{"id":"cetrorelix-acetate-and-follitropin-alfa","safety":{"commonSideEffects":[{"rate":"10%","effect":"Injection site reaction"},{"rate":"8%","effect":"Headache"},{"rate":"6%","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Cetrorelix acetate works by competitively inhibiting the binding of GnRH to its receptor, thereby reducing the release of gonadotropins. Follitropin alfa stimulates the growth and maturation of follicles in the ovaries, leading to ovulation.","oneSentence":"Cetrorelix acetate is a GnRH antagonist, and Follitropin alfa is a recombinant human FSH analogue.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:25:40.747Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ovarian stimulation in assisted reproduction"}]},"trialDetails":[{"nctId":"NCT07340827","phase":"PHASE3","title":"A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)","status":"RECRUITING","sponsor":"Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany","startDate":"2026-02-05","conditions":"Infertility","enrollment":333},{"nctId":"NCT02892942","phase":"PHASE4","title":"NATural Ovarian Stimulation","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2017-01-13","conditions":"Infertility","enrollment":129},{"nctId":"NCT06572930","phase":"","title":"Serum FSH Monitoring for Identification of an Optimal Range During Ovarian Stimulation","status":"RECRUITING","sponsor":"ART Fertility Clinics LLC","startDate":"2024-12-16","conditions":"Ovarian Stimulation","enrollment":150},{"nctId":"NCT06778733","phase":"EARLY_PHASE1","title":"Effectiveness of Low Dose Gonadotropin Stimulation Protocol Vs High Dose Gonadotropin Protocol in Poor Responders","status":"COMPLETED","sponsor":"University of Athens","startDate":"2022-01-01","conditions":"Female Infertility","enrollment":22},{"nctId":"NCT06571214","phase":"PHASE4","title":"Potential Benefit of r-hLH Addition in Patients Aged 35 to 40 Under Ovarian Stimulation Treatment","status":"NOT_YET_RECRUITING","sponsor":"Nanjing University","startDate":"2024-09-01","conditions":"Infertility","enrollment":300},{"nctId":"NCT04719000","phase":"PHASE4","title":"PErsonalized Addition of Recombinant LH in Ovarian Stimulation","status":"RECRUITING","sponsor":"Fundación Santiago Dexeus Font","startDate":"2021-02-04","conditions":"Infertility","enrollment":120},{"nctId":"NCT06199960","phase":"PHASE3","title":"Dual Ovarian Stimulation (Duostim) and Shanghai Protocols in Poor Ovarian Responders","status":"COMPLETED","sponsor":"Royan Institute","startDate":"2019-08-02","conditions":"Assisted Reproductive Techniques","enrollment":116},{"nctId":"NCT04724486","phase":"PHASE4","title":"Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSI","status":"COMPLETED","sponsor":"Damascus University","startDate":"2020-08-22","conditions":"In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility","enrollment":50},{"nctId":"NCT04724343","phase":"PHASE4","title":"Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes.","status":"COMPLETED","sponsor":"Damascus University","startDate":"2019-12-22","conditions":"In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility","enrollment":50},{"nctId":"NCT04727684","phase":"PHASE4","title":"Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSI","status":"COMPLETED","sponsor":"Damascus University","startDate":"2020-08-22","conditions":"In Vitro Fertilization, Infertility, Intracytoplasmic Sperm Injection","enrollment":50},{"nctId":"NCT04727671","phase":"PHASE4","title":"Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients.","status":"COMPLETED","sponsor":"Damascus University","startDate":"2019-12-22","conditions":"In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility","enrollment":50},{"nctId":"NCT04931355","phase":"NA","title":"Acupuncture