{"id":"chloroprocaine-1-injectable-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reactions (including anaphylaxis)"},{"rate":null,"effect":"Methemoglobinemia (with benzocaine-containing formulations; less common with chloroprocaine)"},{"rate":null,"effect":"Systemic toxicity (CNS and cardiovascular effects at high doses)"},{"rate":null,"effect":"Local tissue irritation or inflammation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an ester-type local anesthetic, chloroprocaine reversibly inhibits sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and action potential generation. This results in loss of sensation in the infiltrated tissue. Chloroprocaine is rapidly metabolized by plasma pseudocholinesterase, giving it a short duration of action compared to amide local anesthetics.","oneSentence":"Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:18:10.797Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local infiltration anesthesia for minor surgical procedures"},{"name":"Nerve blocks and regional anesthesia"}]},"trialDetails":[{"nctId":"NCT03918798","phase":"PHASE2","title":"The Efficacy and Safety of Chloroprocaine 1% and 2% in Pediatric Population","status":"COMPLETED","sponsor":"Sintetica SA","startDate":"2019-02-14","conditions":"Hernia, Inguinal, Flat Foot","enrollment":164},{"nctId":"NCT07456826","phase":"PHASE4","title":"Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections","status":"NOT_YET_RECRUITING","sponsor":"Harrow Inc","startDate":"2026-04","conditions":"Diabetic Macular Edema (DME), Age-Related Macular Degeneration (AMD), Retinal Vein Occlusion","enrollment":236},{"nctId":"NCT06376058","phase":"NA","title":"Chloroprocaine 1% Versus Ropivacaine 0,75% During Cesarean Section","status":"RECRUITING","sponsor":"Aretaieion University Hospital","startDate":"2024-01-10","conditions":"Cesarean Section, Local Anesthetic","enrollment":60},{"nctId":"NCT03967288","phase":"PHASE4","title":"Comparison of Clorotekal and Bupivacaine for Short Obstetric Surgery","status":"SUSPENDED","sponsor":"Oregon Health and Science University","startDate":"2019-10-24","conditions":"Anesthesia, Spinal","enrollment":27},{"nctId":"NCT03428230","phase":"PHASE2","title":"Intrathecal Paracetamol Before Spinal Anaesthesia With Chloroprocaine HCl 1% for Short Knee Procedures","status":"COMPLETED","sponsor":"Sintetica SA","startDate":"2018-08-06","conditions":"Pain, Postoperative","enrollment":60},{"nctId":"NCT02862912","phase":"PHASE4","title":"Chloroprocaine Spinal Anesthesia for Cervical Cerclage (CP Spinal)","status":"COMPLETED","sponsor":"Columbia University","startDate":"2016-11-08","conditions":"Adverse Reaction to Spinal Anesthetic, Maternal Care for Cervical Incompetence","enrollment":43},{"nctId":"NCT03805503","phase":"PHASE4","title":"Chloroprocaine for Inguinal Herniorrhaphy","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2015-09-16","conditions":"Spinal Anesthesia","enrollment":12}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ARM 1","chloroprocaine 3%"],"phase":"marketed","status":"active","brandName":"Chloroprocaine 1% Injectable Solution","genericName":"Chloroprocaine 1% Injectable Solution","companyName":"Sintetica SA","companyId":"sintetica-sa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chloroprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. Used for Local infiltration anesthesia for minor surgical procedures, Nerve blocks and regional anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}