{"id":"chg-ipa-surgical-skin-preparation","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or erythema"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, while isopropyl alcohol provides rapid antimicrobial activity and promotes quick drying. Together, they create a synergistic effect that reduces the microbial load on skin before surgical procedures, thereby lowering the risk of surgical site infections.","oneSentence":"CHG/IPA is a surgical skin antiseptic that combines chlorhexidine gluconate (CHG) and isopropyl alcohol (IPA) to rapidly kill bacteria and reduce surgical site infections.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:45:03.552Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical skin preparation and antisepsis prior to surgery"}]},"trialDetails":[{"nctId":"NCT06733506","phase":"PHASE4","title":"A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs","status":"COMPLETED","sponsor":"Gabriel John Culbert","startDate":"2018-10-01","conditions":"Opioid Use Disorder, Injection Drug Use, Skin and Soft Tissue Infections (SSTIs)","enrollment":56},{"nctId":"NCT01968356","phase":"PHASE3","title":"In-vivo Efficacy Study of Patient Preoperative Preps","status":"TERMINATED","sponsor":"Solventum US LLC","startDate":"2013-10","conditions":"Skin Flora Bacterial Reduction Post-product Application","enrollment":171},{"nctId":"NCT01968707","phase":"PHASE3","title":"In-vivo Efficacy Study of Patient Pre-operative Preps","status":"COMPLETED","sponsor":"Solventum US LLC","startDate":"2013-10","conditions":"Bacterial Reduction on Skin Flora Post-product Application","enrollment":426},{"nctId":"NCT02447497","phase":"PHASE2","title":"In Vivo Patient Preoperative Skin Prep Persistence","status":"COMPLETED","sponsor":"Solventum US LLC","startDate":"2015-03","conditions":"Bacterial Recovery of Skin Flora Post-Product Application","enrollment":27},{"nctId":"NCT03681990","phase":"PHASE2","title":"In Vivo Preoperative Skin Preparation Efficacy Study Within a Defined Product Coverage Area","status":"COMPLETED","sponsor":"Solventum US LLC","startDate":"2017-06-06","conditions":"Surgical Skin Preparation, Surgical Procedure, Unspecified","enrollment":28},{"nctId":"NCT04756154","phase":"PHASE3","title":"Efficacy Study of Patient Preoperative Preps In-vivo","status":"COMPLETED","sponsor":"Solventum US LLC","startDate":"2020-07-06","conditions":"Surgical Skin Preparation","enrollment":154},{"nctId":"NCT02203591","phase":"PHASE3","title":"In Vivo Efficacy Study of Patient Preoperative Preps","status":"COMPLETED","sponsor":"3M","startDate":"2014-07","conditions":"Bacterial Reduction Post-product Application","enrollment":738},{"nctId":"NCT02221232","phase":"PHASE2","title":"Efficacy Study to Evaluate Antimicrobial Effectiveness of ZuraPrep™","status":"TERMINATED","sponsor":"Zurex Pharma, Inc.","startDate":"2014-08","conditions":"Surgical Site Infection","enrollment":64},{"nctId":"NCT00739583","phase":"PHASE4","title":"Visibility of Site Marking for Surgical Time Out With Two Different Skin Preparation Solutions","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2008-08","conditions":"Arthroplasty, Replacement, Hip","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["2% CHG/70% IPA"],"phase":"phase_3","status":"active","brandName":"CHG/IPA Surgical skin preparation","genericName":"CHG/IPA Surgical skin preparation","companyName":"Solventum US LLC","companyId":"solventum-us-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"CHG/IPA is a surgical skin antiseptic that combines chlorhexidine gluconate (CHG) and isopropyl alcohol (IPA) to rapidly kill bacteria and reduce surgical site infections. Used for Surgical skin preparation and antisepsis prior to surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}