{"id":"chlorhexidine-thymol-varnish","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral irritation or staining"},{"rate":null,"effect":"Taste disturbance"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine is a broad-spectrum antimicrobial that disrupts bacterial cell membranes and inhibits bacterial metabolism, while thymol is a natural phenolic compound with antimicrobial and antifungal properties. When combined in a varnish formulation, they provide sustained local delivery to oral tissues for prevention and treatment of oral infections, plaque, and fungal conditions.","oneSentence":"Chlorhexidine and thymol work together as antimicrobial and antifungal agents in a varnish formulation applied topically to oral tissues.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:40:21.713Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral antimicrobial prophylaxis and treatment"},{"name":"Candidiasis prevention and treatment"},{"name":"Plaque and gingivitis management"}]},"trialDetails":[{"nctId":"NCT06331442","phase":"NA","title":"The Effect of Photodynamic Therapy on Plaque in Orthodontic Patients","status":"NOT_YET_RECRUITING","sponsor":"University of Zagreb","startDate":"2024-05","conditions":"Plaque, Dental, Dental Plaque Induced Gingivitis, White Spot Lesion","enrollment":50},{"nctId":"NCT02202304","phase":"PHASE4","title":"The Effects of Chlorhexidine/Thymol Varnish on Partial Denture Patient","status":"WITHDRAWN","sponsor":"Rosa Moreno Lopez","startDate":"2017-09-10","conditions":"Periodontal Disease, Caries","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cervitec Plus (1% chlorhexidine plus 1% thymol)"],"phase":"marketed","status":"active","brandName":"Chlorhexidine/Thymol varnish","genericName":"Chlorhexidine/Thymol varnish","companyName":"Rosa Moreno Lopez","companyId":"rosa-moreno-lopez","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine and thymol work together as antimicrobial and antifungal agents in a varnish formulation applied topically to oral tissues. Used for Oral antimicrobial prophylaxis and treatment, Candidiasis prevention and treatment, Plaque and gingivitis management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}