{"id":"ceftiofur","rwe":[{"pmid":"41902741","year":"2026","title":"Generation of equine-specific local antibiograms: reproductive tract of mares and fillies in Western Australia.","finding":"","journal":"Australian veterinary journal","studyType":"Clinical Study"},{"pmid":"41900379","year":"2026","title":"Epidemiology of Antimicrobial Residues and Phenotypic Resistance of Bacterial Isolates from Waste Milk on California Dairies.","finding":"","journal":"Microorganisms","studyType":"Clinical Study"},{"pmid":"41891173","year":"2026","title":"Research communication: Regional variation in antimicrobial resistance of Streptococcus agalactiae isolated from bovine mastitis in major dairy-producing provinces of northern China.","finding":"","journal":"The Journal of dairy research","studyType":"Clinical Study"},{"pmid":"41886440","year":"2026","title":"Bayesian network models to assess antimicrobial resistance patterns of Streptococcus suis isolated from swine production systems in the United States between 2014-2021.","finding":"","journal":"PLoS computational biology","studyType":"Clinical Study"},{"pmid":"41877220","year":"2026","title":"Distribution and characteristics of ceftiofur-resistant Escherichia coli throughout the broiler production chain in Korea.","finding":"","journal":"Veterinary research","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CEFTIOFUR","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:15:42.572693+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:15:48.980793+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CEFTIOFUR","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:15:49.535103+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Bacterial penicillin-binding protein inhibitor","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:15:50.580267+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL222913/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:15:50.235895+00:00"}},"allNames":"naxcel","offLabel":[],"synonyms":["ceftiofur","naxcel","ceftiofur sodium","ceftiofur hydrochloride","ceftiofur crystalline free acid"],"timeline":[],"aiSummary":"Naxcel (ceftiofur) is a small molecule antibiotic originally developed by Pfizer and currently owned by Zoetis. It is used to treat various bacterial infections in animals, including respiratory and skin infections. Naxcel is a cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis, ultimately leading to bacterial cell death. The commercial status of Naxcel is patented, and it is not yet off-patent. Key safety considerations include potential allergic reactions and interactions with other medications.","approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Naxcel","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"Naxcel (ceftiofur) is a third-generation cephalosporin antibiotic that exerts its antibacterial effects by inhibiting the enzyme transpeptidase, which is essential for bacterial cell wall synthesis. This inhibition leads to the accumulation of peptidoglycan precursors, ultimately causing cell lysis and bacterial death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5663","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CEFTIOFUR","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:29:03.791920","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:15:51.850091+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"ceftiofur","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"018137","UNII":"83JL932I1C","CHEBI":"CHEBI:31383","INN_ID":"5703","RXNORM":"1311520","UMLSCUI":"C0882426","chemblId":"CHEMBL222913","ChEMBL_ID":"CHEMBL222913","KEGG_DRUG":"D07657","DRUGBANK_ID":"DB11485","PUBCHEM_CID":"6328657","SNOMEDCT_US":"373556003","SECONDARY_CAS_RN":"104010-37-9","MESH_SUPPLEMENTAL_RECORD_UI":"C053503"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":1489,"therapeuticAreas":["Metabolic"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 28","pmid":"41902741","title":"Generation of equine-specific local antibiograms: reproductive tract of mares and fillies in Western Australia.","journal":"Australian veterinary journal"},{"date":"2026 Mar 10","pmid":"41900379","title":"Epidemiology of Antimicrobial Residues and Phenotypic Resistance of Bacterial Isolates from Waste Milk on California Dairies.","journal":"Microorganisms"},{"date":"2026 Mar 27","pmid":"41891173","title":"Research communication: Regional variation in antimicrobial resistance of Streptococcus agalactiae isolated from bovine mastitis in major dairy-producing provinces of northern China.","journal":"The Journal of dairy research"},{"date":"2026 Mar","pmid":"41886440","title":"Bayesian network models to assess antimicrobial resistance patterns of Streptococcus suis isolated from swine production systems in the United States between 2014-2021.","journal":"PLoS computational biology"},{"date":"2026 Mar 24","pmid":"41877220","title":"Distribution and characteristics of ceftiofur-resistant Escherichia coli throughout the broiler production chain in Korea.","journal":"Veterinary research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"BR","regulator":"ANVISA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MX","regulator":"COFEPRIS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AR","regulator":"ANMAT","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TR","regulator":"TITCK","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IN","regulator":"CDSCO","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TH","regulator":"FDA-TH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"MY","regulator":"NPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"PH","regulator":"FDA-PH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"CO","regulator":"INVIMA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"ZA","regulator":"SAHPRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"TW","regulator":"TFDA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"HK","regulator":"DH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:15:51.850091+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":false,"safety":false,"trials":false,"score":0}}