{"id":"chloralose","rwe":[{"pmid":"41866898","year":"2026","title":"Effects of craniectomy on cerebrospinal fluid pressure gradient in the craniospinal space in different body positions of cats.","finding":"","journal":"Croatian medical journal","studyType":"Clinical Study"},{"pmid":"41546560","year":"2026","title":"Inflammatory pain alters colorectal motility via spinal oxytocinergic pathways.","finding":"","journal":"American journal of physiology. Gastrointestinal and liver physiology","studyType":"Clinical Study"},{"pmid":"41274141","year":"2025","title":"Reversal of fentanyl-induced laryngospasm with ketanserin and naloxone: A prospective randomized blinded study in rats.","finding":"","journal":"Drug and alcohol dependence","studyType":"Clinical Study"},{"pmid":"40985205","year":"2025","title":"Overview of pesticide exposures reported to the Moroccan Poison Control and Pharmacovigilance Center between 1980 and 2021.","finding":"","journal":"Clinical toxicology (Philadelphia, Pa.)","studyType":"Clinical Study"},{"pmid":"40863939","year":"2025","title":"Exposure of Domestic Cats (Felis catus) to Rodenticidal Compounds.","finding":"","journal":"Toxics","studyType":"Clinical Study"}],"tags":[{"label":"chloralose","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anesthetics","category":"pharmacology"},{"label":"Anesthetics, Intravenous","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"},{"label":"Hypnotics and Sedatives","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"chloralosane","offLabel":[],"synonyms":["chloralose","anhydroglucochloral","chloralosane","glucochloral","glucochloralose","kalmettumsomniferum","alphachloralose"],"timeline":[],"approvals":[],"brandName":"Chloralosane","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"chloralose","explanation":"Think of glycogen like a stored battery for your body's energy needs. Chloralose helps to block the release of energy from this stored battery, which can be useful in certain medical situations. However, this process can also have unintended effects on the body's energy balance and metabolism.","oneSentence":"Chloralose works by inhibiting the enzyme glycogen phosphorylase, which plays a key role in glycogenolysis.","technicalDetail":"Chloralose acts as a competitive inhibitor of glycogen phosphorylase, specifically targeting the enzyme's active site and preventing the breakdown of glycogen into glucose-1-phosphate."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3086","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CHLORALOSE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:32:08.721357","biosimilars":[],"competitors":[],"genericName":"chloralose","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006147","UNII":"238BZ29MUE","CHEBI":"CHEBI:81902","INN_ID":"4082","UMLSCUI":"C0008162","ChEMBL_ID":"CHEMBL2104181","PUBCHEM_CID":"7057995","MESH_DESCRIPTOR_UI":"D002698"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5127,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 20","pmid":"41866898","title":"Effects of craniectomy on cerebrospinal fluid pressure gradient in the craniospinal space in different body positions of cats.","journal":"Croatian medical journal"},{"date":"2026 Feb 1","pmid":"41546560","title":"Inflammatory pain alters colorectal motility via spinal oxytocinergic pathways.","journal":"American journal of physiology. Gastrointestinal and liver physiology"},{"date":"2025 Dec 1","pmid":"41274141","title":"Reversal of fentanyl-induced laryngospasm with ketanserin and naloxone: A prospective randomized blinded study in rats.","journal":"Drug and alcohol dependence"},{"date":"2025 Nov","pmid":"40985205","title":"Overview of pesticide exposures reported to the Moroccan Poison Control and Pharmacovigilance Center between 1980 and 2021.","journal":"Clinical toxicology (Philadelphia, Pa.)"},{"date":"2025 Aug 7","pmid":"40863939","title":"Exposure of Domestic Cats (Felis catus) to Rodenticidal Compounds.","journal":"Toxics"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chloralosane, also known as alpha-chloralose, is a small molecule. It has various synonyms, including ALFAMAT, alpha-chloralose, and alphakil.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}