{"id":"chlorhexidine","rwe":[{"pmid":"41905896","year":"2026","title":"Dental Biofilm-Induced Gingivitis in Children and Adolescents Without Known Systemic Involvement: A Systematic Review.","finding":"","journal":"Journal of clinical periodontology","studyType":"Clinical Study"},{"pmid":"41901644","year":"2026","title":"In Vitro Efficacy of Ultrasonic Debridement with Adjunctive St. John's Wort on Multispecies Dental Biofilms.","finding":"","journal":"Medicina (Kaunas, Lithuania)","studyType":"Clinical Study"},{"pmid":"41899900","year":"2026","title":"Comparative Evaluation of Beverage-Induced Surface Alterations on Dental Enamel: An In Vitro Biomaterial Study.","finding":"","journal":"Bioengineering (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41897129","year":"2026","title":"Effects of Boric Acid and Chlorhexidine as Cavity Disinfectants on Microleakage and Microshear Bond Strength in Primary Teeth.","finding":"","journal":"Children (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41895341","year":"2026","title":"Evaluation of preventive interventions addressing Healthcare-Associated Infections and Antimicrobial Resistance: A Systematic Review.","finding":"","journal":"The Journal of hospital infection","studyType":"Clinical Study"}],"_fda":{"id":"f0b7b337-be39-2e5f-e053-2995a90a3c8c","set_id":"014a5f36-0396-498b-901f-9a86df4e11fe","openfda":{"upc":["0361037414070","0361037414087","0361037414063","0361037414032","0361037414049","0361037414025"],"unii":["MOR84MUD8E"],"route":["TOPICAL"],"spl_id":["f0b7b337-be39-2e5f-e053-2995a90a3c8c"],"brand_name":["Chlorhexidine Gluconate Solution 0.75% Antiseptic"],"spl_set_id":["014a5f36-0396-498b-901f-9a86df4e11fe"],"package_ndc":["61037-414-01","61037-414-02","61037-414-05","61037-414-06","61037-414-07","61037-414-03","61037-414-04","61037-414-08"],"product_ndc":["61037-414"],"generic_name":["CHLORHEXIDINE GLUCONATE SOLUTION 0.75% ANTISEPTIC"],"product_type":["HUMAN OTC DRUG"],"substance_name":["CHLORHEXIDINE GLUCONATE"],"manufacturer_name":["Bajaj Medical, LLC"],"application_number":["NDA020111"],"is_original_packager":[true]},"purpose":["Purpose Antiseptic"],"version":"15","stop_use":["Stop use and ask a doctor if irritation, sensitization, or allergic reaction occurs. These may be signs of a serious condition."],"warnings":["Warnings For external use only Allergy alert: This product may cause a severe allergic reaction. Symptoms may include: wheezing/difficulty breathing shock facial swelling hives rash If an allergic reaction occurs, stop use and seek medical help right away. Do not use if you are allergic to chlorhexidine gluconate or any other ingredient in this product When using this product keep out of eyes, ears, and mouth. May cause serious and permanent eye injury if permitted to enter and remain in the eye or may cause deafness when instilled in the middle ear through perforated eardrums. if solution should contact these areas, rinse out promptly and thoroughly with water do not use routinely if you have wounds which involve more than the superficial layers of the skin Stop use and ask a doctor if irritation, sensitization, or allergic reaction occurs. These may be signs of a serious condition. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"questions":["Questions or comments? call 1-800-581-2528 , 24 hours a day, 7 days a week"],"do_not_use":["Do not use if you are allergic to chlorhexidine gluconate or any other ingredient in this product"],"when_using":["When using this product keep out of eyes, ears, and mouth. May cause serious and permanent eye injury if permitted to enter and remain in the eye or may cause deafness when instilled in the middle ear through perforated eardrums. if solution should contact these areas, rinse out promptly and thoroughly with water do not use routinely if you have wounds which involve more than the superficial layers of the skin"],"effective_time":"20221226","active_ingredient":["Active ingredient Chlorhexidine gluconate solution, 0.75%"],"inactive_ingredient":["Inactive ingredients citric acid, cocamide DEA, FD&C yellow #5, FD&C red #4, fragrance, hydroxyethylcellulose, isopropyl alcohol, lauramine oxide, purified water, ricinoleamidopropyl trimethyl ammonium chloride"],"storage_and_handling":["Other