{"id":"celecoxib-400-milligrams","safety":{"commonSideEffects":[{"rate":"15","effect":"Dyspepsia"},{"rate":"8","effect":"Abdominal pain"},{"rate":"5","effect":"Diarrhea"},{"rate":"12","effect":"Headache"},{"rate":"2","effect":"Hypertension"},{"rate":null,"effect":"Cardiovascular events (myocardial infarction, stroke)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a selective COX-2 inhibitor, celecoxib blocks the COX-2 enzyme preferentially over COX-1, which reduces inflammatory prostaglandins while theoretically sparing the protective prostaglandins produced by COX-1 in the gastrointestinal tract and kidneys. This selectivity was designed to provide anti-inflammatory and analgesic effects with a lower risk of gastrointestinal ulceration compared to non-selective NSAIDs.","oneSentence":"Celecoxib selectively inhibits cyclooxygenase-2 (COX-2), reducing the production of prostaglandins that mediate inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:23:51.920Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Osteoarthritis"},{"name":"Acute pain"},{"name":"Primary dysmenorrhea"},{"name":"Ankylosing spondylitis"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Celecoxib 400 milligrams","genericName":"Celecoxib 400 milligrams","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Celecoxib selectively inhibits cyclooxygenase-2 (COX-2), reducing the production of prostaglandins that mediate inflammation and pain. Used for Rheumatoid arthritis, Osteoarthritis, Acute pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}