{"id":"chlorpheniramine-maleate","rwe":[{"pmid":"41882895","year":"2026","title":"Anaphylaxis and Fulminant Disseminated Intravascular Coagulation Due to Loxoprofen.","finding":"","journal":"Internal medicine (Tokyo, Japan)","studyType":"Clinical Study"},{"pmid":"41800096","year":"2026","title":"Rhabdomyolysis secondary to chlorpheniramine maleate toxicity: a case report.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"},{"pmid":"41754896","year":"2026","title":"Microwave-Assisted Wet Granulation for Engineering Rice Starch-Mannitol Co-Processed Excipients for Direct Compression of Orally Disintegrating Tablets.","finding":"","journal":"Pharmaceutics","studyType":"Clinical Study"},{"pmid":"41625513","year":"2026","title":"Validated RP-HPLC-UV Method for Simultaneous Quantification of Aminophenazone, Dipyrine, and Chlorpheniramine Maleate in Pharmaceutical Formulations Considering Dipyrine Decomposition.","finding":"","journal":"International journal of analytical chemistry","studyType":"Clinical Study"},{"pmid":"41458965","year":"2025","title":"Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"}],"_fda":{"id":"43810cbb-1d34-d1ff-e063-6294a90a2b40","set_id":"01a1a91e-04ba-4526-8946-10483932b30c","openfda":{"unii":["V1Q0O9OJ9Z"],"route":["ORAL"],"rxcui":["1363309"],"spl_id":["43810cbb-1d34-d1ff-e063-6294a90a2b40"],"brand_name":["SPRINSOL"],"spl_set_id":["01a1a91e-04ba-4526-8946-10483932b30c"],"package_ndc":["51467-101-01","51467-101-02"],"product_ndc":["51467-101"],"generic_name":["CHLORPHENIRAMINE MALEATE"],"product_type":["HUMAN OTC DRUG"],"substance_name":["CHLORPHENIRAMINE MALEATE"],"manufacturer_name":["FORTUNE PHARMACAL COMPANY LIMITED"],"application_number":["M012"],"is_original_packager":[true]},"purpose":["Purpose Antihistamine"],"version":"3","warnings":["Warnings Ask a doctor before use if you have a breathing problem such as emphysema or chronic bronchitis glaucoma difficulty in urination due to enlargement of the prostate gland"],"questions":["Questions or comments? (888) 221-3496 M-F 9 am to 5 pm you may also report serious side effects to this phone number"],"when_using":["When using this product do not exceed recommended dosage unless directed by a physician may cause excitability especially in children use caution when driving or operating machinery avoid alcoholic beverages may cause drowsiness; alcohol, sedatives, and tranquilizers may increase the drowsiness effect"],"effective_time":"20251113","active_ingredient":["Active ingredients (in each tablet) Chlorpheniramine maleate 4 mg"],"inactive_ingredient":["Inactive ingredients colloidal silicon dioxide, corn starch, FD C red no. 40 aluminum lake, lactose monohydrate, magnesium stearate, povidone K30, sodium starch glycolate"],"indications_and_usage":["Uses temporarily relieves these symptoms due to hay fever (allergic rhinitis) or other upper respiratory allergies: sneezing runny nose itching of the nose or throat itchy, watery eyes"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers"],"other_safety_information":["Other information keep tightly sealed protect from light store between 20 to 25 C (68 to 77 F)"],"dosage_and_administration":["Directions adults and children 12 years of age and over: take 1 tablet every 4 to 6 hours, not to exceed 6 tablets (24 mg) in 24 hours, or as directed by a doctor children under 12 years of age: consult a doctor"],"spl_product_data_elements":["SPRINSOL Chlorpheniramine maleate SILICON DIOXIDE STARCH, CORN FD&C RED NO. 40 LACTOSE MONOHYDRATE MAGNESIUM STEARATE POVIDONE K30 SODIUM STARCH GLYCOLATE TYPE A POTATO CHLORPHENIRAMINE MALEATE CHLORPHENIRAMINE FORTUNE"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use."],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away"],"package_label_principal_display_panel":["Sprinsol Safely Sealed NDC 51467-101-02 Chlorpheniramine maleate - Antihistamine temporarily relieves these symptoms due to hay fever (allergic rhinitis) or other upper respiratory allergies: sneezing runny nose itching of the nose or throat itchy, watery eyes 36 Tablets In Individually Sealed Strip Respiratory Series IMAGE OF CARTON"]},"tags":[{"label":"Histamine-1 Receptor Antagonist","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Histamine H1 receptor","category":"target"},{"label":"HRH1","category":"gene"},{"label":"SLC6A4","category":"gene"},{"label":"HRH4","category":"gene"},{"label":"R06AB04","category":"atc"},{"label":"Oral","category":"route"},{"label":"Aerosol","category":"form"},{"label":"Capsule","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Established","category":"status"},{"label":"Allergic