information store at 20-25°C (68-77°F) avoid excessive heat above 40°C (104°F)","Keep from freezing."],"indications_and_usage":["Use healthcare personnel handwash: helps reduce bacteria that potentially can cause disease"],"dosage_and_administration":["Directions use with care in premature infants and infants under 2 months of age. These products may cause irritation or chemical burns. Healthcare personnel handwash: wet hands with water dispense about 5 mL of product into cupped hands and wash in a vigorous manner for 30 seconds rinse and dry thoroughly","Healthcare personnel handwash: wet hands with water dispense about 5 mL of product into cupped hands and wash in a vigorous manner for 30 seconds rinse and dry thoroughly"],"spl_product_data_elements":["Chlorhexidine Gluconate Solution 0.75% Antiseptic Chlorhexidine Gluconate Solution 0.75% Antiseptic COCO DIETHANOLAMIDE HYDROXYETHYL CELLULOSE (140 CPS AT 5%) ISOPROPYL ALCOHOL LAURAMINE OXIDE RICINOLEAMIDOPROPYLTRIMONIUM CHLORIDE WATER CITRIC ACID MONOHYDRATE FD&C YELLOW NO. 5 FD&C RED NO. 4 CHLORHEXIDINE GLUCONATE CHLORHEXIDINE"],"keep_out_of_reach_of_children":["Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away."],"package_label_principal_display_panel":["Package/Label Principal Display Panel Chlorhexidine Gluconate Solution 0.75% ANTISEPTIC FOR EXTERNAL USE ONLY Bajaj Medical Chicago IL 60609 4 fl oz (118 mL) NDC 61037-414-01 MADE IN THE USA FDA APPROVED Chlorhexidine Gluconate Solution 0.75% ANTISEPTIC FOR EXTERNAL USE ONLY Bajaj Medical Chicago IL 60609 8 fl oz (236 mL) NDC 61037-414-02 MADE IN THE USA FDA APPROVED Chlorhexidine Gluconate Solution 0.75% ANTISEPTIC FOR EXTERNAL USE ONLY Bajaj Medical Chicago IL 60609 16 fl oz (473 mL) NDC 61037-414-05 MADE IN THE USA FDA APPROVED Chlorhexidine Gluconate Solution 0.75% ANTISEPTIC FOR EXTERNAL USE ONLY Bajaj Medical Chicago IL 60609 32 fl oz (946 mL) NDC 61037-414-06 MADE IN THE USA FDA APPROVED Chlorhexidine Gluconate Solution 0.75% ANTISEPTIC FOR EXTERNAL USE ONLY Bajaj Medical Chicago IL 60609 128 fl oz (3785 mL) NDC 61037-414-07 MADE IN THE USA FDA APPROVED Chlorhexidine Gluconate Solution 0.75% ANTISEPTIC FOR EXTERNAL USE ONLY Bajaj Medical Chicago IL 60609 8 fl oz (236 mL) NDC 61037-414-03 MADE IN THE USA FDA APPROVED Chlorhexidine Gluconate Solution 0.75% ANTISEPTIC FOR EXTERNAL USE ONLY Bajaj Medical Chicago IL 60609 8 fl oz (236 mL) NDC 61037-414-04 MADE IN THE USA FDA APPROVED Chlorhexidine Gluconate Solution 0.75% ANTISEPTIC FOR EXTERNAL USE ONLY Bajaj Medical Chicago IL 60609 40.6 fl oz (1.2 L) NDC 61037-414-08 MADE IN THE USA FDA APPROVED 4ozlbl 8ozlbl 16ozlbl 32ozlbl 128ozlbl 8ozlblclr 8ozlblwht 1200mllbl Keep from freezing."]},"tags":[{"label":"chlorhexidine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Solute carrier family 22 member 1","category":"target"},{"label":"SLC22A1","category":"gene"},{"label":"SLC22A2","category":"gene"},{"label":"SLC22A3","category":"gene"},{"label":"A01AB03","category":"atc"},{"label":"Irrigation","category":"route"},{"label":"Topical","category":"route"},{"label":"Extracorporeal","category":"route"},{"label":"Cloth","category":"form"},{"label":"Concentrate","category":"form"},{"label":"Gel","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Established","category":"status"},{"label":"Gingivitis","category":"indication"},{"label":"Mouth Infection Prevention","category":"indication"},{"label":"Molnlycke Hlth","category":"company"},{"label":"Approved 1970s","category":"decade"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Infective Agents, Local","category":"pharmacology"},{"label":"Cosmetics","category":"pharmacology"},{"label":"Dermatologic Agents","category":"pharmacology"},{"label":"Disinfectants","category":"pharmacology"},{"label":"Mouthwashes","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"llr":5735.419,"date":"","count":4105,"signal":"Completed suicide","source":"DrugCentral FAERS","actionTaken":"Reported 4,105 times (LLR=5735)"},{"llr":4716.735,"date":"","count":3174,"signal":"Drug abuse","source":"DrugCentral FAERS","actionTaken":"Reported 3,174 times (LLR=4717)"},{"llr":3585.009,"date":"","count":4208,"signal":"Toxicity to various agents","source":"DrugCentral FAERS","actionTaken":"Reported 4,208 times (LLR=3585)"},{"llr":2912.499,"date":"","count":1728,"signal":"Muscle injury","source":"DrugCentral FAERS","actionTaken":"Reported 1,728 times (LLR=2912)"},{"llr":2908.423,"date":"","count":1801,"signal":"Folliculitis","source":"DrugCentral FAERS","actionTaken":"Reported 1,801 times (LLR=2908)"},{"llr":2717.996,"date":"","count":1809,"signal":"Irritable bowel syndrome","source":"DrugCentral FAERS","actionTaken":"Reported 1,809 times (LLR=2718)"},{"llr":2376.519,"date":"","count":2140,"signal":"Lower respiratory tract infection","source":"DrugCentral FAERS","actionTaken":"Reported 2,140 times (LLR=2377)"},{"llr":2250.088,"date":"","count":1806,"signal":"Impaired healing","source":"DrugCentral FAERS","actionTaken":"Reported 1,806 times (LLR=2250)"},{"llr":2182.163,"date":"","count":1332,"signal":"Sleep disorder due to general medical condition, insomnia type","source":"DrugCentral FAERS","actionTaken":"Reported 1,332 times (LLR=2182)"},{"llr":1963.157,"date":"","count":1859,"signal":"Blister","source":"DrugCentral FAERS","actionTaken":"Reported 1,859 times (LLR=1963)"},{"llr":1633.616,"date":"","count":1414,"signal":"Ill-defined disorder","source":"DrugCentral FAERS","actionTaken":"Reported 1,414 times (LLR=1634)"},{"llr":1628.479,"date":"","count":1820,"signal":"Stomatitis","source":"DrugCentral FAERS","actionTaken":"Reported 1,820 times (LLR=1628)"},{"llr":1522.332,"date":"","count":1702,"signal":"Gastrointestinal disorder","source":"DrugCentral FAERS","actionTaken":"Reported 1,702 times (LLR=1522)"},{"llr":1422.482,"date":"","count":1258,"signal":"Duodenal ulcer perforation","source":"DrugCentral FAERS","actionTaken":"Reported 1,258 times (LLR=1422)"},{"llr":1408.555,"date":"","count":1289,"signal":"Helicobacter infection","source":"DrugCentral FAERS","actionTaken":"Reported 1,289 times (LLR=1409)"}],"commonSideEffects":[],"contraindications":["Front Tooth Fillings","Open wound","Periodontitis"],"specialPopulations":{"Pregnancy":"Pregnancy Category B. Reproduction Studies have been performed in rats and rabbits at chlorhexidine gluconate doses up to 300 mg/kg/day and 40 mg/kg/day respectively, and have not revealed evidence of harm to fetus. However, adequate and well-controlled studies in pregnant women have not been done. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.","Geriatric use":"Although subjects aged 65 years and over were included in clinical studies of PerioChip, there were not sufficient numbers of these subjects to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Overall differences in safety or effectiveness have not been identified between the elderly and younger patients.","Paediatric use":"Clinical effectiveness and safety of chlorhexidine gluconate oral rinse have not been established in children under the age of 18."}},"trials":[],"aliases":[],"company":"Molnlycke Hlth","patents":[],"pricing":[{"market":"United States","source":"CMS National Average Drug Acquisition Cost (NADAC)","asOfDate":"2024-01-03","unitCost":"$0.0054/ML","priceType":"NADAC","sourceUrl":"https://data.medicaid.gov/dataset/4j6z-xnwq","annualCost":"$2","description":"CHLORHEXIDINE 0.12% RINSE","retrievedDate":"2026-04-07"}],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CHLORHEXIDINE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T06:06:54.001167+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T06:07:26.351802+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHLORHEXIDINE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T06:07:09.405254+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T06:06:52.893265+00:00"},"indications.approved":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"fda_label","retrievedAt":"2026-04-20T06:07:17.103130+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T06:06:52.893303+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1628/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T06:07:10.118370+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"NDA020111","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T06:06:52.893308+00:00"}},"allNames":"exidine","offLabel":[],"synonyms":["chlorhexidine hydrochloride","chlorhexidine","chlorohex","chlorohexidine","chlorhexidine gluconate","chlorhexidine acetate"],"timeline":[{"date":"1976-01-01","type":"neutral","source":"FDA