{"id":"chlormadinone","rwe":[{"pmid":"41732194","year":"2026","title":"Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysis.","finding":"","journal":"EClinicalMedicine","studyType":"Clinical Study"},{"pmid":"41723577","year":"2026","title":"Comparison of Substances in Combined Oral Contraceptives Used in Acne Vulgaris, Hirsutism, Migraine, and Dysmenorrhea.","finding":"","journal":"Medical science monitor : international medical journal of experimental and clinical research","studyType":"Clinical Study"},{"pmid":"41067517","year":"2026","title":"Risk of venous thromboembolism associated with chlormadinone acetate- and levonorgestrel-containing combined oral contraceptives - Insights from the retrospective RIVET-RCS study.","finding":"","journal":"Contraception","studyType":"Clinical Study"},{"pmid":"40353175","year":"2025","title":"Paradoxical evolution of spheno-orbital meningioma after cessation of progestin treatment.","finding":"","journal":"Surgical neurology international","studyType":"Clinical Study"},{"pmid":"39820188","year":"2025","title":"Investigating dosage effects of ovulation inhibitors on oocyte maturation in assisted reproductive technology: A retrospective study among patients with normal ovarian reserve.","finding":"","journal":"PloS one","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Glucocorticoid receptor","category":"target"},{"label":"NR3C1","category":"gene"},{"label":"CYP2C19","category":"gene"},{"label":"G03AA15","category":"atc"},{"label":"Active","category":"status"},{"label":"Endometriosis","category":"indication"},{"label":"Menorrhagia","category":"indication"},{"label":"Androgen Antagonists","category":"pharmacology"},{"label":"Contraceptive Agents","category":"pharmacology"},{"label":"Contraceptive Agents, Female","category":"pharmacology"},{"label":"Contraceptive Agents, Hormonal","category":"pharmacology"},{"label":"Contraceptives, Oral, Hormonal","category":"pharmacology"},{"label":"Contraceptives, Oral, Synthetic","category":"pharmacology"},{"label":"Hormone Antagonists","category":"pharmacology"},{"label":"Reproductive Control Agents","category":"pharmacology"}],"phase":"unknown","safety":{"safetySignals":[{"llr":138.654,"date":"","count":26,"signal":"Meningioma","source":"DrugCentral FAERS","actionTaken":"Reported 26 times (LLR=139)"},{"llr":98.736,"date":"","count":10,"signal":"Ulnar tunnel syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=99)"},{"llr":59.372,"date":"","count":12,"signal":"Diabetic metabolic decompensation","source":"DrugCentral FAERS","actionTaken":"Reported 12 times (LLR=59)"}],"commonSideEffects":[{"effect":"Meningioma","drugRate":"LLR 139","severity":"common"},{"effect":"Ulnar tunnel syndrome","drugRate":"LLR 99","severity":"common"},{"effect":"Diabetic metabolic decompensation","drugRate":"LLR 59","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"menstridyl","offLabel":[],"synonyms":["chlormadinone","chlormadinone acetate","chlormadinon","chlormadinon acetate","menstridyl"],"timeline":[],"approvals":[],"brandName":"Menstridyl","ecosystem":[{"indication":"Endometriosis","otherDrugs":[{"name":"danazol","slug":"danazol","company":""},{"name":"elagolix","slug":"elagolix","company":"Abbvie Inc "},{"name":"goserelin","slug":"goserelin","company":"Astrazeneca"},{"name":"leuprorelin","slug":"leuprorelin","company":""}],"globalPrevalence":null},{"indication":"Menorrhagia","otherDrugs":[{"name":"levonorgestrel","slug":"levonorgestrel","company":"Wyeth Pharms"},{"name":"meclofenamic acid","slug":"meclofenamic-acid","company":""},{"name":"mestranol","slug":"mestranol","company":""},{"name":"norethisterone","slug":"norethisterone","company":"Ortho Mcneil Pharm"}],"globalPrevalence":null}],"mechanism":{"target":"Glucocorticoid receptor","targets":[{"gene":"NR3C1","source":"DrugCentral","target":"Glucocorticoid receptor","protein":"Glucocorticoid receptor"},{"gene":"CYP2C19","source":"DrugCentral","target":"Cytochrome P450 2C19","protein":"Cytochrome P450 2C19"}],"modality":"Small Molecule","explanation":"Think of cortisol like a key that unlocks certain processes in the body. Menstridyl is like a lock that blocks that key, preventing cortisol from triggering certain responses in the body. This can help reduce symptoms like heavy bleeding and pain associated with endometriosis and menorrhagia.","oneSentence":"Menstridyl works by blocking the action of cortisol, a hormone involved in the menstrual cycle.","technicalDetail":"Menstridyl (chlormadinone) is a synthetic steroid that acts as a competitive antagonist at the glucocorticoid receptor, inhibiting the transcriptional activity of glucocorticoid-induced genes and thereby exerting its therapeutic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/600","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=chlormadinone","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=chlormadinone","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:34:21.526391","biosimilars":[],"competitors":[{"drugName":"ethinylestradiol","drugSlug":"ethinylestradiol","fdaApproval":"1943-06-25","relationship":"same-class"},{"drugName":"etynodiol","drugSlug":"etynodiol","fdaApproval":"1966-03-23","relationship":"same-class"},{"drugName":"megestrol acetate","drugSlug":"megestrol-acetate","fdaApproval":"1971-08-18","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"norethisterone","drugSlug":"norethisterone","fdaApproval":"1962-05-21","relationship":"same-class"},{"drugName":"levonorgestrel","drugSlug":"levonorgestrel","fdaApproval":"1968-04-16","patentExpiry":"Sep 