conjunctivitis","category":"indication"},{"label":"Allergic rhinitis","category":"indication"},{"label":"Common cold","category":"indication"},{"label":"Dermatographic urticaria","category":"indication"},{"label":"Influenza-like symptoms","category":"indication"},{"label":"Itching of skin","category":"indication"},{"label":"Bayer Healthcare Llc","category":"company"},{"label":"Approved 1950s","category":"decade"},{"label":"Anti-Allergic Agents","category":"pharmacology"},{"label":"Antipruritics","category":"pharmacology"},{"label":"Dermatologic Agents","category":"pharmacology"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Antagonists","category":"pharmacology"},{"label":"Histamine H1 Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"5123 reports"},{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"3819 reports"},{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"3598 reports"},{"date":"","signal":"HEADACHE","source":"FDA FAERS","actionTaken":"3452 reports"},{"date":"","signal":"DYSPNOEA","source":"FDA FAERS","actionTaken":"3389 reports"},{"date":"","signal":"DIARRHOEA","source":"FDA FAERS","actionTaken":"2989 reports"},{"date":"","signal":"PAIN","source":"FDA FAERS","actionTaken":"2543 reports"},{"date":"","signal":"DIZZINESS","source":"FDA FAERS","actionTaken":"2522 reports"},{"date":"","signal":"OFF LABEL USE","source":"FDA FAERS","actionTaken":"2502 reports"},{"date":"","signal":"COUGH","source":"FDA FAERS","actionTaken":"2209 reports"}],"commonSideEffects":[{"effect":"Nausea","drugRate":"","severity":"common","organSystem":""},{"effect":"Vomiting","drugRate":"","severity":"common","organSystem":""},{"effect":"Sedation","drugRate":"","severity":"common","organSystem":""},{"effect":"Drowsiness","drugRate":"","severity":"common","organSystem":""},{"effect":"Mental clouding","drugRate":"","severity":"common","organSystem":""},{"effect":"Lethargy","drugRate":"","severity":"common","organSystem":""},{"effect":"Impairment of mental and physical performance","drugRate":"","severity":"common","organSystem":""},{"effect":"Dizziness","drugRate":"","severity":"common","organSystem":""},{"effect":"Mood changes","drugRate":"","severity":"common","organSystem":""},{"effect":"Constipation","drugRate":"","severity":"common","organSystem":""},{"effect":"Anxiety","drugRate":"","severity":"common","organSystem":""},{"effect":"Fear","drugRate":"","severity":"common","organSystem":""},{"effect":"Dysphoria","drugRate":"","severity":"common","organSystem":""},{"effect":"Euphoria","drugRate":"","severity":"common","organSystem":""},{"effect":"Psychic dependence","drugRate":"","severity":"common","organSystem":""},{"effect":"Dryness of the pharynx","drugRate":"","severity":"common","organSystem":""},{"effect":"Rash","drugRate":"","severity":"common","organSystem":""},{"effect":"Pruritus","drugRate":"","severity":"common","organSystem":""}],"contraindications":["Achalasia of esophagus","Acidosis","Acute Thromboembolic Stroke","Acute abdominal pain","Acute erosive gastritis","Acute exacerbation of asthma","Acute hepatitis","Acute nephropathy","Acute pancreatitis","Acute tuberculosis","Agoraphobia","Alcohol intoxication","Alcohol withdrawal delirium","Alcoholism","Anemia","Anemia due to enzyme deficiency","Angle-closure glaucoma","Arterial thrombosis","Arteriosclerotic vascular disease","Asthenia","Atony of colon","Autonomic dysreflexia","Benign intracranial hypertension","Benign prostatic hyperplasia","Bladder outflow obstruction"],"specialPopulations":{"Labor":"Use of codeine during labor can produce respiratory depression in the neonate.","Pregnancy":"Use in Pregnancy: Pregnancy Category C. Animal reproduction studies have not been conducted with CPM/PE/DM Syrup. It is not known whether these products can cause fetal harm when administered to pregnant woman or affect reproduction capacity. Give to pregnant woman only if clearly needed.","Geriatric use":"Geriatric patients taking sympathomimetics may be more likely to experience confusion, hallucinations, seizures, and central nervous system depression. Geriatric patients may also be more sensitive to the effects, especially to the vasopressor effects, of sympathomimetic amines.","Paediatric use":"Safety and effectiveness of Atuss(R) DS TannateSuspension in pediatric patients under the age of two years have not been established. Pseudoephedrine may be more likely to cause side effects in infants, especially newborn and premature infants, than in older children and adults.","Nursing mothers":"The risk of infant exposure to codeine and morphine through breast milk should be weighed against the benefits of breastfeeding for both the mother and the baby.","Pediatric patients":"Safety and effectiveness of this drug product has not been established for patients under 18."