Orange Book","milestone":"Rights transferred from MOLNLYCKE HLTH to Molnlycke Hlth"},{"date":"1976-09-17","type":"positive","source":"DrugCentral","milestone":"FDA approval (Molnlycke Hlth)"},{"date":"1984-12-24","type":"positive","source":"FDA Orange Book","milestone":"Exidine approved — 4%"},{"date":"1985-12-17","type":"positive","source":"FDA Orange Book","milestone":"Dyna-Hex 2 approved — 2%"},{"date":"1986-07-22","type":"positive","source":"FDA Orange Book","milestone":"Chg Scrub approved — 4%"},{"date":"1986-08-13","type":"positive","source":"FDA Orange Book","milestone":"Peridex approved — 0.12%"},{"date":"1987-03-27","type":"positive","source":"FDA Orange Book","milestone":"Chlorhexidine Gluconate approved — 4%"},{"date":"1988-12-02","type":"positive","source":"FDA Orange Book","milestone":"Pharmaseal Scrub Care approved — 4%"},{"date":"1989-03-31","type":"positive","source":"FDA Orange Book","milestone":"Bioscrub approved — 4%"},{"date":"1991-04-15","type":"neutral","source":"FDA Orange Book","milestone":"Generic entry — 4 manufacturers approved"},{"date":"1997-09-11","type":"positive","source":"FDA Orange Book","milestone":"Chlorhexidine Gluconate approved — 0.75%"},{"date":"1998-05-15","type":"positive","source":"FDA Orange Book","milestone":"Periochip approved — 2.5MG"},{"date":"2005-04-25","type":"positive","source":"FDA Orange Book","milestone":"Chlorhexidine Gluconate approved — 2%"},{"date":"2018-11-20","type":"positive","source":"FDA Orange Book","milestone":"Readyprep Chg approved — 2%"}],"aiSummary":"Chlorhexidine (Exidine), marketed by Molnlycke Health, is a leading antiseptic solution primarily used for healthcare personnel hand hygiene. Its key strength lies in its mechanism of action, which effectively disrupts bacterial cell membranes, leading to cell death, providing robust protection against a wide range of pathogens. The primary risk is the upcoming key composition patent expiry in 2028, which could lead to increased competition from generics and other antiseptics in the same class, such as hydrogen peroxide and neomycin.","approvals":[{"date":"1976-09-17","orphan":false,"company":"MOLNLYCKE HLTH","regulator":"FDA"}],"brandName":"Exidine","ecosystem":[{"indication":"Gingivitis","otherDrugs":[],"globalPrevalence":null},{"indication":"Mouth Infection Prevention","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Solute carrier family 22 member 1","novelty":"Follow-on","targets":[{"gene":"SLC22A1","source":"DrugCentral","target":"Solute carrier family 22 member 1","protein":"Solute carrier family 22 member 1"},{"gene":"SLC22A2","source":"DrugCentral","target":"Solute carrier family 22 member 2","protein":"Solute carrier family 22 member 2"},{"gene":"SLC22A3","source":"DrugCentral","target":"Solute carrier family 22 member 3","protein":"Solute carrier family 22 member 3"},{"gene":"SLC47A2","source":"DrugCentral","target":"Multidrug and toxin extrusion protein 2","protein":"Multidrug and toxin extrusion protein 2"},{"gene":"SLC47A1","source":"DrugCentral","target":"Multidrug and toxin extrusion protein 1","protein":"Multidrug and toxin extrusion protein 1"},{"gene":"MMP2","source":"DrugCentral","target":"72 kDa type IV collagenase","protein":"72 kDa type IV collagenase"},{"gene":"MMP9","source":"DrugCentral","target":"Matrix metalloproteinase-9","protein":"Matrix metalloproteinase-9"},{"gene":"SYNJ2","source":"DrugCentral","target":"Synaptojanin-2","protein":"Synaptojanin-2"}],"modality":"Small Molecule","drugClass":"chlorhexidine","explanation":"","oneSentence":"","technicalDetail":"Exidine binds to the bacterial cell membrane through ionic interactions, disrupting the membrane's integrity and leading to cell lysis and death."