{"id":"chinese-dt-vaccine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain, redness, or swelling"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Myalgia"},{"rate":null,"effect":"Fatigue"}]},"_chembl":null,"_fixedAt":"2026-03-30T13:56:32.904849","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a toxoid-based vaccine containing inactivated diphtheria and tetanus toxins that have been chemically treated to eliminate their toxicity while preserving immunogenicity. The vaccine trains the adaptive immune system to recognize and neutralize diphtheria and tetanus toxins, providing protection against these bacterial diseases through both humoral (antibody) and cell-mediated immune responses.","oneSentence":"The Chinese DT vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria and tetanus toxins.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:05:38.105Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of diphtheria and tetanus in pediatric and adult populations"}]},"_fixedFields":["pubmed(3)"],"trialDetails":[{"nctId":"NCT00452686","phase":"PHASE3","title":"Study to Assess Safety & Immunogenicity of GSK Biologicals' Boostrix (dTpa) Vaccine vs. Chinese DT Vaccine","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2007-03","conditions":"Diphtheria, Acellular Pertussis, Tetanus","enrollment":660}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"recentPublications":[{"date":"2025 Nov 29","pmid":"41318685","title":"Immunogenicity and safety of co-purified diphtheria, tetanus and acellular pertussis vaccine in 6-year-old Chinese children.","journal":"Nature communications"},{"date":"2025 Nov 6","pmid":"41287323","title":"[Evaluation of the protective effect of acellular DPT vaccine for booster immunization in 6-year-old children].","journal":"Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]"},{"date":"2001 Nov","pmid":"11694665","title":"Sustained efficacy during the first 6 years of life of 3-component acellular pertussis vaccines administered in infancy: the Italian experience.","journal":"Pediatrics"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Boostrix"],"phase":"phase_3","status":"active","brandName":"Chinese DT vaccine","genericName":"Chinese DT vaccine","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Biologic","firstApprovalDate":"","aiSummary":"The Chinese DT vaccine stimulates the immune system to produce antibodies and cellular immunity against diphtheria and tetanus toxins. Used for Prevention of diphtheria and tetanus in pediatric and adult populations.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}