{"id":"cefmetazole","rwe":[{"pmid":"41844876","year":"2026","title":"Analysis of perioperative antibiotic usage in the operating room during the 2019 cefazolin shortage in Japan: a multicenter observational study.","finding":"","journal":"Journal of anesthesia","studyType":"Clinical Study"},{"pmid":"41783331","year":"2026","title":"Aortic Arch Mural Thrombus Concurrent with Deep Surgical-Site Infection after Colorectal Cancer Surgery in an Enhanced Recovery after Surgery Program: A Case Report.","finding":"","journal":"Surgical case reports","studyType":"Clinical Study"},{"pmid":"41728536","year":"2026","title":"Obstructive Pyelonephritis With Enterococcal Bacteremia Despite Unremarkable Urinalysis.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"41672373","year":"2026","title":"Evaluation of an in-house rapid antimicrobial susceptibility testing (RAST) using the direct disk-diffusion method for gram-negative bacilli from positive blood cultures in a Japanese tertiary hospital.","finding":"","journal":"Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy","studyType":"Clinical Study"},{"pmid":"41586323","year":"2026","title":"Association between antimicrobial use and the detection rates of carbapenem-resistant Enterobacterales: long-term surveillance results from a single centre.","finding":"","journal":"Infection prevention in practice","studyType":"Clinical Study"}],"tags":[{"label":"cefmetazole","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Insulin-degrading enzyme","category":"target"},{"label":"IDE","category":"gene"},{"label":"J01DC09","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Haemophilus influenzae pneumonia","category":"indication"},{"label":"Infection of skin AND/OR subcutaneous tissue","category":"indication"},{"label":"Infectious disease of abdomen","category":"indication"},{"label":"Lower respiratory tract infection","category":"indication"},{"label":"Pneumonia","category":"indication"},{"label":"Pneumonia due to Escherichia coli","category":"indication"},{"label":"Approved 1980s","category":"decade"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"marketed","safety":{"safetySignals":[{"llr":59.79,"date":"","count":8,"signal":"Intrauterine infection","source":"DrugCentral FAERS","actionTaken":"Reported 8 times (LLR=60)"},{"llr":33.419,"date":"","count":16,"signal":"Hepatic function abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 16 times (LLR=33)"}],"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=CEFMETAZOLE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:11:11.510906+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:11:17.164159+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=CEFMETAZOLE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:11:17.773718+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201195/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:11:18.478551+00:00"}},"allNames":"zefazone","offLabel":[],"synonyms":["cefmetazole sodium","cefmetazole","cefmetazole sodium salt"],"timeline":[{"date":"1989-12-11","type":"positive","source":"DrugCentral","milestone":"FDA approval"},{"date":"1992-12-29","type":"positive","source":"FDA Orange Book","milestone":"Zefazone In Plastic Container approved — EQ 20MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**"}],"aiSummary":"Zefazone (CEFMETAZOLE) is a small molecule antibiotic developed by an unspecified original developer and currently owned by Pharmacia And Upjohn. 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