{"id":"chg-2-w-v-and-ipa-70-v-v","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or erythema"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Allergic reaction (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"CHG is a broad-spectrum antimicrobial that binds to and disrupts bacterial cell membranes, while IPA acts as a rapid-acting antiseptic that denatures proteins and evaporates quickly. Together, the 2% CHG and 70% IPA formulation provides both immediate antimicrobial activity and sustained residual protection, making it effective for skin antisepsis and disinfection.","oneSentence":"Chlorhexidine gluconate (CHG) and isopropyl alcohol (IPA) work synergistically to rapidly kill bacteria and other microorganisms on skin through disruption of cell membranes and protein denaturation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:18.049Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skin antisepsis and preoperative skin preparation"},{"name":"Prevention of surgical site infections"},{"name":"Skin disinfection and hygiene"}]},"trialDetails":[{"nctId":"NCT00799812","phase":"PHASE3","title":"Test for Pre Operative Skin Preparations","status":"COMPLETED","sponsor":"C. R. Bard","startDate":"2007-11-13","conditions":"Topical Antisepsis","enrollment":335},{"nctId":"NCT06733506","phase":"PHASE4","title":"A Pilot Study to Evaluate Skin Swabbing With Chlorhexidine to Prevent Skin And Soft Tissue Infections Among People Who Inject Drugs","status":"COMPLETED","sponsor":"Gabriel John Culbert","startDate":"2018-10-01","conditions":"Opioid Use Disorder, Injection Drug Use, Skin and Soft Tissue Infections (SSTIs)","enrollment":56},{"nctId":"NCT01968707","phase":"PHASE3","title":"In-vivo Efficacy Study of Patient Pre-operative Preps","status":"COMPLETED","sponsor":"Solventum US LLC","startDate":"2013-10","conditions":"Bacterial Reduction on Skin Flora Post-product Application","enrollment":426},{"nctId":"NCT03861780","phase":"PHASE3","title":"Pilot Evaluation of Two Test Materials With a Positive Control When Used as a Patient Preoperative Skin Preparation","status":"COMPLETED","sponsor":"Professional Disposables International, Inc.","startDate":"2019-04-02","conditions":"Bacteria Microflora Reduction","enrollment":152},{"nctId":"NCT04035161","phase":"","title":"Evaluation of the Antimicrobial Effectiveness of CHG/IPA","status":"COMPLETED","sponsor":"Becton, Dickinson and Company","startDate":"2019-04-17","conditions":"Microbial Colonization","enrollment":1935},{"nctId":"NCT00739583","phase":"PHASE4","title":"Visibility of Site Marking for Surgical Time Out With Two Different Skin Preparation Solutions","status":"COMPLETED","sponsor":"Johns Hopkins University","startDate":"2008-08","conditions":"Arthroplasty, Replacement, Hip","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Chloraprep® (CHG 2% w/v and IPA 70% v/v; Enturia Inc., Leawood, KS, USA)"],"phase":"marketed","status":"active","brandName":"CHG 2% w/v and IPA 70% v/v","genericName":"CHG 2% w/v and IPA 70% v/v","companyName":"Johns Hopkins University","companyId":"johns-hopkins-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorhexidine gluconate (CHG) and isopropyl alcohol (IPA) work synergistically to rapidly kill bacteria and other microorganisms on skin through disruption of cell membranes and protein denaturation. Used for Skin antisepsis and preoperative skin preparation, Prevention of surgical site infections, Skin disinfection and hygiene.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}