},"commercial":{"launchDate":"1976","_launchSource":"DrugCentral (FDA 1976-09-17, MOLNLYCKE HLTH)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/597","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CHLORHEXIDINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHLORHEXIDINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T09:34:10.461687","_validation":{"fieldsValidated":2,"lastValidatedAt":"2026-04-20T06:07:26.351916+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"hydrogen peroxide","drugSlug":"hydrogen-peroxide","fdaApproval":"","patentExpiry":"Jul 4, 2035","patentStatus":"Patent 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available","relationship":"same-class"},{"drugName":"metronidazole","drugSlug":"metronidazole","fdaApproval":"1963-07-18","patentExpiry":"Oct 4, 2039","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"clotrimazole","drugSlug":"clotrimazole","fdaApproval":"1975-02-03","patentExpiry":"May 26, 2042","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlortetracycline","drugSlug":"chlortetracycline","fdaApproval":"1950-01-23","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"doxycycline","drugSlug":"doxycycline","fdaApproval":"1967-12-05","patentExpiry":"Dec 19, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"minocycline","drugSlug":"minocycline","fdaApproval":"1971-06-30","patentExpiry":"Sep 8, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"oxytetracycline","drugSlug":"oxytetracycline","fdaApproval":"1964-09-08","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://data.medicaid.gov/dataset/4j6z-xnwq","name":"CMS National Average Drug Acquisition Cost (NADAC)","fields":["pricing"],"retrievedDate":"2026-04-07"}],"genericName":"chlorhexidine","indications":{"approved":[{"id":"chlorhexidine-healthcare-personnel-hand-hygi","name":"Healthcare personnel hand hygiene","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Healthcare personnel","pivotalTrial":null,"restrictions":[],"patientPopulation":"Healthcare personnel","diagnosticRequired":null,"brandNameForIndication":"Exidine"}],"offLabel":[{"name":"Aphthous ulcer of mouth","source":"DrugCentral","drugName":"CHLORHEXIDINE","evidenceCount":34,"evidenceLevel":"moderate"},{"name":"Dental Plaque Prevention","source":"DrugCentral","drugName":"CHLORHEXIDINE","evidenceCount":1328,"evidenceLevel":"strong"},{"name":"Denture stomatitis","source":"DrugCentral","drugName":"CHLORHEXIDINE","evidenceCount":99,"evidenceLevel":"strong"}],"pipeline":[]},"currentOwner":"Molnlycke Hlth","drugCategory":"established","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"hydrogen-peroxide","brandName":"hydrogen peroxide","genericName":"hydrogen peroxide","approvalYear":"","relationship":"same-class"},{"drugId":"amphotericin-b","brandName":"amphotericin B","genericName":"amphotericin 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Restoration of a New Implant With High Primary Stability","status":"NOT_YET_RECRUITING","sponsor":"Universidade do Porto","startDate":"2026-03-01","conditions":["Dental Implants","Immediate Dental Implant Loading"],"enrollment":50,"completionDate":"2027-12-30"},{"nctId":"NCT07321704","phase":"NA","title":"Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease","status":"RECRUITING","sponsor":"Yosef Nasseri, MD","startDate":"2026-02-17","conditions":["Pilonidal Disease"],"enrollment":60,"completionDate":"2027-12-01"},{"nctId":"NCT05312606","phase":"NA","title":"Hyaluronic Gel vs Chlorhexidine in Periodontal Patients","status":"COMPLETED","sponsor":"University of Pavia","startDate":"2022-04-04","conditions":["Periodontal Diseases"],"enrollment":40,"completionDate":"2022-11-05"},{"nctId":"NCT07416136","phase":"NA","title":"The Aim of This Study is to Compare the Effects of Two Different Topical Agents (KLOROBEN® and KLORHEX PLUS®) Used in the Surgical Extraction of Mandibular Bilateral Mesioangular Impacted Third Molars on Postoperative Pain, Edema, and Trismus.","status":"COMPLETED","sponsor":"Marmara University","startDate":"2025-04-20","conditions":["Impacted Mandibular Third Molar"],"enrollment":40,"completionDate":"2025-10-19"},{"nctId":"NCT07311512","phase":"NA","title":"PMPR and Chlorhexidine on Periodontal Disease and Vascular Function","status":"RECRUITING","sponsor":"Mahdi Mutahar","startDate":"2026-01-23","conditions":["Periodontal Disease (PD)","Cardio Vascular Disease","Oral-Systemic Link","Vascular Dysfunction","Endothelial Function and Arterial Stiffness"],"enrollment":30,"completionDate":"2028-07-01"},{"nctId":"NCT07490873","phase":"NA","title":"Antiplaque Efficacy and Patient Reported Outcome of Chlorohexidine, Cetylpyridinium Chloride, and Essential Oil Mouthwashes in Orthodontic Patients","status":"RECRUITING","sponsor":"University of 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