{"id":"celecoxib-vitamin-b-fixed-dose","safety":{"commonSideEffects":[{"rate":"5-15%","effect":"Gastrointestinal upset"},{"rate":"5-10%","effect":"Headache"},{"rate":"2-5%","effect":"Dizziness"},{"rate":"2-5%","effect":"Hypertension"},{"rate":null,"effect":"Cardiovascular events (at higher doses/prolonged use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Celecoxib is a selective COX-2 inhibitor that reduces prostaglandin synthesis, thereby decreasing inflammation and pain without significantly affecting COX-1-mediated gastric protection. The fixed-dose combination with B vitamins (likely B1, B6, B12) aims to provide adjunctive neuroprotective and metabolic support, potentially reducing pain-related neurological symptoms and enhancing overall therapeutic benefit in inflammatory conditions.","oneSentence":"Celecoxib selectively inhibits cyclooxygenase-2 (COX-2) to reduce inflammation and pain, while B vitamins support metabolic and neurological function.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:44:09.774Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis"},{"name":"Rheumatoid arthritis"},{"name":"Acute pain conditions"},{"name":"Musculoskeletal pain with neuropathic component"}]},"trialDetails":[{"nctId":"NCT06516094","phase":"PHASE3","title":"Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain","status":"COMPLETED","sponsor":"Laboratorios Silanes S.A. de C.V.","startDate":"2024-04-11","conditions":"Chronic Low-back Pain","enrollment":192}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Cele+Vit B"],"phase":"phase_3","status":"active","brandName":"Celecoxib + Vitamin B fixed dose","genericName":"Celecoxib + Vitamin B fixed dose","companyName":"Laboratorios Silanes S.A. de C.V.","companyId":"laboratorios-silanes-s-a-de-c-v","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Celecoxib selectively inhibits cyclooxygenase-2 (COX-2) to reduce inflammation and pain, while B vitamins support metabolic and neurological function. Used for Osteoarthritis, Rheumatoid arthritis, Acute pain conditions.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}