{"id":"cetyl-alcohol","rwe":[{"pmid":"41681259","year":"2026","title":"The Use of Bioadditives as Plasticizers in Recycled Polyethylene Materials.","finding":"","journal":"Materials (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41492008","year":"2026","title":"Combined extraction and spray-freeze-drying of Cannabis sativa Flos provides stable lyophilizate particles of cannabinoids.","finding":"","journal":"Journal of cannabis research","studyType":"Clinical Study"},{"pmid":"41444726","year":"2025","title":"Sustainable application of edible solute to control reservoir evaporation loss.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"41255865","year":"2025","title":"Synthesis and characterization of a modified diatomite-based hybrid shell microcapsule for thermal energy storage.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"40978887","year":"2025","title":"Clinical Evaluation of a Soap-Free Cleansing Lotion Containing Sodium Cocoyl Apple Amino Acids for Effective Impurity Removal and Skin Barrier Preservation in Healthy Adults With Diverse Skin Types.","finding":"","journal":"Cureus","studyType":"Clinical Study"}],"tags":[{"label":"cetyl alcohol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Topical","category":"route"},{"label":"Cream","category":"form"},{"label":"Lotion","category":"form"},{"label":"Active","category":"status"},{"label":"Respiratory distress syndrome in the newborn","category":"indication"},{"label":"Glaxosmithkline","category":"company"},{"label":"Approved 1990s","category":"decade"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"GSK","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CETYL ALCOHOL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:05:58.824522+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:06:04.917230+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CETYL ALCOHOL","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:06:05.378650+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL706/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:06:06.373866+00:00"}},"allNames":"cetanol","offLabel":[],"synonyms":["cetyl alcohol","cetaffine","1-Hexadecanol","cetanol","cetylic alcohol","cetylol","palmitic alcohol","palmityl alcohol"],"timeline":[{"date":"1990-08-02","type":"positive","source":"DrugCentral","milestone":"FDA approval (Glaxosmithkline)"}],"approvals":[{"date":"1990-08-02","orphan":true,"company":"GLAXOSMITHKLINE","regulator":"FDA"}],"brandName":"Cetanol","ecosystem":[{"indication":"Respiratory distress syndrome in the newborn","otherDrugs":[{"name":"beractant","slug":"beractant","company":"Abbvie"},{"name":"calfactant","slug":"calfactant","company":"Ony"},{"name":"colfosceril palmitate","slug":"colfosceril-palmitate","company":"Glaxosmithkline"},{"name":"lucinactant","slug":"lucinactant","company":"Discovery Labs"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"cetyl alcohol","explanation":"","oneSentence":"","technicalDetail":"Cetanol functions as a pulmonary surfactant, reducing the interfacial tension between the air-liquid interface in the alveoli, thereby facilitating gas exchange and lung expansion."},"commercial":{"launchDate":"1990","_launchSource":"DrugCentral (FDA 1990-08-02, GLAXOSMITHKLINE)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4750","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CETYL%20ALCOHOL","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CETYL ALCOHOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:32:19.149902","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:06:07.944662+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"cetyl alcohol","indications":{"approved":[{"name":"Respiratory distress syndrome in the newborn","source":"DrugCentral","snomedId":46775006,"regulator":"FDA","eligibility":"Newborns"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06750653","phase":"PHASE4","title":"Skin Barrier Function and Inflammation in Aging: The BIA