{"id":"chlorpheniramine-maleate-syrup","safety":{"commonSideEffects":[{"rate":"30-50","effect":"Drowsiness/sedation"},{"rate":"10-20","effect":"Dry mouth"},{"rate":"5-15","effect":"Dizziness"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Anticholinergic effects (urinary retention, constipation)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorpheniramine is a first-generation antihistamine that competitively antagonizes histamine at H1 receptors on various tissues, preventing histamine-mediated allergic responses. This reduces symptoms such as urticaria, pruritus, rhinitis, and other allergic manifestations. As a first-generation agent, it crosses the blood-brain barrier and commonly causes sedation.","oneSentence":"Chlorpheniramine maleate blocks histamine H1 receptors to reduce allergic symptoms and itching.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:05:44.094Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Urticaria and pruritus"},{"name":"Allergic reactions"}]},"trialDetails":[{"nctId":"NCT03879772","phase":"PHASE3","title":"Dose-Ranging Study of Mometasone Furoate (MK-0887/SCH 032088) Nasal Spray in the Treatment of Children (Ages 6-11) With Seasonal Allergic Rhinitis (C95-161)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"1996-03-12","conditions":"Rhinitis, Allergic, Seasonal","enrollment":679}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":39,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ChlorTrimeton Syrup"],"phase":"phase_3","status":"active","brandName":"Chlorpheniramine maleate syrup","genericName":"Chlorpheniramine maleate syrup","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorpheniramine maleate blocks histamine H1 receptors to reduce allergic symptoms and itching. Used for Allergic rhinitis, Urticaria and pruritus, Allergic reactions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}