{"id":"chloroxine","rwe":[{"pmid":"40856911","year":"2025","title":"Correction: Chloroxine inhibits pancreatic cancer progression through targeted antagonization of the PI3K/AKT/mTOR signaling pathway.","finding":"","journal":"Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico","studyType":"Clinical Study"},{"pmid":"39134284","year":"2024","title":"Zn(II) enhances the antimicrobial effect of chloroxine and structural analogues against drug-resistant ESKAPE pathogens in vitro.","finding":"","journal":"Biochemical pharmacology","studyType":"Clinical Study"},{"pmid":"37848695","year":"2024","title":"Chloroxine inhibits pancreatic cancer progression through targeted antagonization of the PI3K/AKT/mTOR signaling pathway.","finding":"","journal":"Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico","studyType":"Clinical Study"},{"pmid":"37493629","year":"2023","title":"Broad susceptibility of Candida auris strains to 8-hydroxyquinolines and mechanisms of resistance.","finding":"","journal":"mBio","studyType":"Clinical Study"},{"pmid":"37366936","year":"2023","title":"Insight into the Mode of Action of 8-Hydroxyquinoline-Based Blockers on the Histamine Receptor 2.","finding":"","journal":"Biosensors","studyType":"Clinical Study"}],"tags":[{"label":"chloroxine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Arachidonate 12-lipoxygenase, 12S-type","category":"target"},{"label":"ALOX12","category":"gene"},{"label":"ALOX15","category":"gene"},{"label":"ALOX5","category":"gene"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Pityriasis simplex","category":"indication"},{"label":"Seborrheic dermatitis","category":"indication"},{"label":"Approved 1970s","category":"decade"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antifungal Agents","category":"pharmacology"}],"phase":"marketed","safety":{"contraindications":["Denuded skin"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CHLOROXINE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:21:31.668146+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:21:36.785766+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHLOROXINE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:21:37.079013+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: DNA inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:21:38.118099+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1200596/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:21:37.780007+00:00"}},"allNames":"clofuzid","offLabel":[],"synonyms":["chloroxine","chlofucid","chloroxyquinoline","clofuzid","dichlorohydroxyquinoline","dichloroquinolinol","dichloroxin","endiaron","quixalin","quinolor"],"timeline":[{"date":"1976-10-19","type":"positive","source":"DrugCentral","milestone":"FDA approval"}],"aiSummary":"Clofuzine, also known as Chloroxine, is a small molecule drug that targets Arachidonate 12-lipoxygenase, 12S-type. 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