7, 2040","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"medroxyprogesterone","drugSlug":"medroxyprogesterone","fdaApproval":"1959-06-18","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"desogestrel","drugSlug":"desogestrel","fdaApproval":"1992-12-10","relationship":"same-class"},{"drugName":"norgestimate","drugSlug":"norgestimate","fdaApproval":"1989-12-29","relationship":"same-class"},{"drugName":"drospirenone","drugSlug":"drospirenone","fdaApproval":"2019-05-23","patentExpiry":"Jun 28, 2031","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"chlormadinone","indications":{"approved":[{"name":"Endometriosis","source":"DrugCentral","snomedId":129103003,"regulator":"FDA"},{"name":"Menorrhagia","source":"DrugCentral","snomedId":386692008,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"ethinylestradiol","brandName":"ethinylestradiol","genericName":"ethinylestradiol","approvalYear":"1943","relationship":"same-class"},{"drugId":"etynodiol","brandName":"etynodiol","genericName":"etynodiol","approvalYear":"1966","relationship":"same-class"},{"drugId":"megestrol-acetate","brandName":"megestrol acetate","genericName":"megestrol acetate","approvalYear":"1971","relationship":"same-class"},{"drugId":"norethisterone","brandName":"norethisterone","genericName":"norethisterone","approvalYear":"1962","relationship":"same-class"},{"drugId":"levonorgestrel","brandName":"levonorgestrel","genericName":"levonorgestrel","approvalYear":"1968","relationship":"same-class"},{"drugId":"medroxyprogesterone","brandName":"medroxyprogesterone","genericName":"medroxyprogesterone","approvalYear":"1959","relationship":"same-class"},{"drugId":"desogestrel","brandName":"desogestrel","genericName":"desogestrel","approvalYear":"1992","relationship":"same-class"},{"drugId":"norgestimate","brandName":"norgestimate","genericName":"norgestimate","approvalYear":"1989","relationship":"same-class"},{"drugId":"drospirenone","brandName":"drospirenone","genericName":"drospirenone","approvalYear":"2019","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02828904","phase":"","title":"RIVET - Retrospective Cohort Study on the Risk of Venous Thromboembolism","status":"COMPLETED","sponsor":"Center for Epidemiology and Health Research, Germany","startDate":"2022-03-10","conditions":["Venous Thromboembolism"],"enrollment":124000,"completionDate":"2024-01-31"},{"nctId":"NCT01608698","phase":"PHASE4","title":"Comparison of Body Weight Change During Contraception With Belara and Yasmin","status":"UNKNOWN","sponsor":"Mahidol University","startDate":"2012-06","conditions":["Body Weight Changes"],"enrollment":100,"completionDate":"2016-02"},{"nctId":"NCT01123538","phase":"PHASE4","title":"Progestagen Type in Postmenopausal Hormone Therapy and Blood Gene Expression Profile","status":"UNKNOWN","sponsor":"University Hospital of North Norway","startDate":"2008-12","conditions":["Pharmacogenomics","Systems Biology"],"enrollment":40,"completionDate":"2012-10"},{"nctId":"NCT00842140","phase":"NA","title":"Safety of Hormonal Contraceptives Therapies in Polycystic Ovary Syndrome (PCOS) Women","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2006-02","conditions":["Polycystic Ovary Syndrome"],"enrollment":75,"completionDate":"2009-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001294","UNII":"SDS4N642GG","CHEBI":"CHEBI:31394","INN_ID":"1210","RXNORM":"2369","UMLSCUI":"C0008214","ChEMBL_ID":"CHEMBL110691","KEGG_DRUG":"D01299","DRUGBANK_ID":"DB13528","PUBCHEM_CID":"5284533","SNOMEDCT_US":"734645001","SECONDARY_CAS_RN":"1961-77-9","MESH_DESCRIPTOR_UI":"D002715"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":936,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"G03AA15","allCodes":["G03AA15","G03AB07","G03DB06","G03FB03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb","pmid":"41732194","title":"Progestogen use and the risk of intracranial meningioma: a systematic review and meta-analysis.","journal":"EClinicalMedicine"},{"date":"2026 Feb 22","pmid":"41723577","title":"Comparison of Substances in Combined Oral Contraceptives Used in Acne Vulgaris, Hirsutism, Migraine, and Dysmenorrhea.","journal":"Medical science monitor : international medical journal of experimental and clinical research"},{"date":"2026 Jan","pmid":"41067517","title":"Risk of venous thromboembolism associated with chlormadinone acetate- and levonorgestrel-containing combined oral contraceptives - Insights from the retrospective RIVET-RCS study.","journal":"Contraception"},{"date":"2025","pmid":"40353175","title":"Paradoxical evolution of spheno-orbital meningioma after cessation of progestin treatment.","journal":"Surgical neurology international"},{"date":"2025","pmid":"39820188","title":"Investigating dosage effects of ovulation inhibitors on oocyte maturation in assisted reproductive technology: A retrospective study among patients with normal ovarian reserve.","journal":"PloS one"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Menstridyl (chlormadinone) is a small molecule modality targeting the glucocorticoid receptor. It is used to treat endometriosis and menorrhagia, but its commercial status and FDA approval status are unknown. As a glucocorticoid receptor antagonist, Menstridyl works by blocking the action of cortisol, a hormone involved in the regulation of the menstrual cycle. This can help reduce symptoms associated with endometriosis and menorrhagia. However, more information is needed to fully understand its pharmacological properties and clinical applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}