{"id":"chitosan-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or itching at application site"},{"rate":null,"effect":"Allergic reaction (rare, in shellfish-sensitive patients)"}]},"_chembl":{"chemblId":"CHEMBL4594468","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chitosan is a natural polysaccharide derived from chitin that forms a gel matrix capable of absorbing wound exudate, promoting blood clotting, and creating a moist healing environment. Its positive charge allows it to interact with negatively charged cell membranes and bacterial surfaces, providing antimicrobial activity. The gel also facilitates cell proliferation and angiogenesis, supporting tissue repair and regeneration.","oneSentence":"Chitosan gel acts as a biopolymer scaffold that promotes hemostasis, wound healing, and tissue regeneration through its mucoadhesive and antimicrobial properties.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:40:16.365Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wound healing and hemostasis"},{"name":"Topical wound management"}]},"trialDetails":[{"nctId":"NCT07445607","phase":"NA","title":"\"Mulligan Technique vs Phonophoresis With Chitosan for Patellofemoral Pain\"","status":"NOT_YET_RECRUITING","sponsor":"Ahram Canadian University","startDate":"2026-02-15","conditions":"Patellofemoral Pain Syndrome","enrollment":45},{"nctId":"NCT07429812","phase":"NA","title":"Assessment of Topical Application of Chitosan 0.2% Chlorhexidine Gel on Wound Healing in Diabetic Patients","status":"ENROLLING_BY_INVITATION","sponsor":"Tanta University","startDate":"2025-10-12","conditions":"Extraction Socket Healing","enrollment":40},{"nctId":"NCT07388888","phase":"PHASE4","title":"Antibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative Pain","status":"NOT_YET_RECRUITING","sponsor":"Ain Shams University","startDate":"2026-02","conditions":"Pulp Necrosis","enrollment":52},{"nctId":"NCT07269093","phase":"NA","title":"Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil","status":"RECRUITING","sponsor":"Universiti Sains Malaysia","startDate":"2025-12-21","conditions":"Hypertrophic Scars","enrollment":120},{"nctId":"NCT04783233","phase":"","title":"Chitogel CSK-4 Gel as Packing in Tympanoplasty Surgery","status":"WITHDRAWN","sponsor":"Henry Ford Health System","startDate":"2021-01-14","conditions":"Tympanoplasty Surgery","enrollment":""},{"nctId":"NCT06782087","phase":"PHASE1","title":"A Comparative Study Between the Efficacy of Diode Laser and Nano-chitosan Gel on Activation of Non-vital in- Office Bleaching Agent","status":"ENROLLING_BY_INVITATION","sponsor":"Misr University for Science and Technology","startDate":"2025-10-15","conditions":"Tooth Discoloration","enrollment":42},{"nctId":"NCT06987981","phase":"NA","title":"Comparing How Burn Wounds and Scars Heal in Children Using Chitosan and Silver Dressings","status":"RECRUITING","sponsor":"Miloš Potkonjak","startDate":"2025-07-21","conditions":"Burns Degree Second, Pediatric","enrollment":40},{"nctId":"NCT06850389","phase":"","title":"PMCF Investigation of Medical Device ChitoCare® Medical","status":"RECRUITING","sponsor":"Primex ehf","startDate":"2025-06-11","conditions":"Dermatitis, Acne, Conditions After Dematosurgical Procedures","enrollment":214},{"nctId":"NCT07119619","phase":"NA","title":"Clinical and Radiographic Outcomes of PRF, Chitosan, and Blood Clot in Regenerative Endodontics of Molars","status":"COMPLETED","sponsor":"Inonu University","startDate":"2022-02-10","conditions":"Regenerative Endodontics","enrollment":28},{"nctId":"NCT06982248","phase":"PHASE2","title":"The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Mansoura University","startDate":"2024-08-15","conditions":"Periodontal Pocket","enrollment":60},{"nctId":"NCT06828978","phase":"NA","title":"Clinical and Radiographic Success Following Regenerative Pulpotomy Using Chitosan Hydrogel Versus Platelet Rich Fibrin in Mature Mandibular Molars","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-02","conditions":"Regenerative Pulpotomy for Symptomatic Pulpitis of Mandibular Permanent Molars With Mature Apices","enrollment":36},{"nctId":"NCT05875506","phase":"NA","title":"Efficacy of Ozone Gel, Doxycycline Saturated Chitosan Dressing Versus Alveogyl","status":"COMPLETED","sponsor":"Minia University","startDate":"2023-05-01","conditions":"Osteitis, Dry Socket","enrollment":60},{"nctId":"NCT05877638","phase":"NA","title":"SWC