{"id":"chemodenervation-4-months","safety":{"commonSideEffects":[{"rate":null,"effect":"Muscle weakness or paralysis at injection site"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site pain or bruising"},{"rate":null,"effect":"Flu-like symptoms"},{"rate":null,"effect":"Antibody formation (reduced efficacy over time)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin cleaves SNARE proteins required for acetylcholine vesicle release, preventing muscle contraction. The effect is temporary, lasting approximately 3–4 months, after which neuromuscular function gradually recovers as new nerve terminals form. This mechanism is exploited therapeutically to reduce muscle hyperactivity in various conditions.","oneSentence":"Chemodenervation uses botulinum toxin to temporarily paralyze muscles by blocking acetylcholine release at the neuromuscular junction.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:30:04.000Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Muscle spasticity and hypertonicity"},{"name":"Dystonia"},{"name":"Migraine prophylaxis"},{"name":"Hyperhidrosis"},{"name":"Cosmetic applications"}]},"trialDetails":[{"nctId":"NCT07348952","phase":"NA","title":"Different Transcutaneous Electrical Nerve Stimulation Modes in Pudendal Neuralgia Post-prostatectomy","status":"COMPLETED","sponsor":"Cairo University","startDate":"2023-09-01","conditions":"Transcutaneous Electrical Nerve Stimulation, Pudendal Neuralgia, Post Prostatectomy","enrollment":60},{"nctId":"NCT03007420","phase":"PHASE3","title":"A Prospective Controlled Treatment Trial for Post-Traumatic Headaches","status":"TERMINATED","sponsor":"Boston Children's Hospital","startDate":"2018-01-02","conditions":"Post-Traumatic Headaches","enrollment":16},{"nctId":"NCT06806319","phase":"PHASE2","title":"Assessment of Growth Factors Levels Associated with Wound Healing After Soft Tissue Crown Lengthening","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2021-10-03","conditions":"Gingival Overgrowth","enrollment":80},{"nctId":"NCT06114121","phase":"PHASE4","title":"Intrathecal Morphine vs. Intrathecal Morphine and Regional Anesthesia After Cesarean Section.","status":"WITHDRAWN","sponsor":"University of Miami","startDate":"2024-07-10","conditions":"Post-operative Pain","enrollment":""},{"nctId":"NCT06036043","phase":"","title":"Botulinum Toxin for Chronic Neuropathic Pain","status":"UNKNOWN","sponsor":"Region Zealand","startDate":"2023-08-01","conditions":"Neuralgia, Chronic Pain","enrollment":12},{"nctId":"NCT04750967","phase":"NA","title":"Amitriptyline vs GON and SON Blocks in Migraine","status":"COMPLETED","sponsor":"Dr. Lutfi Kirdar Kartal Training and Research Hospital","startDate":"2021-04-03","conditions":"Migraine, Headache","enrollment":57},{"nctId":"NCT04148872","phase":"PHASE4","title":"Mixed Methods Investigation of Chronic Facial Paralysis in Individuals With Synkinesis","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2019-10-24","conditions":"Synkinesis","enrollment":15}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["onabotulinumtoxin A","Botox","incobotulinumtoxin A","Xeomin"],"phase":"marketed","status":"active","brandName":"Chemodenervation (4 months)","genericName":"Chemodenervation (4 months)","companyName":"University of Wisconsin, Madison","companyId":"university-of-wisconsin-madison","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chemodenervation uses botulinum toxin to temporarily paralyze muscles by blocking acetylcholine release at the neuromuscular junction. Used for Muscle spasticity and hypertonicity, Dystonia, Migraine prophylaxis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}