{"id":"chemotherapy-with-platine","safety":{"commonSideEffects":[{"rate":null,"effect":"Nephrotoxicity"},{"rate":null,"effect":"Ototoxicity"},{"rate":null,"effect":"Myelosuppression"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Peripheral neuropathy"},{"rate":null,"effect":"Anemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Platinum compounds (such as cisplatin, carboplatin, or oxaliplatin) bind to DNA and create interstrand crosslinks, disrupting DNA synthesis and repair mechanisms. This leads to cell cycle arrest and programmed cell death in rapidly dividing cancer cells. Platinum agents are non-cell-cycle-specific and are among the most effective cytotoxic chemotherapy drugs for solid tumors.","oneSentence":"Platinum-based chemotherapy agents form DNA crosslinks that prevent cancer cell replication and induce apoptosis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:05:35.086Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Lung cancer (thoracic malignancies)"},{"name":"Various solid tumors (as part of combination chemotherapy regimens)"}]},"trialDetails":[{"nctId":"NCT07205731","phase":"PHASE2","title":"Phase II Study Evaluating Safety and Efficacy of Tislelizumab for Elderly Patients Unfit for Chemotherapy, With Advanced Esophageal Squamous-cell Carcinoma","status":"RECRUITING","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2025-10-07","conditions":"Esophageal Squamous Cell Carcinoma (ESCC)","enrollment":95},{"nctId":"NCT06727214","phase":"","title":"Survival Benefits of Neoadjuvant Systemic Chemotherapy in Muscle Invasive Bladder Cancer","status":"NOT_YET_RECRUITING","sponsor":"Sara Mahmoud Ahmed Mahmoud","startDate":"2025-11-04","conditions":"Bladder Urothelial Carcinoma","enrollment":87},{"nctId":"NCT06827353","phase":"","title":"Niraparib Versus Bevacizumab as Maintenance Therapy in Patients With de Novo Ovarian Cancer Without Homologous Recombination Deficiency","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2020-10-01","conditions":"Ovarian Carcinoma","enrollment":300},{"nctId":"NCT03752216","phase":"PHASE4","title":"NIraparib and Quality of LifE is a Longitudinal Study Evaluating in Real Life the Tolerability of Niraparib.","status":"COMPLETED","sponsor":"ARCAGY/ GINECO GROUP","startDate":"2019-04-03","conditions":"Ovarian Cancer","enrollment":141},{"nctId":"NCT02477644","phase":"PHASE3","title":"Platine, Avastin and OLAparib in 1st Line","status":"COMPLETED","sponsor":"Arcagy Research","startDate":"2015-05-06","conditions":"Ovarian Cancer","enrollment":806},{"nctId":"NCT00535275","phase":"PHASE3","title":"NSCLC Relapse Therapy After Surgery and Peri-operative Chemotherapy","status":"TERMINATED","sponsor":"Intergroupe Francophone de Cancerologie Thoracique","startDate":"2007-09","conditions":"Carcinoma, Non-Small-Cell Lung","enrollment":88}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":28,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Chemotherapy with platine","genericName":"Chemotherapy with platine","companyName":"Intergroupe Francophone de Cancerologie Thoracique","companyId":"intergroupe-francophone-de-cancerologie-thoracique","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Platinum-based chemotherapy agents form DNA crosslinks that prevent cancer cell replication and induce apoptosis. Used for Lung cancer (thoracic malignancies), Various solid tumors (as part of combination chemotherapy regimens).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}