{"id":"chlorogenic-acid-for-injection","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":{"chemblId":"CHEMBL284616","moleculeType":"Small molecule","molecularWeight":"354.31"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Chlorogenic acid is a polyphenolic compound that exerts cytoprotective effects through multiple mechanisms including free radical scavenging, inhibition of pro-inflammatory cytokine production, and modulation of oxidative stress. It has been investigated for its potential to reduce tissue damage and improve organ function in conditions characterized by oxidative stress and inflammation.","oneSentence":"Chlorogenic acid acts as an antioxidant and anti-inflammatory agent by scavenging free radicals and inhibiting inflammatory pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T03:26:39.597Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Liver injury and hepatoprotection (investigational)"},{"name":"Renal protection and kidney disease (investigational)"}]},"trialDetails":[{"nctId":"NCT03758014","phase":"PHASE2, PHASE3","title":"Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients","status":"UNKNOWN","sponsor":"Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd","startDate":"2018-11-27","conditions":"GBM","enrollment":200},{"nctId":"NCT03751592","phase":"PHASE1, PHASE2","title":"Phase Ib/IIa Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Advanced Lung Cancer","status":"UNKNOWN","sponsor":"Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd","startDate":"2018-07-17","conditions":"Advanced Lung Cancer","enrollment":144},{"nctId":"NCT02245204","phase":"PHASE1","title":"Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers","status":"COMPLETED","sponsor":"Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd","startDate":"2014-09","conditions":"Advanced Cancer","enrollment":8},{"nctId":"NCT02728349","phase":"PHASE1","title":"Tolerance and Pharmacokinetic Study of Chlorogenic Acid to Advanced Glioblastoma","status":"COMPLETED","sponsor":"Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd","startDate":"2016-04-12","conditions":"Glioblastoma","enrollment":26},{"nctId":"NCT02136342","phase":"PHASE1","title":"Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer","status":"TERMINATED","sponsor":"Chinese Academy of Medical Sciences","startDate":"2014-05","conditions":"Advanced Cancer","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CHA"],"phase":"phase_2","status":"active","brandName":"Chlorogenic acid for Injection","genericName":"Chlorogenic acid for Injection","companyName":"Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd","companyId":"sichuan-j-z-bio-chemical-science-and-technology-development-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorogenic acid acts as an antioxidant and anti-inflammatory agent by scavenging free radicals and inhibiting inflammatory pathways. Used for Liver injury and hepatoprotection (investigational), Renal protection and kidney disease (investigational).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}