},"seriousAdverseEvents":[{"effect":"Death","drugRate":"","severity":"serious"},{"effect":"Respiratory depression","drugRate":"","severity":"serious"},{"effect":"Fatal respiratory depression","drugRate":"","severity":"serious"},{"effect":"Urinary retention","drugRate":"","severity":"serious"},{"effect":"Ureteral spasm","drugRate":"","severity":"serious"},{"effect":"Spasm of vesical sphincters","drugRate":"","severity":"serious"},{"effect":"Tightness of the chest","drugRate":"","severity":"serious"}]},"trials":[],"aliases":[],"company":"Bayer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CHLORPHENIRAMINE MALEATE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:35:22.525772+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:35:28.526473+00:00"},"regulatory.us":{"url":"","method":"api_direct","source":"FDA Drugs@FDA","rawText":"","confidence":1,"sourceType":"fda_drugsfda","retrievedAt":"2026-04-20T00:35:21.132991+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHLORPHENIRAMINE MALEATE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:35:29.307723+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:35:19.693780+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:35:19.693839+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T00:35:31.318646+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL180454/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:35:30.145526+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"M012","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T00:35:19.693850+00:00"}},"allNames":"tussionex pennkinetic","offLabel":[],"synonyms":["chlorphenamine","chloropheniramine","chlorophenylpyridamine","chloroprophenpyridamine","chlorpheniramine","chlorprophenpyridamine","chlorpheniramine maleate","chlorpheniramine tannate","chlorpheniramine polistirex"],"timeline":[{"date":"1950-01-01","type":"neutral","source":"FDA Orange Book","milestone":"Rights transferred from BAYER HEALTHCARE LLC to Bayer Healthcare Llc"},{"date":"1950-08-15","type":"positive","source":"DrugCentral","milestone":"FDA approval (Bayer Healthcare Llc)"},{"date":"1994-11-18","type":"positive","source":"FDA Orange Book","milestone":"Efidac 24 Chlorpheniramine Maleate approved — 16MG"}],"aiSummary":"Tussionex Pennkinetic (Chlorpheniramine Maleate) is a small molecule histamine-1 receptor antagonist developed by Bayer Healthcare LLC. It targets the histamine H1 receptor to treat various allergic conditions, including allergic conjunctivitis, rhinitis, and skin itching. Originally approved by the FDA in 1950, it is now off-patent with 26 generic manufacturers. The drug has a half-life of 22 hours and bioavailability of 41%. It is used to alleviate symptoms such as nasal congestion, discharge, and itching.","brandName":"Tussionex Pennkinetic","ecosystem":[{"indication":"Allergic conjunctivitis","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alcaftadine","slug":"alcaftadine","company":"Allergan"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":null},{"indication":"Allergic rhinitis","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"antazoline","slug":"antazoline","company":"Novartis"},{"name":"astemizole","slug":"astemizole","company":""}],"globalPrevalence":null},{"indication":"Common cold","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"azatadine","slug":"azatadine","company":""}],"globalPrevalence":null},{"indication":"Dermatographic urticaria","otherDrugs":[{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"antazoline","slug":"antazoline","company":"Novartis"},{"name":"azatadine","slug":"azatadine","company":""},{"name":"brompheniramine","slug":"brompheniramine","company":""}],"globalPrevalence":68000000},{"indication":"Influenza-like symptoms","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"brompheniramine","slug":"brompheniramine","company":""},{"name":"caffeine","slug":"caffeine","company":"Novartis"},{"name":"codeine","slug":"codeine","company":"Ani