Study","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2025-02-06","conditions":["Inflammation","Skin Inflammation","Aging"],"enrollment":32,"completionDate":"2026-04-15"},{"nctId":"NCT07398989","phase":"PHASE4","title":"A Clinical Study to Assess Efficacy and Tolerability of a Topical Skincare Product on Adults With Mature, Crepey Skin","status":"RECRUITING","sponsor":"Galderma R&D","startDate":"2025-08-12","conditions":["Crepey Skin","Aging Skin","Photo-aged Skin"],"enrollment":30,"completionDate":"2026-03"},{"nctId":"NCT02218463","phase":"NA","title":"Treatment of Prepubertal Labial Adhesions","status":"COMPLETED","sponsor":"Children's Mercy Hospital Kansas City","startDate":"2014-09","conditions":["Prepubertal Labial Adhesions"],"enrollment":43,"completionDate":"2016-06"},{"nctId":"NCT04173247","phase":"NA","title":"Study of KeraStat Cream for Radiation Dermatitis During Head and Neck Radiotherapy","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2020-07-27","conditions":["Head and Neck Cancer","Radiation Dermatitis"],"enrollment":28,"completionDate":"2022-10-07"},{"nctId":"NCT06357221","phase":"PHASE4","title":"A Study to Assess Efficacy and Tolerability of Topical Skincare Products on Psoriasis Patients","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2024-04-08","conditions":["Plaque Psoriasis","Psoriasis"],"enrollment":46,"completionDate":"2024-07-18"},{"nctId":"NCT06122467","phase":"NA","title":"A Single Group Study to Evaluate the Efficacy of a Cosmetic Product Line on Acne Symptoms","status":"COMPLETED","sponsor":"Menning Labs","startDate":"2023-10-02","conditions":["Acne"],"enrollment":36,"completionDate":"2023-12-31"},{"nctId":"NCT06125912","phase":"NA","title":"A Comparative Split-Face Study of the Effects of a Retinol Alternative Cream on Improving Facial Skin Aging","status":"COMPLETED","sponsor":"Dime Beauty Co.","startDate":"2023-09-25","conditions":["Skin Aging"],"enrollment":35,"completionDate":"2024-02-15"},{"nctId":"NCT06146712","phase":"NA","title":"A Single-Group Study to Examine the Efficacy of a Melatonin Lotion With Magnesium to Improve Sleep Quality and Quantity","status":"COMPLETED","sponsor":"Asutra","startDate":"2023-08-07","conditions":["Sleep"],"enrollment":35,"completionDate":"2023-10-02"},{"nctId":"NCT05886673","phase":"NA","title":"Development of a Protective Cream Against Radiodermatitis Caused by Radiotherapy.","status":"UNKNOWN","sponsor":"Antonio J. Conde Moreno","startDate":"2023-03-29","conditions":["Radiodermatitis"],"enrollment":5,"completionDate":"2023-12"},{"nctId":"NCT05892081","phase":"PHASE4","title":"Colloidal Oatmeal, Colloid Cream, Diaper Rash, Preterm Neonates and Neonatal Intensive Care Unit","status":"COMPLETED","sponsor":"Seham El-Sayed Saleh Hassan","startDate":"2021-08-20","conditions":["Diaper Rash","Preterm Neonates"],"enrollment":90,"completionDate":"2023-08-30"},{"nctId":"NCT05514782","phase":"NA","title":"A Clinical Study to Evaluate the Long-Term Efficacy and Tolerability of a Daily Anti-Aging Daily Serum","status":"COMPLETED","sponsor":"Revision Skincare","startDate":"2021-09-15","conditions":["Photoaging","Wrinkle"],"enrollment":67,"completionDate":"2021-12-10"},{"nctId":"NCT05271136","phase":"NA","title":"A Clinical Study to Evaluate the Efficacy of an Anti-Aging Serum","status":"COMPLETED","sponsor":"Revision Skincare","startDate":"2020-09-30","conditions":["Fine Lines","Wrinkle","Photoaging"],"enrollment":26,"completionDate":"2020-10-13"},{"nctId":"NCT04872946","phase":"NA","title":"Topical and Oral Regimen for Skin Health","status":"COMPLETED","sponsor":"Integrative Skin Science and Research","startDate":"2019-11-26","conditions":["Skin Abnormalities"],"enrollment":74,"completionDate":"2020-05-07"},{"nctId":"NCT04835259","phase":"NA","title":"Efficacy of Topical Antioxidants in Tretment of Photoaging","status":"UNKNOWN","sponsor":"Sohag University","startDate":"2021-04","conditions":["Photoaging"],"enrollment":90,"completionDate":"2022-06"},{"nctId":"NCT00971282","phase":"PHASE4","title":"Adjunctive