{"id":"chloroquine-profilaxis","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea and gastrointestinal disturbance"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Visual disturbances"},{"rate":null,"effect":"Retinopathy (with prolonged use)"},{"rate":null,"effect":"Cardiomyopathy (rare, with chronic use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chloroquine is a quinoline antimalarial that concentrates in the acidic food vacuole of malaria parasites, preventing the detoxification of heme and disrupting DNA/RNA synthesis. This leads to parasite death and is effective for both treatment and chemoprophylaxis of malaria. The drug also has immunomodulatory properties that may contribute to its antimalarial efficacy.","oneSentence":"Chloroquine inhibits parasite growth by accumulating in parasite food vacuoles and interfering with heme detoxification and nucleic acid synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:01.944Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria prophylaxis in endemic regions"},{"name":"Malaria treatment (Plasmodium vivax, P. ovale, P. malariae, and chloroquine-sensitive P. falciparum)"}]},"trialDetails":[{"nctId":"NCT00290420","phase":"PHASE4","title":"Prevention of P. Vivax Malaria During Pregnancy in Bolivia","status":"WITHDRAWN","sponsor":"Institut de Recherche pour le Developpement","startDate":"2006-03","conditions":"Malaria","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["prevention of plasmodium vivax malaria harmfull effects on birth outcomes"],"phase":"marketed","status":"active","brandName":"Chloroquine profilaxis","genericName":"Chloroquine profilaxis","companyName":"Institut de Recherche pour le Developpement","companyId":"institut-de-recherche-pour-le-developpement","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chloroquine inhibits parasite growth by accumulating in parasite food vacuoles and interfering with heme detoxification and nucleic acid synthesis. Used for Malaria prophylaxis in endemic regions, Malaria treatment (Plasmodium vivax, P. ovale, P. malariae, and chloroquine-sensitive P. falciparum).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}