Pharms"}],"globalPrevalence":null},{"indication":"Itching of skin","otherDrugs":[{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"allantoin","slug":"allantoin","company":""},{"name":"ammonium lactate","slug":"ammonium-lactate","company":"Ranbaxy"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":null},{"indication":"Nasal congestion","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":null},{"indication":"Nasal discharge","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":30000000}],"mechanism":{"target":"Histamine H1 receptor","novelty":"First-in-class","targets":[{"gene":"HRH1","source":"DrugCentral","target":"Histamine H1 receptor","protein":"Histamine H1 receptor"},{"gene":"SLC6A4","source":"DrugCentral","target":"Sodium-dependent serotonin transporter","protein":"Sodium-dependent serotonin transporter"},{"gene":"HRH4","source":"DrugCentral","target":"Histamine H4 receptor","protein":"Histamine H4 receptor"},{"gene":"SLC6A3","source":"DrugCentral","target":"Sodium-dependent dopamine transporter","protein":"Sodium-dependent dopamine transporter"},{"gene":"KCNH2","source":"DrugCentral","target":"Potassium voltage-gated channel subfamily H member 2","protein":"Potassium voltage-gated channel subfamily H member 2"},{"gene":"SLC6A2","source":"DrugCentral","target":"Sodium-dependent noradrenaline transporter","protein":"Sodium-dependent noradrenaline transporter"},{"gene":"HTR2B","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2B","protein":"5-hydroxytryptamine receptor 2B"},{"gene":"SCN1A","source":"DrugCentral","target":"Sodium channel alpha subunits; brain (Types I, II, III)","protein":"Sodium channel protein type 1 subunit alpha"},{"gene":"SCN2A","source":"DrugCentral","target":"Sodium channel alpha subunits; brain (Types I, II, III)","protein":"Sodium channel protein type 2 subunit alpha"},{"gene":"SCN3A","source":"DrugCentral","target":"Sodium channel alpha subunits; brain (Types I, II, III)","protein":"Sodium channel protein type 3 subunit alpha"}],"moaClass":"Histamine H1 Receptor Antagonists","modality":"Small Molecule","drugClass":"Histamine-1 Receptor Antagonist","explanation":"","oneSentence":"","technicalDetail":"Chlorpheniramine maleate competitively inhibits the histamine H1 receptor, preventing the binding of histamine and subsequent activation of downstream signaling pathways that lead to allergic symptoms."},"commercial":{"launchDate":"1950","_launchSource":"DrugCentral (FDA 1950-08-15, BAYER HEALTHCARE LLC)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/616","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CHLORPHENIRAMINE%20MALEATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHLORPHENIRAMINE MALEATE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T02:46:09.865496","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:35:33.077732+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"brompheniramine","drugSlug":"brompheniramine","fdaApproval":"1957-08-23","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"dexchlorpheniramine","drugSlug":"dexchlorpheniramine","fdaApproval":"1981-07-14","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pheniramine","drugSlug":"pheniramine","fdaApproval":"1994-06-08","relationship":"same-class"},{"drugName":"dexbrompheniramine","drugSlug":"dexbrompheniramine","fdaApproval":"1963-10-18","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"chlorpheniramine maleate","indications":{"approved":[{"name":"Allergic conjunctivitis","source":"DrugCentral","snomedId":473460002,"regulator":"FDA"},{"name":"Allergic rhinitis","source":"DrugCentral","snomedId":61582004,"regulator":"FDA"},{"name":"Common cold","source":"DrugCentral","snomedId":82272006,"regulator":"FDA"},{"name":"Dermatographic urticaria","source":"DrugCentral","snomedId":7632005,"regulator":"FDA","usPrevalence":null,"globalPrevalence":68000000,"prevalenceMethod":"curated","prevalenceSource":"Allergy, 2020 (PMID:31494963)"},{"name":"Influenza-like symptoms","source":"DrugCentral","snomedId":315642008,"regulator":"FDA"},{"name":"Itching of skin","source":"DrugCentral","snomedId":418363000,"regulator":"FDA"},{"name":"Nasal congestion","source":"DrugCentral","snomedId":68235000,"regulator":"FDA"},{"name":"Nasal discharge","source":"DrugCentral","snomedId":64531003,"regulator":"FDA","usPrevalence":null,"globalPrevalence":30000000,"prevalenceMethod":"curated","prevalenceSource":"Influenza Other Respir Viruses, 2023 (PMID:36824394)"},{"name":"Seasonal allergic rhinitis","source":"DrugCentral","snomedId":367498001,"regulator":"FDA"},{"name":"Sneezing","source":"DrugCentral","snomedId":76067001,"regulator":"FDA","eligibility":"Not specified"},{"name":"Urticaria","source":"DrugCentral","snomedId":126485001,"regulator":"FDA","usPrevalence":null,"globalPrevalence":68000000,"prevalenceMethod":"curated","prevalenceSource":"Allergy, 2020 (PMID:31494963)"},{"name":"Vasomotor rhinitis","source":"DrugCentral","snomedId":8229003,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"currentOwner":"Bayer Healthcare Llc","drugCategory":"established","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"brompheniramine","brandName":"brompheniramine","genericName":"brompheniramine","approvalYear":"1957","relationship":"same-class"},{"drugId":"dexchlorpheniramine","brandName":"dexchlorpheniramine","genericName":"dexchlorpheniramine","approvalYear":"1981","relationship":"same-class"},{"drugId":"pheniramine","brandName":"pheniramine","genericName":"pheniramine","approvalYear":"1994","relationship":"same-class"},{"drugId":"dexbrompheniramine","brandName":"dexbrompheniramine","genericName":"dexbrompheniramine","approvalYear":"1963","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT03301454","phase":"PHASE2","title":"Study of the Interest of Pursuing or Not the Chemotherapy for Patients With Metastatic Esophageal Cancer","status":"TERMINATED","sponsor":"Centre Oscar Lambret","startDate":"2018-08-20","conditions":["Esophageal Cancer, Squamous Cell"],"enrollment":15,"completionDate":"2022-07-05"},{"nctId":"NCT02604199","phase":"PHASE2","title":"A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Negative, Chronic Hepatitis B Virus (HBV) Infection","status":"TERMINATED","sponsor":"Arrowhead Pharmaceuticals","startDate":"2015-09","conditions":["Hepatitis B"],"enrollment":58,"completionDate":"2017-01"},{"nctId":"NCT02738008","phase":"PHASE2","title":"Extension Study of the Safety and Efficacy of Multi-dose Intravenous ARC-520 in Patients With Chronic Hepatitis B (HBV) Infection","status":"TERMINATED","sponsor":"Arrowhead Pharmaceuticals","startDate":"2016-03","conditions":["Hepatitis B"],"enrollment":12,"completionDate":"2016-12"},{"nctId":"NCT02577029","phase":"PHASE2","title":"Study of ARC-520 With or Without Other Drugs Used in the Treatment of Chronic Chronic Hepatitis B Virus (HBV)","status":"TERMINATED","sponsor":"Arrowhead Pharmaceuticals","startDate":"2015-12","conditions":["Hepatitis B","Hepatitis D"],"enrollment":79,"completionDate":"2016-12"},{"nctId":"NCT02065336","phase":"PHASE2","title":"A Multicenter Study to Determine the Depth and Duration of Hepatitis B Surface Antigen (HBsAg) Reduction After Single or Multiple Doses of ARC-520, in Combination With Entecavir in Patients With Chronic Hepatitis B Virus (HBV) Infection","status":"TERMINATED","sponsor":"Arrowhead Pharmaceuticals","startDate":"2014-03","conditions":["Hepatitis B, Chronic"],"enrollment":58,"completionDate":"2017-01"},{"nctId":"NCT02604212","phase":"PHASE2","title":"A Multi-dose Study of ARC-520 in Patients With Hepatitis B 'e' Antigen (HBeAg) Positive, Chronic Hepatitis B Virus Infection","status":"TERMINATED","sponsor":"Arrowhead Pharmaceuticals","startDate":"2015-11","conditions":["Hepatitis B"],"enrollment":32,"completionDate":"2016-12"},{"nctId":"NCT02797522","phase":"PHASE1","title":"A Study of ARC-521 Injection in Normal Adult Volunteers and Patients With Chronic Hepatitis B (CHB)","status":"TERMINATED","sponsor":"Arrowhead Pharmaceuticals","startDate":"2016-06","conditions":["Hepatitis B"],"enrollment":47,"completionDate":"2016-11"},{"nctId":"NCT04688736","phase":"PHASE2","title":"Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.","status":"RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2021-01-01","conditions":["Allergic Transfusion Reaction"],"enrollment":6642,"completionDate":"2027-06-30"},{"nctId":"NCT06995274","phase":"NA","title":"Umbilical Cord Blood Therapy in a Child With Eosinophilic Duodenitis and Autism Spectrum Disorder: a Case Study","status":"NOT_YET_RECRUITING","sponsor":"Bundang CHA Hospital","startDate":"2025-06-01","conditions":["Autism Spectrum Disorder","Eosinophilic Gastrointestinal Disorders"],"enrollment":1,"completionDate":"2025-12-31"},{"nctId":"NCT05338099","phase":"PHASE1","title":"Determine the Safety and Dose of EN001 in Patients With Duchenne Muscular 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