{"id":"cetalkonium-chloride","rwe":[{"pmid":"41467269","year":"2025","title":"Cetalkonium Chloride Induced a Dose-Dependent Toxicity on Corneal Endothelial Cells.","finding":"","journal":"Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics","studyType":"Clinical Study"},{"pmid":"40284517","year":"2025","title":"In Vitro Toxicity of Cetalkonium Chloride on Corneal Epithelial Cells.","finding":"","journal":"Pharmaceutics","studyType":"Clinical Study"},{"pmid":"38743443","year":"2024","title":"Combination of PEGylation and Cationization on Phospholipid-Coated Cyclosporine Nanosuspensions for Enhanced Ocular Drug Delivery.","finding":"","journal":"ACS applied materials & interfaces","studyType":"Clinical Study"},{"pmid":"36933811","year":"2023","title":"Influence of BAKs on tear film lipid layer: In vitro and in silico models.","finding":"","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V","studyType":"Clinical Study"},{"pmid":"34783238","year":"2021","title":"Effects of Benzyl-Functionalized Cationic Surfactants on the Inhibition of the Hydrogen Evolution Reaction in CO(2) Reduction Systems.","finding":"","journal":"ACS applied materials & interfaces","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Infective Agents, Local","category":"pharmacology"},{"label":"Surface-Active Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"cetylon","offLabel":[],"synonyms":["cetalkonium chloride","benzylhexadecyldimethylammonium chloride","benzaletas","benzylcetyldimethylammonium chloride","benzyldimethylcetylammonium chloride","benzyldimethylhexadecylammonium chloride","cetylbenzyldimethylammonium chloride","cetyldimethylbenzylammonium chloride","cetylon","dimethylbenzylcetylammonium chloride","dimethylbenzylhexadecylammonium chloride","hexadecylbenzyldimethylammonium chloride","hexadecyldimethylbenzylammonium chloride"],"timeline":[],"approvals":[],"brandName":"Cetylon","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine Cetylon as a key that fits into a lock on the surface of cells. When it binds, it changes the way the cell membrane works, which can affect how the cell behaves and responds to its environment. This can have various effects on the cell, depending on the specific situation.","oneSentence":"Cetylon works by interacting with cell membranes to alter their structure and function.","technicalDetail":"Cetylon is a quaternary ammonium compound that binds to negatively charged phospholipid headgroups in cell membranes, altering membrane fluidity and permeability."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3078","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=CETALKONIUM%20CHLORIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CETALKONIUM CHLORIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:31:50.610658","biosimilars":[],"competitors":[],"genericName":"cetalkonium chloride","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07082621","phase":"NA","title":"N Acetylcystene in Treatment of Radiotherapy Induced Oral Mucositis in Oral Cancer Patients","status":"COMPLETED","sponsor":"Hams Hamed Abdelrahman","startDate":"2024-01-15","conditions":["Oral Mucositis"],"enrollment":40,"completionDate":"2025-03-09"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000148084","NDDF":"003148","UNII":"85474O1N9D","VUID":"4020066","CHEBI":"CHEBI:135523","VANDF":"4020066","INN_ID":"1843","RXNORM":"47907","UMLSCUI":"C0109105","ChEMBL_ID":"CHEMBL1644450","KEGG_DRUG":"D03448","DRUGBANK_ID":"DB11583","PUBCHEM_CID":"31202","SNOMEDCT_US":"422394006","MESH_SUPPLEMENTAL_RECORD_UI":"C012817"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":25,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Dec 12","pmid":"41467269","title":"Cetalkonium Chloride Induced a Dose-Dependent Toxicity on Corneal Endothelial Cells.","journal":"Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics"},{"date":"2025 Apr 16","pmid":"40284517","title":"In Vitro Toxicity of Cetalkonium Chloride on Corneal Epithelial Cells.","journal":"Pharmaceutics"},{"date":"2024 May 29","pmid":"38743443","title":"Combination of PEGylation and Cationization on Phospholipid-Coated Cyclosporine Nanosuspensions for Enhanced Ocular Drug Delivery.","journal":"ACS applied materials & interfaces"},{"date":"2023 May","pmid":"36933811","title":"Influence of BAKs on tear film lipid layer: In vitro and in silico models.","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"date":"2021 Dec 1","pmid":"34783238","title":"Effects of Benzyl-Functionalized Cationic Surfactants on the Inhibition of the Hydrogen Evolution Reaction in CO(2) Reduction Systems.","journal":"ACS applied materials & interfaces"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cetylon, also known as cetalkonium chloride, is a small molecule compound. Its exact mechanism of action and target are unknown, but it is used in various commercial products. Cetylon is not FDA-approved for any specific indication, and its commercial status is unclear. As a result, there is limited information available on its safety profile and pharmacokinetic properties. Further research is needed to fully understand Cetylon's properties and potential applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}