in the Freeze-all IVF Cycle","status":"UNKNOWN","sponsor":"Peking University Third Hospital","startDate":"2023-06-01","conditions":"Acupuncture, Female Infertility","enrollment":90},{"nctId":"NCT04616729","phase":"PHASE1, PHASE2","title":"DEPO-Trigger Trial: GnRH Agonist DEPOt TRIGGER for Final Oocyte Maturation","status":"UNKNOWN","sponsor":"Universitair Ziekenhuis Brussel","startDate":"2022-11-01","conditions":"Breast Cancer Female","enrollment":30},{"nctId":"NCT05778331","phase":"","title":"The Difference Between POSEIDON Group 3 and Group 4 as Regards IVF","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2023-01-10","conditions":"Infertility, Female, IVF","enrollment":340},{"nctId":"NCT04854707","phase":"","title":"An Observational Study of Follitropin Alpha Biosimilar: the Real-world Data","status":"COMPLETED","sponsor":"IVFarma LLC","startDate":"2020-01-12","conditions":"Reproductive Issues, Reproductive Disorder, Fertility Disorders","enrollment":5484},{"nctId":"NCT04935073","phase":"PHASE3","title":"Traditional Chinese Medicine Herbs in the Freeze-all IVF Cycle","status":"UNKNOWN","sponsor":"Peking University Third Hospital","startDate":"2021-06-15","conditions":"Infertility, Female","enrollment":90},{"nctId":"NCT04842825","phase":"PHASE3","title":"Sequential Therapy of TCM Herbs to Improve the Success Rate of IVF-ET in Diminished Ovarian Reserve Patients","status":"UNKNOWN","sponsor":"Peking University Third Hospital","startDate":"2021-04-15","conditions":"Infertility, Female","enrollment":200},{"nctId":"NCT03181685","phase":"PHASE4","title":"Patients' Preference for Subcutaneous or Vaginal Progesterone as Luteal Support in IVF/ICSI Cycles","status":"TERMINATED","sponsor":"Andros Day Surgery Clinic","startDate":"2016-12-20","conditions":"Infertility, In Vitro Fertilization","enrollment":60},{"nctId":"NCT01112358","phase":"PHASE2","title":"Lutropin Alfa in Women at Risk of Poor Response","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2005-12-07","conditions":"Ovarian Stimulation","enrollment":58},{"nctId":"NCT03118830","phase":"PHASE4","title":"Long Protocol and Freeze All Embryos vs Antagonist Protocol With Fresh Embryo Transfer in PCOS Patients Undergoing ICSI","status":"COMPLETED","sponsor":"Cairo University","startDate":"2017-04-21","conditions":"Invitro Fertilization","enrollment":204},{"nctId":"NCT01590173","phase":"PHASE2, PHASE3","title":"Addition of Prednisolone and Heparin in Patients Undergoing IVF With Failed IVF Cycles","status":"COMPLETED","sponsor":"National and Kapodistrian University of Athens","startDate":"2012-01","conditions":"Infertility","enrollment":86},{"nctId":"NCT01798862","phase":"PHASE2, PHASE3","title":"Endometrial Injury and IVF Outcome Parameters in Patients With Failed IVF Cycles","status":"COMPLETED","sponsor":"National and Kapodistrian University of Athens","startDate":"2013-03","conditions":"Repeated Implantation Failures","enrollment":100},{"nctId":"NCT02442895","phase":"","title":"Biomarkers of Ovarian Reserve and Correlation With IVF Treatments","status":"COMPLETED","sponsor":"U.O.S. Procreazione Medicalmente Assistita e Congelamento Gameti","startDate":"2014-02","conditions":"Pregnancy, Ovarian","enrollment":236},{"nctId":"NCT02437032","phase":"PHASE4","title":"Gonadotropin Type in Ovarian Stimulation","status":"COMPLETED","sponsor":"IVI Madrid","startDate":"2009-04","conditions":"Infertility","enrollment":100},{"nctId":"NCT01109654","phase":"","title":"An Observational Study of Cetrotide® Gonadotropin-releasing Hormone Antagonist (GnRH Antagonist) With GONAL-f® in Assisted Reproductive Technologies (ART)","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2008-09","conditions":"Infertility","enrollment":2175},{"nctId":"NCT00298025","phase":"PHASE4","title":"A Study to Compare the Safety and Efficacy of Cetrotide® 3 Milligram (mg) Versus Antagon™ in Women Undergoing Ovarian Stimulation","status":"COMPLETED","sponsor":"EMD Serono","startDate":"2003-09","conditions":"Infertile Women Undergoing Assisted Reproductive Technology (ART)","enrollment":185},{"nctId":"NCT01225835","phase":"PHASE4","title":"Progesterone Serum Levels in Subfertile Female Patients Undergoing in Vitro Fertilisation (IVF)","status":"COMPLETED","sponsor":"Ferring Pharmaceuticals","startDate":"2010-10","conditions":"Infertility","enrollment":124},{"nctId":"NCT01079949","phase":"PHASE2","title":"A Phase II Study to Assess the Efficacy and Safety of Luveris® (Lutropin Alfa) in Mid Follicular Phase for Controlled Ovarian Stimulation (COS) in Advanced Reproductive Age","status":"TERMINATED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2007-11","conditions":"Infertility, Ovulation Induction","enrollment":93},{"nctId":"NCT01185704","phase":"PHASE3","title":"Analysis of Two Therapeutic With Cetrotide® in Polycystic Ovarian (PCO) Women in Assisted Reproductive Technology (ART)","status":"COMPLETED","sponsor":"Merck KGaA, Darmstadt, Germany","startDate":"2008-11","conditions":"Polycystic Ovarian Syndrome","enrollment":136},{"nctId":"NCT01948804","phase":"PHASE4","title":"The Comparison of Effect of Four Different Treatment Protocols on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization.","status":"UNKNOWN","sponsor":"Pınar Özcan Cenksoy","startDate":"2014-01","conditions":"Poor Responders Undergoing IVF","enrollment":100},{"nctId":"NCT01668056","phase":"NA","title":"Synchronization of Ovarian Stimulation for in Vitro Fertilization With Follicular Wave Emergence","status":"UNKNOWN","sponsor":"University of Sao Paulo General Hospital","startDate":"2012-01","conditions":"Infertility","enrollment":30},{"nctId":"NCT01760278","phase":"PHASE4","title":"Assessment of Implantation Potential of Embryos by Time-lapse Technology","status":"UNKNOWN","sponsor":"Bloom IVF and Fertility Centre","startDate":"2012-12","conditions":"Embryo/Fetus Death, Blastocyst Disintegration, Aneuploidy","enrollment":200},{"nctId":"NCT00883766","phase":"NA","title":"Polycystic Ovary Syndrome (PCOS) and In Vitro Fertilization (IVF): A Comparison Between Standard Long Protocol Versus an Antagonist Protocol Starting on Day 1","status":"TERMINATED","sponsor":"Fundacion Dexeus","startDate":"2009-04","conditions":"Polycystic Ovary Syndrome, In Vitro Fertilization","enrollment":172},{"nctId":"NCT01468441","phase":"NA","title":"Ovarian Stimulation Using Recombinant Follicle-stimulating Hormone (FSH) and Gonadotrophin Releasing Hormone (GnRH) Agonist in Alternate Days","status":"COMPLETED","sponsor":"Fertility - Assisted Fertilization Center","startDate":"2011-09","conditions":"Infertility","enrollment":96},{"nctId":"NCT00439829","phase":"PHASE4","title":"Synchronization of Follicle Wave Emergence and Ovarian Stimulation","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2007-02","conditions":"Infertility","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cetrotide","Gonal-f"],"phase":"phase_2","status":"active","brandName":"Cetrorelix acetate and Follitropin alfa","genericName":"Cetrorelix acetate and Follitropin alfa","companyName":"Merck KGaA, Darmstadt, Germany","companyId":"merck-kgaa-darmstadt-germany","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cetrorelix acetate is a GnRH antagonist, and Follitropin alfa is a recombinant human FSH analogue. Used for Ovarian stimulation in assisted reproduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}