},{"pmid":"40108219","year":"2025","title":"Smart green spectrophotometric estimation and content uniformity testing of chlorphenoxamine HCl and caffeine in bulk forms and combined pharmaceutical formulation.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"39030644","year":"2024","title":"Novel RP-HPLC-DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances.","finding":"","journal":"BMC chemistry","studyType":"Clinical Study"},{"pmid":"25545351","year":"2015","title":"Validated green high-performance liquid chromatographic methods for the determination of coformulated pharmaceuticals: a comparison with reported conventional methods.","finding":"","journal":"Journal of separation science","studyType":"Clinical Study"}],"tags":[{"label":"chlorphenoxamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D04AA34","category":"atc"},{"label":"Active","category":"status"},{"label":"Cholinergic Agents","category":"pharmacology"},{"label":"Cholinergic Antagonists","category":"pharmacology"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Antagonists","category":"pharmacology"},{"label":"Muscarinic Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["chlorphenoxamine hydrochloride","chlorphenoxamine"],"offLabel":[],"synonyms":["chlorphenoxamine hydrochloride","chlorphenoxamine"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"chlorphenoxamine","explanation":"Imagine your brain is like a busy city with many different signals and messengers. Chlorphenoxamine is like a traffic cop that helps regulate the flow of these signals by blocking certain receptors. This can help calm down the brain and reduce symptoms of certain conditions.","oneSentence":"Chlorphenoxamine is thought to work by blocking certain receptors in the brain.","technicalDetail":"Chlorphenoxamine is a non-selective adrenergic receptor antagonist, which means it blocks the action of certain neurotransmitters like norepinephrine and epinephrine at their receptors in the brain."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/617","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHLORPHENOXAMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:34:49.849043","biosimilars":[],"competitors":[{"drugName":"mepyramine","drugSlug":"mepyramine","fdaApproval":"1973-08-07","relationship":"same-class"},{"drugName":"tripelennamine","drugSlug":"tripelennamine","fdaApproval":"1948-02-19","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"promethazine","drugSlug":"promethazine","fdaApproval":"1951-03-29","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clemastine","drugSlug":"clemastine","fdaApproval":"1977-02-25","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pheniramine","drugSlug":"pheniramine","fdaApproval":"1994-06-08","relationship":"same-class"},{"drugName":"diphenhydramine","drugSlug":"diphenhydramine","fdaApproval":"1946-03-04","genericCount":56,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"chlorphenoxamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"mepyramine","brandName":"mepyramine","genericName":"mepyramine","approvalYear":"1973","relationship":"same-class"},{"drugId":"tripelennamine","brandName":"tripelennamine","genericName":"tripelennamine","approvalYear":"1948","relationship":"same-class"},{"drugId":"promethazine","brandName":"promethazine","genericName":"promethazine","approvalYear":"1951","relationship":"same-class"},{"drugId":"clemastine","brandName":"clemastine","genericName":"clemastine","approvalYear":"1977","relationship":"same-class"},{"drugId":"pheniramine","brandName":"pheniramine","genericName":"pheniramine","approvalYear":"1994","relationship":"same-class"},{"drugId":"diphenhydramine","brandName":"diphenhydramine","genericName":"diphenhydramine","approvalYear":"1946","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001651","UNII":"3UVD77BP8R","CHEBI":"CHEBI:135288","INN_ID":"885","RXNORM":"20881","UMLSCUI":"C0055468","ChEMBL_ID":"CHEMBL2110774","KEGG_DRUG":"D07198","DRUGBANK_ID":"DB09007","PUBCHEM_CID":"6475","SNOMEDCT_US":"109232002","SECONDARY_CAS_RN":"562-09-4","MESH_SUPPLEMENTAL_RECORD_UI":"C100100"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":26,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"D04AA34","allCodes":["D04AA34","R06AA06","R06AA56"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Dec 3","pmid":"41253499","title":"Markovnikov-Selective Hydroboration of Aryl Alkenes Catalyzed by Quaternary Ammonium Salts.","journal":"Journal of the American Chemical Society"},{"date":"2026 Jan","pmid":"40974210","title":"The Tianma Anshen Dingxuan Formula Regulates Gut Microbiota and Metabolites in a Rat Model of Vertigo With Liver Yang Hyperactivity.","journal":"Phytochemical analysis : PCA"},{"date":"2025 Mar 19","pmid":"40108219","title":"Smart green spectrophotometric estimation and content uniformity testing of chlorphenoxamine HCl and caffeine in bulk forms and combined pharmaceutical formulation.","journal":"Scientific reports"},{"date":"2024 Jul 19","pmid":"39030644","title":"Novel RP-HPLC-DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances.","journal":"BMC chemistry"},{"date":"2015 Mar","pmid":"25545351","title":"Validated green high-performance liquid chromatographic methods for the determination of coformulated pharmaceuticals: a comparison with reported conventional methods.","journal":"Journal of separation science"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"CHLORPHENOXAMINE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorphenoxamine is a small molecule drug in the chlorphenoxamine class, but its target and exact mechanism of action are unknown. It is not clear if it is FDA-approved or commercially available. There is limited information available on its pharmacokinetic properties, such as half-life and bioavailability. Chlorphenoxamine's approved indications are also unknown. Further research is needed to understand its clinical use and safety profile.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}