{"id":"ceftezole","rwe":[{"pmid":"40930792","year":"2025","title":"Cephalothin, a First-Generation Cephem Antibiotic, Works as a Potent Inducer of Parthanatos.","finding":"","journal":"Biological & pharmaceutical bulletin","studyType":"Clinical Study"},{"pmid":"35762600","year":"2022","title":"Haemophilus Influenzae-Induced Corneal Ulcer and Endophthalmitis Triggered by Hair Dye.","finding":"","journal":"The Journal of craniofacial surgery","studyType":"Clinical Study"},{"pmid":"34744720","year":"2021","title":"Status and Safety Signals of Cephalosporins in Children: A Spontaneous Reporting Database Study.","finding":"","journal":"Frontiers in pharmacology","studyType":"Clinical Study"},{"pmid":"33930689","year":"2021","title":"Behaviors and physical mechanism of ceftezole sodium de-agglomeration driven by ultrasound.","finding":"","journal":"Ultrasonics sonochemistry","studyType":"Clinical Study"},{"pmid":"32187097","year":"2020","title":"Does Surgical-site Multimodal Drug Injection After Palmar Plating of Distal Radius Fractures Improve Pain Scores?","finding":"","journal":"Clinical orthopaedics and related research","studyType":"Clinical Study"}],"tags":[{"label":"ceftezole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01DB12","category":"atc"},{"label":"Active","category":"status"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ceftezol","offLabel":[],"synonyms":["ceftezole","ceftezol","ceftezole sodium","demethylcefazolin","demethyl cefazolin"],"timeline":[],"brandName":"Ceftezol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"ceftezole","explanation":"Imagine the bacterial cell wall as a brick wall. Ceftezole blocks the enzymes that help build the wall, causing the wall to weaken and eventually collapse, killing the bacteria. This process is crucial for the bacteria to survive and multiply.","oneSentence":"Ceftezole works by inhibiting bacterial cell wall synthesis, ultimately leading to bacterial cell death.","technicalDetail":"Ceftezole exerts its antibacterial effect by inhibiting the transpeptidase enzymes responsible for cross-linking peptidoglycan chains in the bacterial cell wall, ultimately leading to cell lysis and death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/561","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CEFTEZOLE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T09:20:01.886037","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:55.492321+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"cefalexin","drugSlug":"cefalexin","fdaApproval":"1971-01-04","relationship":"same-class"},{"drugName":"cefalotin","drugSlug":"cefalotin","fdaApproval":"1974-12-18","relationship":"same-class"},{"drugName":"cefazolin","drugSlug":"cefazolin","fdaApproval":"1973-10-04","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cefadroxil","drugSlug":"cefadroxil","fdaApproval":"1978-02-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"cefapirin","drugSlug":"cefapirin","fdaApproval":"1974-03-12","relationship":"same-class"},{"drugName":"cefradine","drugSlug":"cefradine","fdaApproval":"1974-08-19","relationship":"same-class"}],"genericName":"ceftezole","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cefalexin","brandName":"cefalexin","genericName":"cefalexin","approvalYear":"1971","relationship":"same-class"},{"drugId":"cefalotin","brandName":"cefalotin","genericName":"cefalotin","approvalYear":"1974","relationship":"same-class"},{"drugId":"cefazolin","brandName":"cefazolin","genericName":"cefazolin","approvalYear":"1973","relationship":"same-class"},{"drugId":"cefadroxil","brandName":"cefadroxil","genericName":"cefadroxil","approvalYear":"1978","relationship":"same-class"},{"drugId":"cefapirin","brandName":"cefapirin","genericName":"cefapirin","approvalYear":"1974","relationship":"same-class"},{"drugId":"cefradine","brandName":"cefradine","genericName":"cefradine","approvalYear":"1974","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"010924","UNII":"2Z86SYP11W","CHEBI":"CHEBI:135716","INN_ID":"3914","UMLSCUI":"C0055013","ChEMBL_ID":"CHEMBL1697829","KEGG_DRUG":"D07656","DRUGBANK_ID":"DB13821","PUBCHEM_CID":"65755","IUPHAR_LIGAND_ID":"12259","SECONDARY_CAS_RN":"41136-22-5","MESH_SUPPLEMENTAL_RECORD_UI":"C012811"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"0.64 hours","clearance":"5.37 mL/min/kg"},"publicationCount":41,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01DB12","allCodes":["J01DB12"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"40930792","title":"Cephalothin, a First-Generation Cephem Antibiotic, Works as a Potent Inducer of Parthanatos.","journal":"Biological & pharmaceutical bulletin"},{"date":"2022 Sep 1","pmid":"35762600","title":"Haemophilus Influenzae-Induced Corneal Ulcer and Endophthalmitis Triggered by Hair Dye.","journal":"The Journal of craniofacial surgery"},{"date":"2021","pmid":"34744720","title":"Status and Safety Signals of Cephalosporins in Children: A Spontaneous Reporting Database Study.","journal":"Frontiers in pharmacology"},{"date":"2021 Jun","pmid":"33930689","title":"Behaviors and physical mechanism of ceftezole sodium de-agglomeration driven by ultrasound.","journal":"Ultrasonics sonochemistry"},{"date":"2020 Nov","pmid":"32187097","title":"Does Surgical-site Multimodal Drug Injection After Palmar Plating of Distal Radius Fractures Improve Pain Scores?","journal":"Clinical orthopaedics and related research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ceftezol is a small molecule antibiotic. It is also known by the synonyms CEFTEZOL, CEFTEZOLE, and J01DB12.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:55.492321+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}