Usage of a Moisturizing Lotion (Cetaphil® Moisturizing Lotion) to Limit the Skin Irritation Linked to the Set-Up of a Treatment by Topical Retinoid (Differin® Gel 0,1%) in Healthy Subjects of Chinese Origins","status":"COMPLETED","sponsor":"Galderma R&D","startDate":"2008-12","conditions":["Healthy Skin"],"enrollment":30,"completionDate":"2009-05"},{"nctId":"NCT04253704","phase":"PHASE1,PHASE2","title":"Effects of 2% IDL Lotion on Skin Hydration and Transepidermal Water Loss in Females With Dry Skin","status":"COMPLETED","sponsor":"Shyla Cantor","startDate":"2017-02-13","conditions":["Xerosis Cutis"],"enrollment":16,"completionDate":"2017-03-03"},{"nctId":"NCT03350893","phase":"NA","title":"Efficacy Evaluation of the Probiotics Containing Skincare Products on Skin","status":"COMPLETED","sponsor":"GenMont Biotech Incorporation","startDate":"2017-09-18","conditions":["Skin Problems"],"enrollment":20,"completionDate":"2018-08-31"},{"nctId":"NCT00754247","phase":"PHASE4","title":"A Randomized Comparative Study Evaluating the Tolerability and Efficacy of Two Topical Therapies for the Treatment of Keloids and Hypertrophic Scars","status":"COMPLETED","sponsor":"University of Miami","startDate":"2006-03","conditions":["Keloid","Hypertrophic Scar","Cicatrix, Hypertrophic"],"enrollment":30,"completionDate":"2008-02"},{"nctId":"NCT00693654","phase":"PHASE4","title":"Comparative Study of the Efficacy of SARNA Sensitive Lotion for Treatment of Uremic Itch in Adult Hemodialysis Patients","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2006-11","conditions":["Pruritis"],"enrollment":28,"completionDate":"2008-10"},{"nctId":"NCT00655811","phase":"PHASE4","title":"Ethnic Differences in Response to Topical Capsaicin: A Psychophysical Study on Healthy Subjects","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2008-02","conditions":["Healthy"],"enrollment":40,"completionDate":"2009-10"},{"nctId":"NCT03037541","phase":"PHASE3","title":"Cryosurgery and Cream Combination for Actinic Keratosis","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2011-01-05","conditions":["Actinic Keratosis"],"enrollment":60,"completionDate":"2013-10-29"},{"nctId":"NCT02099006","phase":"PHASE2,PHASE3","title":"Novel Topical Therapies for the Treatment of Genital Pain","status":"COMPLETED","sponsor":"University of Rochester","startDate":"2013-11","conditions":["Female Genital Diseases"],"enrollment":9,"completionDate":"2015-06"},{"nctId":"NCT01847157","phase":"NA","title":"Transcranial Direct Current Stimulation Combined Sensory Modulation Intervention in Chronic Stroke Patients","status":"COMPLETED","sponsor":"National Taiwan University Hospital","startDate":"2013-01","conditions":["Stroke"],"enrollment":25,"completionDate":"2015-06"},{"nctId":"NCT01898182","phase":"PHASE4","title":"Efficacy and Safety of Kinetin 0.1% for Treatment of Skin Photoaging","status":"COMPLETED","sponsor":"Makati Medical Center","startDate":"2013-11","conditions":["Cutaneous Photoaging"],"enrollment":132,"completionDate":"2014-09"},{"nctId":"NCT00924508","phase":"NA","title":"Hydrogel Patch for the Treatment of Eczema","status":"TERMINATED","sponsor":"University of California, San Francisco","startDate":"2008-07","conditions":["Eczema"],"enrollment":23,"completionDate":"2012-07"},{"nctId":"NCT01542138","phase":"PHASE4","title":"Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation","status":"COMPLETED","sponsor":"Universidad Autonoma de San Luis Potosí","startDate":"2011-07","conditions":["Hyperpigmentation"],"enrollment":28,"completionDate":"2012-11"},{"nctId":"NCT01580943","phase":"PHASE1,PHASE2","title":"Efficacy of Two Commercially Available Chlorhexidine Mouthrinses Non-alcohol Base","status":"COMPLETED","sponsor":"Universidade do Porto","startDate":"2011-10","conditions":["Dental Plaque"],"enrollment":50,"completionDate":"2012-03"},{"nctId":"NCT01115049","phase":"PHASE4","title":"Hexetidine and Chlorobutanol for Lesions Due to Prostheses","status":"COMPLETED","sponsor":"Federico