{"id":"chloropyramine","rwe":[{"pmid":"40760915","year":"2025","title":"Innovative strategies for cisplatin desensitization in hyperthermic intraperitoneal chemotherapy of ovarian cancer.","finding":"","journal":"Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners","studyType":"Clinical Study"},{"pmid":"39760915","year":"2025","title":"Single-cell RNA-sequencing and genome-wide Mendelian randomisation along with abundant machine learning methods identify a novel B cells signature in gastric cancer.","finding":"","journal":"Discover oncology","studyType":"Clinical Study"},{"pmid":"38904559","year":"2024","title":"[Oral sedation in pediatric outpatient dentistry].","finding":"","journal":"Stomatologiia","studyType":"Clinical Study"},{"pmid":"38896318","year":"2024","title":"Suprastin (Chloropyramine) Causes Proarrhythmic Deterioration of Excitation Conduction, Depolarization and Potentiates Adrenergic Automaticity in the Pulmonary Veins Myocardium.","finding":"","journal":"Bulletin of experimental biology and medicine","studyType":"Clinical Study"},{"pmid":"37113769","year":"2023","title":"pyHeart4Fish: Chamber-specific heart phenotype quantification of zebrafish in high-content screens.","finding":"","journal":"Frontiers in cell and developmental biology","studyType":"Clinical Study"}],"tags":[{"label":"chloropyramine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Focal adhesion kinase 1","category":"target"},{"label":"PTK2","category":"gene"},{"label":"D04AA09","category":"atc"},{"label":"Active","category":"status"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Antagonists","category":"pharmacology"},{"label":"Histamine H1 Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":76.318,"date":"","count":10,"signal":"Vaccination site reaction","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=76)"},{"llr":69.545,"date":"","count":9,"signal":"Carcinoembryonic antigen","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=70)"},{"llr":68.788,"date":"","count":9,"signal":"Carbohydrate antigen 15-3","source":"DrugCentral FAERS","actionTaken":"Reported 9 times (LLR=69)"},{"llr":65.502,"date":"","count":10,"signal":"Pleural neoplasm","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=66)"},{"llr":61.451,"date":"","count":11,"signal":"Cranial nerve disorder","source":"DrugCentral FAERS","actionTaken":"Reported 11 times (LLR=61)"},{"llr":60.444,"date":"","count":11,"signal":"Bacteriuria","source":"DrugCentral FAERS","actionTaken":"Reported 11 times (LLR=60)"},{"llr":56.754,"date":"","count":11,"signal":"Right ventricular dilatation","source":"DrugCentral FAERS","actionTaken":"Reported 11 times (LLR=57)"},{"llr":47.037,"date":"","count":11,"signal":"Thyroid mass","source":"DrugCentral FAERS","actionTaken":"Reported 11 times (LLR=47)"},{"llr":47.016,"date":"","count":19,"signal":"Body temperature increased","source":"DrugCentral FAERS","actionTaken":"Reported 19 times (LLR=47)"}],"commonSideEffects":[{"effect":"Vaccination site reaction","drugRate":"LLR 76","severity":"common"},{"effect":"Carcinoembryonic antigen","drugRate":"LLR 70","severity":"common"},{"effect":"Carbohydrate antigen 15-3","drugRate":"LLR 69","severity":"common"},{"effect":"Pleural neoplasm","drugRate":"LLR 66","severity":"common"},{"effect":"Cranial nerve disorder","drugRate":"LLR 61","severity":"common"},{"effect":"Bacteriuria","drugRate":"LLR 60","severity":"common"},{"effect":"Right ventricular dilatation","drugRate":"LLR 57","severity":"common"},{"effect":"Thyroid mass","drugRate":"LLR 47","severity":"common"},{"effect":"Body temperature increased","drugRate":"LLR 47","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"halopyramine","offLabel":[],"synonyms":["chloropyramine","chlorneoantergan","chloropyribenzamine","chlorpyramine","halopyramine","chloropyramine hydrochloride","chloropyramine HCl"],"timeline":[],"aiSummary":"Halopyramine (CHLOROPYRAMINE) is a small molecule drug that targets focal adhesion kinase 1. It belongs to the chloropyramine class and its mechanism of action is not well-documented. There is limited information available on its commercial status, approved indications, and pharmacokinetic properties. Further research is needed to understand its potential therapeutic applications and safety profile. As a result, it is not possible to provide a comprehensive summary of this compound.","approvals":[],"brandName":"Halopyramine","ecosystem":[],"mechanism":{"target":"Focal adhesion