{"id":"chlorothiazide-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL842","moleculeType":"Small molecule","molecularWeight":"295.73"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a thiazide diuretic, chlorothiazide blocks the thiazide-sensitive sodium-chloride cotransporter (NCC) in the kidney's distal convoluted tubule. This reduces fluid volume in the body and lowers blood pressure. The drug also has mild vasodilatory properties that contribute to its antihypertensive effect.","oneSentence":"Chlorothiazide inhibits sodium chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of sodium, chloride, and water.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:58.198Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Edema associated with congestive heart failure"},{"name":"Edema associated with renal disease"}]},"trialDetails":[{"nctId":"NCT03574857","phase":"PHASE4","title":"Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance","status":"TERMINATED","sponsor":"University of Virginia","startDate":"2018-06-01","conditions":"Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure Acute","enrollment":5}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Diuril"],"phase":"marketed","status":"active","brandName":"Chlorothiazide Injection","genericName":"Chlorothiazide Injection","companyName":"University of Virginia","companyId":"university-of-virginia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorothiazide inhibits sodium chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of sodium, chloride, and water. Used for Hypertension, Edema associated with congestive heart failure, Edema associated with renal disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}