{"id":"celecoxib-200-milligrams","safety":{"commonSideEffects":[{"rate":"15-20","effect":"Dyspepsia"},{"rate":"10-15","effect":"Abdominal pain"},{"rate":"5-10","effect":"Diarrhea"},{"rate":"10-15","effect":"Headache"},{"rate":"5-10","effect":"Hypertension"},{"rate":"1-2","effect":"Cardiovascular events (myocardial infarction, stroke)"}]},"_chembl":{"chemblId":"CHEMBL118","moleculeType":"Small molecule","molecularWeight":"381.38"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a selective COX-2 inhibitor, celecoxib preferentially blocks COX-2 while sparing COX-1, which is responsible for protective gastric and renal functions. This selectivity was designed to provide anti-inflammatory and analgesic effects with reduced gastrointestinal toxicity compared to non-selective NSAIDs. By decreasing prostaglandin E2 and other inflammatory mediators, it reduces pain, inflammation, and fever.","oneSentence":"Celecoxib selectively inhibits cyclooxygenase-2 (COX-2), reducing the production of prostaglandins that mediate inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:29:51.786Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Osteoarthritis"},{"name":"Acute pain"},{"name":"Primary dysmenorrhea"},{"name":"Ankylosing spondylitis"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Celecoxib 200 milligrams","genericName":"Celecoxib 200 milligrams","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Celecoxib selectively inhibits cyclooxygenase-2 (COX-2), reducing the production of prostaglandins that mediate inflammation and pain. Used for Rheumatoid arthritis, Osteoarthritis, Acute pain.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}