for Treatment of Superficial Partial-Thickness Burns","status":"TERMINATED","sponsor":"Synedgen, Inc.","startDate":"2023-03-27","conditions":"Burn Wounds","enrollment":2},{"nctId":"NCT06260618","phase":"NA","title":"Effect of Chitodex Gel in Tympanoplasty Surgery","status":"RECRUITING","sponsor":"Central Adelaide Local Health Network Incorporated","startDate":"2021-11-20","conditions":"Tympanic Membrane Perforation, Tympanic Membrane Inflammation, Surgery","enrollment":44},{"nctId":"NCT03522077","phase":"NA","title":"RAVE: Radial Artery Vascular Complication and Resource Utilization","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2018-05-09","conditions":"Angiogram, Percutaneous Coronary Intervention","enrollment":300},{"nctId":"NCT06618560","phase":"NA","title":"Effect of Enamel Matrix Derivative or Hyaluronic Acid on Non-Surgical Treatment of Peri-Implantitis","status":"NOT_YET_RECRUITING","sponsor":"Gazi University","startDate":"2024-11-01","conditions":"Peri-implantitis","enrollment":60},{"nctId":"NCT06567301","phase":"NA","title":"Extracorporeal Shockwave Versus Phonophoresis Using Chitosan-Nanoparticles Gel on Functional and Anatomical Changes Detected With Artificial Intelligence Based Texture Analysis Algorithm in Knee Osteoarthritis Patients: A Double Blind Randomized Controlled Trial","status":"RECRUITING","sponsor":"Cairo University","startDate":"2023-10-25","conditions":"Knee Osteoarthritis, Chitosan Nanoparticles Gel, Artificial Intelligence Texture Analysis Bases Algorithm","enrollment":120},{"nctId":"NCT06533215","phase":"NA","title":"Antimicrobial Efficacy of Nano-Based ICM on E.F","status":"RECRUITING","sponsor":"Tanta University","startDate":"2024-01-02","conditions":"Enterococcus Faecalis Infection, Endodontically Treated Teeth, Endodontic Disease","enrollment":30},{"nctId":"NCT06492811","phase":"PHASE2","title":"Efficacy and Safety of a Hydrogel Containing Cascade Catalytic Enzymes in the Treatment of Diabetic Wounds","status":"ACTIVE_NOT_RECRUITING","sponsor":"The First Affiliated Hospital of University of South China","startDate":"2024-04-01","conditions":"Diabetic Wound","enrollment":49},{"nctId":"NCT06485050","phase":"NA","title":"Photodynamic Therapy and Topical Antifungal for Onychomycosis in Patients With Diabetes.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Universidad Complutense de Madrid","startDate":"2024-04-17","conditions":"Dermatologic Disease, Onychomycosis of Toenail, Diabetic Foot","enrollment":10},{"nctId":"NCT06426199","phase":"PHASE4","title":"Chitosan-Hyaluronate Gel Mixture Vs Hyaluronic for Internal Derangement","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2024-01-17","conditions":"TMJ Disc Disorder","enrollment":20},{"nctId":"NCT06373757","phase":"NA","title":"Chitosan Nano-hydroxyapatite Hydrogel in Non-Surgical Treatment of Intrabony Defect","status":"COMPLETED","sponsor":"October 6 University","startDate":"2023-03-01","conditions":"Chitosan, Nano-hydroxyapatite Hydrogel, Intrabony Defect","enrollment":24},{"nctId":"NCT06135259","phase":"PHASE3","title":"Topical Erythropoietin Hydrogel in Management of Oral Lichen Planus","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2024-05-20","conditions":"Oral Lichen Planus","enrollment":18},{"nctId":"NCT04601532","phase":"PHASE4","title":"Superficial Partial-Thickness Burn Study","status":"TERMINATED","sponsor":"J. Peter Rubin, MD","startDate":"2021-06-11","conditions":"Superficial Partial Thickness Burn","enrollment":26},{"nctId":"NCT06200415","phase":"PHASE2","title":"Glucosamine Sulphate Versus Ginger in Non-Surgical Periodontal Therapy","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2022-11-08","conditions":"Periodontal Pocket","enrollment":30},{"nctId":"NCT01895933","phase":"NA","title":"Efficacy and Safety of the Investigational Device, SurgiShield Anti-Adhesion Barrier Gel","status":"COMPLETED","sponsor":"D.med","startDate":"2012-03","conditions":"Wound Healing","enrollment":33},{"nctId":"NCT06072716","phase":"PHASE1","title":"The Anti-fungal Effect of Miconazol Versus Miconazol-Loaded Chitosan Nanoparticles","status":"COMPLETED","sponsor":"Yasmine gamil","startDate":"2023-01-10","conditions":"Oral Thrush","enrollment":80},{"nctId":"NCT05773911","phase":"NA","title":"Treatment of Advanced Periodontitis With a Chitosan Brush and a Chitosan Gel","status":"UNKNOWN","sponsor":"Caspar