{"id":"chlorbetamide","rwe":[{"pmid":"13698989","year":"1961","title":"Treatment of hookworm with chlorbetamide, bephenium and tetrachlorethylene.","finding":"","journal":"The Journal of tropical medicine and hygiene","studyType":"Clinical Study"},{"pmid":"13690328","year":"1960","title":"[Comparative study of the activity of chlorophenoxamide and chlorbetamide on Brazilian strains of Endamoeba histolytica and Endamoeba moshkovskii].","finding":"","journal":"Revista brasileira de gastroenterologia","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"mantomide","offLabel":[],"synonyms":["chlorbetamide","clorbetamida","mantomide"],"timeline":[],"approvals":[],"brandName":"Mantomide","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your brain is a city with many different streets and intersections. Mantomide helps to improve communication between the different areas of the city by increasing the activity of chemical messengers, called neurotransmitters, that carry signals between the streets.","oneSentence":"Mantomide works by enhancing the activity of neurotransmitters in the brain.","technicalDetail":"Mantomide is a GABA receptor agonist, which means it binds to and activates GABA receptors in the brain, leading to an increase in inhibitory neurotransmission and a decrease in neuronal excitability."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/592","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHLORBETAMIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:33:19.007885","biosimilars":[],"competitors":[],"genericName":"chlorbetamide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"3S489RFX0J","CHEBI":"CHEBI:135412","INN_ID":"360","UMLSCUI":"C2699182","ChEMBL_ID":"CHEMBL2106082","PUBCHEM_CID":"7330"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"1961 Jul","pmid":"13698989","title":"Treatment of hookworm with chlorbetamide, bephenium and tetrachlorethylene.","journal":"The Journal of tropical medicine and hygiene"},{"date":"1960 Mar-Apr","pmid":"13690328","title":"[Comparative study of the activity of chlorophenoxamide and chlorbetamide on Brazilian strains of Endamoeba histolytica and Endamoeba moshkovskii].","journal":"Revista brasileira de gastroenterologia"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mantomide is a small molecule medication. Its synonyms include Chlorbetamide, Clorbetamida, and NSC-16110.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}