kinase 1","targets":[{"gene":"PTK2","source":"DrugCentral","target":"Focal adhesion kinase 1","protein":"Focal adhesion kinase 1"}],"modality":"Small Molecule","drugClass":"chloropyramine","explanation":"Think of focal adhesion kinase 1 like a messenger that helps cells stick together and communicate with each other. Halopyramine blocks this messenger, which can affect how cells behave and interact with their environment. This can potentially lead to changes in cell growth, movement, and other cellular processes.","oneSentence":"Halopyramine works by inhibiting focal adhesion kinase 1, a protein involved in cell signaling and adhesion.","technicalDetail":"Halopyramine is a small molecule inhibitor of focal adhesion kinase 1 (FAK1), a non-receptor tyrosine kinase involved in integrin-mediated signaling and cell adhesion. By binding to FAK1, halopyramine disrupts the kinase's activity, leading to changes in downstream signaling pathways and potentially affecting various cellular processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/606","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHLOROPYRAMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:33:34.638337","biosimilars":[],"competitors":[{"drugName":"mepyramine","drugSlug":"mepyramine","fdaApproval":"1973-08-07","relationship":"same-class"},{"drugName":"tripelennamine","drugSlug":"tripelennamine","fdaApproval":"1948-02-19","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"promethazine","drugSlug":"promethazine","fdaApproval":"1951-03-29","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clemastine","drugSlug":"clemastine","fdaApproval":"1977-02-25","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pheniramine","drugSlug":"pheniramine","fdaApproval":"1994-06-08","relationship":"same-class"},{"drugName":"diphenhydramine","drugSlug":"diphenhydramine","fdaApproval":"1946-03-04","genericCount":56,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"chloropyramine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"mepyramine","brandName":"mepyramine","genericName":"mepyramine","approvalYear":"1973","relationship":"same-class"},{"drugId":"tripelennamine","brandName":"tripelennamine","genericName":"tripelennamine","approvalYear":"1948","relationship":"same-class"},{"drugId":"promethazine","brandName":"promethazine","genericName":"promethazine","approvalYear":"1951","relationship":"same-class"},{"drugId":"clemastine","brandName":"clemastine","genericName":"clemastine","approvalYear":"1977","relationship":"same-class"},{"drugId":"pheniramine","brandName":"pheniramine","genericName":"pheniramine","approvalYear":"1994","relationship":"same-class"},{"drugId":"diphenhydramine","brandName":"diphenhydramine","genericName":"diphenhydramine","approvalYear":"1946","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"005999","UNII":"2K3L8O9SOV","CHEBI":"CHEBI:94767","INN_ID":"179","RXNORM":"20861","UMLSCUI":"C0055445","ChEMBL_ID":"CHEMBL1194287","KEGG_DRUG":"D07195","DRUGBANK_ID":"DB08800","PDB_CHEM_ID":"C4C","PUBCHEM_CID":"25295","SECONDARY_CAS_RN":"6170-42-9","MESH_SUPPLEMENTAL_RECORD_UI":"C004664"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":61,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"D04AA09","allCodes":["D04AA09","R06AC03","R06AC53"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Dec","pmid":"40760915","title":"Innovative strategies for cisplatin desensitization in hyperthermic intraperitoneal chemotherapy of ovarian cancer.","journal":"Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners"},{"date":"2025 Jan 6","pmid":"39760915","title":"Single-cell RNA-sequencing and genome-wide Mendelian randomisation along with abundant machine learning methods identify a novel B cells signature in gastric cancer.","journal":"Discover oncology"},{"date":"2024","pmid":"38904559","title":"[Oral sedation in pediatric outpatient dentistry].","journal":"Stomatologiia"},{"date":"2024 Apr","pmid":"38896318","title":"Suprastin (Chloropyramine) Causes Proarrhythmic Deterioration of Excitation Conduction, Depolarization and Potentiates Adrenergic Automaticity in the Pulmonary Veins Myocardium.","journal":"Bulletin of experimental biology and medicine"},{"date":"2023","pmid":"37113769","title":"pyHeart4Fish: Chamber-specific heart phenotype quantification of zebrafish in high-content screens.","journal":"Frontiers in cell and developmental biology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":false,"score":2}}