{"id":"cerazette","safety":{"commonSideEffects":[{"rate":"20-40","effect":"Irregular menstrual bleeding or amenorrhea"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Breast tenderness"},{"rate":"5","effect":"Mood changes"},{"rate":"5","effect":"Acne"},{"rate":"null","effect":"Weight changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cerazette contains desogestrel, a synthetic progestin that works through multiple mechanisms: it alters cervical mucus consistency to impede sperm penetration, suppresses the luteinizing hormone (LH) surge needed for ovulation, and modifies the endometrium to prevent implantation. Unlike combined oral contraceptives, it contains no estrogen, making it suitable for women who cannot tolerate or are contraindicated for estrogen-containing formulations.","oneSentence":"Cerazette is a progestin-only oral contraceptive that prevents pregnancy primarily by thickening cervical mucus and inhibiting ovulation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:17:47.094Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception in women of reproductive age"},{"name":"Contraception in women who cannot use estrogen-containing contraceptives"}]},"trialDetails":[{"nctId":"NCT06175832","phase":"PHASE4","title":"PPOS (Progestin Primed Ovarian Stimulation) and Corifollitropin Alfa (CFA) Cross-over Study","status":"RECRUITING","sponsor":"University Hospital, Ghent","startDate":"2025-01-27","conditions":"Ovarian Stimulation, Quality of Life, Preimplantation Genetic Testing","enrollment":60},{"nctId":"NCT01292785","phase":"","title":"Effects of Sex Steroid Hormones on Human Brain Function, Structure and Connectivity","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2011-01","conditions":"Gender Identity Disorder","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Cerazette®","genericName":"Cerazette®","companyName":"University Hospital, Ghent","companyId":"university-hospital-ghent","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Cerazette is a progestin-only oral contraceptive that prevents pregnancy primarily by thickening cervical mucus and inhibiting ovulation. Used for Contraception in women of reproductive age, Contraception in women who cannot use estrogen-containing contraceptives.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}