II University","startDate":"2010-02","conditions":["Oral Mucositis"],"enrollment":44,"completionDate":"2010-03"},{"nctId":"NCT00629317","phase":"PHASE3","title":"Trial of Methyl Aminolevulinate Plus Aktilite in Facial Photodamage","status":"COMPLETED","sponsor":"Universidad de Antioquia","startDate":"2008-02","conditions":["Skin Aging"],"enrollment":49,"completionDate":"2009-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical","formulation":"Cream, Lotion","formulations":[{"form":"CREAM","route":"TOPICAL","productName":"ANUBISMED"},{"form":"CREAM","route":"TOPICAL","productName":"Anubis Barcelona Regul Oil"},{"form":"CREAM","route":"TOPICAL","productName":"Anubis Barcelona Vital Line"},{"form":"LOTION","route":"TOPICAL","productName":"All Day Skin Relief with Colloidal Oats"},{"form":"LOTION","route":"TOPICAL","productName":"Daily Moisturizing with Colloidal Oats"}]},"crossReferences":{"NUI":"N0000145981","MMSL":"NOCODE","NDDF":"002452","UNII":"936JST6JCN","VUID":"4017600","CHEBI":"CHEBI:16125","VANDF":"4017600","RXNORM":"20615","UMLSCUI":"C0055152","chemblId":"CHEMBL706","ChEMBL_ID":"CHEMBL706","KEGG_DRUG":"D00099","DRUGBANK_ID":"DB09494","PDB_CHEM_ID":"PL3","PUBCHEM_CID":"2682","SNOMEDCT_US":"404831000","MESH_SUPPLEMENTAL_RECORD_UI":"C005031"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"1990-","companyName":"GSK","relationship":"Original Developer"}],"publicationCount":222,"therapeuticAreas":["Respiratory"],"biosimilarFilings":[],"originalDeveloper":"Glaxosmithkline","recentPublications":[{"date":"2026 Feb 2","pmid":"41681259","title":"The Use of Bioadditives as Plasticizers in Recycled Polyethylene Materials.","journal":"Materials (Basel, Switzerland)"},{"date":"2026 Jan 6","pmid":"41492008","title":"Combined extraction and spray-freeze-drying of Cannabis sativa Flos provides stable lyophilizate particles of cannabinoids.","journal":"Journal of cannabis research"},{"date":"2025 Dec 24","pmid":"41444726","title":"Sustainable application of edible solute to control reservoir evaporation loss.","journal":"Scientific reports"},{"date":"2025 Nov 11","pmid":"41255865","title":"Synthesis and characterization of a modified diatomite-based hybrid shell microcapsule for thermal energy storage.","journal":"RSC advances"},{"date":"2025 Aug","pmid":"40978887","title":"Clinical Evaluation of a Soap-Free Cleansing Lotion Containing Sodium Cocoyl Apple Amino Acids for Effective Impurity Removal and Skin Barrier Preservation in Healthy Adults With Diverse Skin Types.","journal":"Cureus"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"approved","companyName":"GSK","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"1990","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":"1990-08-02T00:00:00.000Z","mah":"GLAXOSMITHKLINE","brand_name_local":null,"application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":"1990-08-02T00:00:00.000Z","mah":"GLAXOSMITHKLINE","brand_name_local":"EXOSURF NEONATAL","application_number":"NDA020044"},{"country_code":"BR","regulator":"ANVISA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MX","regulator":"COFEPRIS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AR","regulator":"ANMAT","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TR","regulator":"TITCK","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IN","regulator":"CDSCO","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TH","regulator":"FDA-TH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MY","regulator":"NPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"PH","regulator":"FDA-PH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CO","regulator":"INVIMA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"ZA","regulator":"SAHPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TW","regulator":"TFDA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"HK","regulator":"DH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:06:07.944662+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}