Wohlfahrt","startDate":"2023-03-23","conditions":"Periodontitis, Periodontal Pocket, Periodontal Diseases","enrollment":40},{"nctId":"NCT05212311","phase":"NA","title":"Effect of Chitosan Phonophoresis On Cubital Tunnel Syndrome","status":"COMPLETED","sponsor":"October 6 University","startDate":"2022-03-08","conditions":"Cubital Tunnel Syndrome, Ulnar Nerve Entrapment at Elbow, Ulnar Nerve Compression","enrollment":54},{"nctId":"NCT05214807","phase":"PHASE4","title":"Long-term Safety and Performance of KiOmedine CM-Chitosan Supplementation in Advanced Symptomatic Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Kiomed Pharma","startDate":"2022-01-26","conditions":"Osteoarthritis, Knee","enrollment":104},{"nctId":"NCT05683782","phase":"PHASE4","title":"Erythropoietin Gel as an Adjunct to Split-Thickness Apically Positioned Flap in Augmentation of Attached Gingiva","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2022-10-01","conditions":"Erythropoietin, Recession","enrollment":20},{"nctId":"NCT04219358","phase":"PHASE1","title":"Topical Application of Imiquimod Gel at Different Concentrations in Actinic Cheilitis","status":"TERMINATED","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2019-03-23","conditions":"Actinic Cheilitis","enrollment":49},{"nctId":"NCT05475444","phase":"NA","title":"PLGA Nanoparticles Entrapping Ciprofloxacin to Treat E-Fecalis Infections in Endodontics","status":"COMPLETED","sponsor":"British University In Egypt","startDate":"2020-03-01","conditions":"Bacterial Infections Oral","enrollment":55},{"nctId":"NCT05079802","phase":"PHASE3","title":"Clinical & Radiographic Evaluation of LSTR in Non-vital Primary Molars Using Two Different Vehicles","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2021-12-01","conditions":"Resorption of Tooth or Root","enrollment":36},{"nctId":"NCT04836078","phase":"EARLY_PHASE1","title":"Role of Simvastatin Microsponges in Treatment of Periodontitis","status":"COMPLETED","sponsor":"Assiut University","startDate":"2020-02-10","conditions":"Periodontitis","enrollment":24},{"nctId":"NCT04178525","phase":"NA","title":"Clinical Trial Evaluating the Safety and Efficacy of the Use of Chitosan Gel in Patients With Chronic Wounds","status":"TERMINATED","sponsor":"Primex ehf","startDate":"2018-08-02","conditions":"Diabetic Foot Ulcer","enrollment":46},{"nctId":"NCT04211597","phase":"NA","title":"EGF-loaded Chitosan to Facilitate Healing and Prevent Scar Formation of Cesarean Wound","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2017-09-05","conditions":"Cesarean Wound, Scar; Previous Cesarean Section, Complicating Pregnancy or Childbirth, Affecting Fetus or Newborn","enrollment":60},{"nctId":"NCT03724266","phase":"NA","title":"Effect of Using Nanochitosan Versus Calcium Hydroxide as Disinfectant on Pain and Apical Bone Healing","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2018-10","conditions":"Postoperative Pain, Healing","enrollment":60},{"nctId":"NCT03588351","phase":"NA","title":"Chitosan,Chitosan Nanoparticles,and Chlorhexidine Gluconate, as Intra Canal Medicaments in Primary Teeth","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2018-01-01","conditions":"Necrotic Pulp","enrollment":45},{"nctId":"NCT03188289","phase":"PHASE4","title":"Microbial Growth in the Suture Thread, After Application of Different Antiseptic Gels in Mandibular Third Molars Extraction","status":"COMPLETED","sponsor":"University of Santiago de Compostela","startDate":"2014-01-20","conditions":"Wisdom Teeth, Oral Surgery, Third Molar Surgery","enrollment":21},{"nctId":"NCT02890277","phase":"NA","title":"Nonneoplastic Epithelial Disorders of Vulva and High Intensity Focused Ultrasound","status":"UNKNOWN","sponsor":"Jinan Military General Hospital","startDate":"2016-01","conditions":"Vulva Intraepithelial Nonneoplastic","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":412,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CS","polymers","hydroxyapatite hydrogel","miconaz oral gel"],"phase":"marketed","status":"active","brandName":"chitosan gel","genericName":"chitosan gel","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chitosan gel acts as a biopolymer scaffold that promotes hemostasis, wound healing, and tissue regeneration through its mucoadhesive and antimicrobial properties. Used for Wound healing and hemostasis, Topical wound management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}